INT155694

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Context Info
Confidence 0.58
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.42
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (PDGFA) extracellular region (PDGFA) embryo development (PDGFA)
cell-cell signaling (PDGFA)
Anatomy Link Frequency
fibroblasts 1
PDGFA (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 1 69.20 Quite High
antagonist 1 65.76 Quite High
Calcium channel 1 65.32 Quite High
fibrosis 27 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 2 76.80 Quite High
Cv General 3 Under Development 1 69.20 Quite High
Neointima 2 68.64 Quite High
Hypertension 1 68.40 Quite High
Fibrosis 25 5.00 Very Low Very Low Very Low
Pulmonary Fibrosis 9 5.00 Very Low Very Low Very Low
Cancer 6 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low
Hyperplasia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To investigate the impact of radiation to PDGFR in fibroblasts and the effect of SU9518 on phosphorylation of PDGF RTK in fibroblasts after radiation, human dermal fibroblast cells were pre-treated with 5 ?
Phosphorylation (phosphorylation) of PDGF RTK in fibroblasts
1) Confidence 0.58 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1458351 Disease Relevance 0 Pain Relevance 0
FBS- and PDGF-BB-stimulated intracellular Ras, MEK1/2, ERK1/2, proliferative cell nuclear antigen (PCNA), and Akt activations were significantly inhibited by lercanidipine; however, lercanidipine did not affect FBS- and PDGF-BB-induced STAT3 phosphorylation.
Phosphorylation (phosphorylation) of PDGF-BB
2) Confidence 0.04 Published 2009 Journal Pharmacol. Res. Section Abstract Doc Link 18973813 Disease Relevance 0.42 Pain Relevance 0.13

General Comments

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