INT155702

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Context Info
Confidence 0.48
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0.20

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pigmentation (MC1R) extracellular region (CAMP) plasma membrane (MC1R)
signal transducer activity (MC1R)
Anatomy Link Frequency
pigmentation 2
MC1R (Homo sapiens)
CAMP (Homo sapiens)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 2 100.00 Very High Very High Very High
antagonist 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Microphthalmia 2 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To date, the principal receptor considered to regulate human pigmentation is the melanocortin-1 receptor (MC1-R) via induction of the cAMP/protein kinase A pathway by the melanocortins alpha-MSH and ACTH.
melanocortin-1 receptor Positive_regulation (induction) of cAMP in pigmentation associated with melanocortin 1 receptor
1) Confidence 0.48 Published 2009 Journal Endocrinology Section Abstract Doc Link 18974267 Disease Relevance 0 Pain Relevance 0.10
To date, the principal receptor considered to regulate human pigmentation is the melanocortin-1 receptor (MC1-R) via induction of the cAMP/protein kinase A pathway by the melanocortins alpha-MSH and ACTH.
MC1-R Positive_regulation (induction) of cAMP in pigmentation associated with melanocortin 1 receptor
2) Confidence 0.48 Published 2009 Journal Endocrinology Section Abstract Doc Link 18974267 Disease Relevance 0 Pain Relevance 0.10

General Comments

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