INT155684

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Context Info
Confidence 0.55
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 2.31
Pain Relevance 6.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc1a2) plasma membrane (Slc1a2)
Anatomy Link Frequency
cerebrum 4
Slc1a2 (Mus musculus)
Pain Link Frequency Relevance Heat
Physical dependence 8 99.16 Very High Very High Very High
tolerance 20 98.20 Very High Very High Very High
Glutamate 108 97.88 Very High Very High Very High
Morphine 30 97.88 Very High Very High Very High
analgesia 14 96.96 Very High Very High Very High
addiction 12 96.96 Very High Very High Very High
Opioid 6 95.08 Very High Very High Very High
cocaine 6 90.00 High High
cerebral cortex 4 89.56 High High
narcan 6 88.08 High High
Disease Link Frequency Relevance Heat
Epilepsy 4 99.22 Very High Very High Very High
Targeted Disruption 20 99.20 Very High Very High Very High
Drug Dependence 8 99.16 Very High Very High Very High
Pressure And Volume Under Development 10 67.44 Quite High
Convulsion 6 62.88 Quite High
Nociception 22 59.32 Quite High
Pathologic Processes 2 58.44 Quite High
Pain 52 58.00 Quite High
Anxiety Disorder 2 45.72 Quite Low
Injury 44 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increase in epileptic activity has also been seen when only GLT1 expression is lowered [34,35].
Negative_regulation (lowered) of Gene_expression (expression) of GLT1 associated with epilepsy
1) Confidence 0.55 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1609127 Disease Relevance 0.10 Pain Relevance 0.33
The suppression of down-regulation of cerebral GLT1 expression might mediate the attenuation of AQP4 deficiency to morphine tolerance and dependence.
Negative_regulation (down-regulation) of Gene_expression (expression) of GLT1 associated with addiction, tolerance and morphine
2) Confidence 0.38 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18973795 Disease Relevance 0.55 Pain Relevance 1.71
However, the down-regulation of GLT-1 expression diminished in AQP4 knockout mice.
Negative_regulation (down-regulation) of Gene_expression (expression) of GLT-1 associated with targeted disruption
3) Confidence 0.38 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18973795 Disease Relevance 0.59 Pain Relevance 1.98
Louis, Missouri, United States), actin (1:2,000; Roche, Basel, Switzerland), polyclonal: GLT1 (0.05 ?
Negative_regulation (polyclonal) of Gene_expression (Louis) of GLT1
4) Confidence 0.35 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1609127 Disease Relevance 0 Pain Relevance 0
A reduction in basal GLT1 expression in cerebrum was observed in AQP4 knock-out mice.
Negative_regulation (reduction) of Gene_expression (expression) of GLT1 in cerebrum associated with targeted disruption
5) Confidence 0.12 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923366 Disease Relevance 0.50 Pain Relevance 1.26
Compared with wild-type mice, the basal GLT1 expression in cerebrum was decreased by 23.1% and 26.5% in male and female AQP4 knock-out mice, respectively.
Negative_regulation (decreased) of Gene_expression (expression) of GLT1 in cerebrum associated with targeted disruption
6) Confidence 0.12 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923366 Disease Relevance 0.57 Pain Relevance 1.28

General Comments

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