INT155699

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Context Info
Confidence 0.81
First Reported 2008
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.49
Pain Relevance 1.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Bdnf) cytoplasmic membrane-bounded vesicle (Bdnf)
Anatomy Link Frequency
brain 1
Bdnf (Mus musculus)
Pain Link Frequency Relevance Heat
fluoxetine 27 93.44 High High
neurotrophin 3 9 93.44 High High
Kinase C 11 89.12 High High
Eae 5 84.00 Quite High
antidepressant 64 80.16 Quite High
depression 83 79.40 Quite High
Inflammation 13 72.92 Quite High
Hippocampus 49 58.80 Quite High
qutenza 1 53.52 Quite High
GABAergic 29 50.00 Quite Low
Disease Link Frequency Relevance Heat
Repression 2 91.92 High High
Depression 105 85.16 High High
Body Weight 3 84.72 Quite High
Suicidal Behaviour 123 76.64 Quite High
INFLAMMATION 17 72.92 Quite High
Anxiety Disorder 7 67.24 Quite High
Stress 27 65.20 Quite High
Injury 4 54.60 Quite High
Cognitive Disorder 6 52.60 Quite High
Cytomegalovirus Infection 56 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Membrane depolarization triggers the calcium-dependent phosphorylation and release of MeCP2 from BDNF promoter III, thereby facilitating transcription.177 On the other hand, membrane depolarization causes increased BDNF transcription, which involves dissociation of the MeCP2-histone deacetylase-mSin3A repression complex from its promoter,177,178 which suggests that DNA methylation-related chromatin remodeling is important for activity-dependent Bdnf gene regulation.
Phosphorylation (phosphorylation) of BDNF associated with repression
1) Confidence 0.81 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.84 Pain Relevance 0.18
However, chromatin immunoprecipitation studies did not reveal any changes in the acetylation or trimethylation of histone H3 at the BDNF promoters.
Phosphorylation (acetylation) of BDNF
2) Confidence 0.71 Published 2009 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 18973993 Disease Relevance 0.40 Pain Relevance 0.86
for BDNF; sense 5?
Phosphorylation (for) of BDNF
3) Confidence 0.49 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020957 Disease Relevance 0 Pain Relevance 0.08
Similarly, brain-derived neurotrophic factor (BDNF) produces short-term and long-term effects via modulation of the phosphorylation state of GABAA receptors.
Phosphorylation (phosphorylation) of BDNF in brain
4) Confidence 0.42 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2526003 Disease Relevance 0.11 Pain Relevance 0.13
BMSC demonstrate Akt phosphorylation following NGF or BDNF exposure
Phosphorylation (phosphorylation) of BDNF
5) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2837737 Disease Relevance 0.14 Pain Relevance 0.12

General Comments

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