INT155689

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Context Info
Confidence 0.32
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 5.10
Pain Relevance 4.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ros1) cell proliferation (Ros1) plasma membrane (Ros1)
Anatomy Link Frequency
spinal cord 1
Ros1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 78 100.00 Very High Very High Very High
central sensitization 66 100.00 Very High Very High Very High
nMDA receptor 64 100.00 Very High Very High Very High
Pain 108 99.84 Very High Very High Very High
IPN 24 98.72 Very High Very High Very High
allodynia 78 98.62 Very High Very High Very High
Neuropathic pain 27 98.10 Very High Very High Very High
Inflammation 13 93.40 High High
Lasting pain 15 92.08 High High
Spinal nerve ligature 9 85.28 High High
Disease Link Frequency Relevance Heat
Pain 123 99.84 Very High Very High Very High
Inflammatory Pain 24 98.72 Very High Very High Very High
Neuropathic Pain 108 98.62 Very High Very High Very High
Injury 85 94.20 High High
INFLAMMATION 13 93.40 High High
Nervous System Injury 21 92.84 High High
Aids-related Complex 10 87.12 High High
Diabetes Mellitus 22 85.56 High High
Neointima 8 80.96 Quite High
Hyperplasia 5 80.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, in this study, we have performed two animal experiments to examine whether the increased ROS is involved in central sensitization through NMDA receptor phosphorylation in CPIP model.
Phosphorylation (phosphorylation) of ROS associated with pain, central sensitization and nmda receptor
1) Confidence 0.32 Published 2010 Journal The Korean Journal of Pain Section Body Doc Link PMC2884210 Disease Relevance 1.18 Pain Relevance 1.37
In this research, by means of a neuropathic pain model and an inflammatory pain model, the enhancement of N-methyl-D-aspartate (NMDA) receptor phosphorylation by ROS has drawn attention as an important mechanism of central sensitization [8-11].
Phosphorylation (phosphorylation) of ROS associated with central sensitization, ipn and neuropathic pain
2) Confidence 0.25 Published 2010 Journal The Korean Journal of Pain Section Body Doc Link PMC2884210 Disease Relevance 1.25 Pain Relevance 1.42
From this, it is suggested that the development of the allodynia mechanism, expressed in the CPIP model, may result in the increased ROS in spinal cord or peripheral tissue enhances NMDA receptor phosphorylation to induce central sensitization.
Phosphorylation (phosphorylation) of ROS in spinal cord associated with pain, central sensitization, allodynia, nmda receptor and spinal cord
3) Confidence 0.25 Published 2010 Journal The Korean Journal of Pain Section Body Doc Link PMC2884210 Disease Relevance 1.17 Pain Relevance 1.41
It has been hypothesized that quenching mechanisms during the phototransduction pathway are functionally affected in RCS rat, based upon the experimental evidence of several alterations in expressions of opsin (Nir et al 1987), and ROS protein phosphorylation levels (Heth and Schmidt 1992).
Phosphorylation (phosphorylation) of ROS protein
4) Confidence 0.15 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699806 Disease Relevance 0.24 Pain Relevance 0
Alagebrium dose-dependently inhibited AGE-mediated formation of reactive oxygen species (ROS), extracellular signal-regulated kinase phosphorylation, and cyclooxygenase-2 expression.
Phosphorylation (phosphorylation) of ROS
5) Confidence 0.14 Published 2010 Journal Korean Circulation Journal Section Abstract Doc Link PMC2978295 Disease Relevance 0.82 Pain Relevance 0.03
Lercanidipine also inhibited PDGF-receptor beta chain phosphorylation and reactive oxygen species (ROS) production induced by PDGF-BB.
Phosphorylation (phosphorylation) of ROS
6) Confidence 0.02 Published 2009 Journal Pharmacol. Res. Section Abstract Doc Link 18973813 Disease Relevance 0.44 Pain Relevance 0.13

General Comments

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