INT15569

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Context Info
Confidence 0.21
First Reported 1991
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.24
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PDE6C) plasma membrane (PDE6C)
Anatomy Link Frequency
colon 1
Arterioles 1
PDE6C (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 4 97.96 Very High Very High Very High
tetrodotoxin 1 86.88 High High
Angina 3 75.52 Quite High
ischemia 2 73.52 Quite High
adenocard 1 65.08 Quite High
headache 2 22.92 Low Low
backache 1 7.56 Low Low
Spinal cord 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 2 99.86 Very High Very High Very High
Coronary Heart Disease 1 98.40 Very High Very High Very High
Apoptosis 1 89.12 High High
Cancer 1 87.84 High High
Increased Venous Pressure Under Development 7 86.80 High High
Hypertension 9 86.16 High High
INFLAMMATION 1 76.20 Quite High
Cv General 3 Under Development 3 75.52 Quite High
Cv Unclassified Under Development 2 73.52 Quite High
Myocardial Infarction 3 61.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study indicates that concentrations of the NSAIDs celecoxib, indomethacin, and meclofenamic acid that inhibit growth of SW480 human colon cancer cells inhibit subcellular cGMP-phosphodiesterase (PDE) enzymatic activity and in intact cells induce a two- to threefold increase in intracellular levels of cGMP.
Negative_regulation (inhibit) of cGMP-phosphodiesterase in colon associated with colon cancer and cinod
1) Confidence 0.21 Published 2008 Journal Mol. Carcinog. Section Abstract Doc Link 18163459 Disease Relevance 0.43 Pain Relevance 0.25
Chronic inhibition of cGMP phosphodiesterase 5A by sildenafil prevents and reverses cardiac hypertrophy (Takimoto et al 2005).
Negative_regulation (inhibition) of cGMP phosphodiesterase associated with coronary heart disease
2) Confidence 0.11 Published 2006 Journal Clinical Interventions in Aging Section Body Doc Link PMC2699643 Disease Relevance 0.59 Pain Relevance 0.11
Arterioles were also dilated by 3-isobutyl-1-methylxanthine (IBMX), which is a non-selective inhibitor of cyclic AMP- and cyclic GMP-phosphodiesterase, and by rolipram, which is a selective inhibitor of the calcium-independent cyclic AMP-phosphodiesterase.
Negative_regulation (inhibitor) of GMP-phosphodiesterase in Arterioles
3) Confidence 0.02 Published 1991 Journal Exp. Physiol. Section Abstract Doc Link 1742017 Disease Relevance 0.22 Pain Relevance 0.12

General Comments

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