INT155685

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Context Info
Confidence 0.50
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.77
Pain Relevance 2.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc1a3) plasma membrane (Slc1a3)
Anatomy Link Frequency
neuronal 2
Slc1a3 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 93 100.00 Very High Very High Very High
Morphine 12 99.58 Very High Very High Very High
Physical dependence 3 99.12 Very High Very High Very High
narcan 3 91.84 High High
analgesia 5 84.96 Quite High
long-term potentiation 2 83.68 Quite High
tolerance 7 83.52 Quite High
cerebral cortex 4 82.68 Quite High
Hippocampus 4 82.04 Quite High
Analgesic 1 80.64 Quite High
Disease Link Frequency Relevance Heat
Drug Dependence 3 99.12 Very High Very High Very High
Targeted Disruption 4 94.24 High High
Epilepsy 4 91.56 High High
Anxiety Disorder 2 84.68 Quite High
Generalized Anxiety Disorder 2 27.04 Quite Low
Sprains And Strains 2 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low
Body Weight 2 5.00 Very Low Very Low Very Low
Hypertrophy 2 5.00 Very Low Very Low Very Low
Peripheral Arterial Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
All the evidence supports the idea that regulating the expression of GLT1 and GLAST during a period of increased glutamate release, e.g., during increased sensory stimulation, is necessary for avoiding any effects of glutamate build-up.
Regulation (regulating) of Gene_expression (expression) of GLAST associated with glutamate
1) Confidence 0.50 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1609127 Disease Relevance 0.09 Pain Relevance 0.34
On a longer time scale, however, the expression levels of GLT1 and GLAST have been shown, in vitro, to depend on the level of neuronal activity [14].
Regulation (depend) of Gene_expression (expression) of GLAST in neuronal
2) Confidence 0.36 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1609127 Disease Relevance 0.08 Pain Relevance 0.36
This suggested that AQP4 deficiency inhibited the development of morphine physical dependence. (4) Repeated morphine administration down-regulated cerebral glutamate transporter 1 (GLT-1) expression in wild-type mice.
Regulation (regulated) of Gene_expression (expression) of glutamate transporter 1 associated with glutamate, physical dependence and morphine
3) Confidence 0.08 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18973795 Disease Relevance 0.60 Pain Relevance 2.15

General Comments

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