INT155704

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Context Info
Confidence 0.45
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 7.51
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (MITF) protein complex assembly (MITF) DNA binding (MITF)
protein complex (MITF)
Anatomy Link Frequency
brain 3
blood 1
epithelial cell 1
melanocytes 1
MITF (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 19 99.84 Very High Very High Very High
rheumatoid arthritis 56 97.64 Very High Very High Very High
Central nervous system 7 97.38 Very High Very High Very High
antagonist 1 94.60 High High
Chronic pancreatitis 14 84.96 Quite High
melanocortin 1 receptor 1 57.72 Quite High
alcohol 2 42.48 Quite Low
Potency 1 35.56 Quite Low
Inflammation 15 5.00 Very Low Very Low Very Low
Spinal cord 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Microphthalmia 1 100.00 Very High Very High Very High
Pancreatic Cancer 98 99.84 Very High Very High Very High
Lymphatic System Cancer 7 99.84 Very High Very High Very High
Cancer 1186 99.02 Very High Very High Very High
Glioblastoma 35 97.72 Very High Very High Very High
Rheumatoid Arthritis 56 97.64 Very High Very High Very High
Apoptosis 59 91.80 High High
Pancreatitis 14 84.96 Quite High
Prostate Cancer 140 84.52 Quite High
Colon Cancer 28 74.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Importantly, increased melanogenesis after stimulation of the beta-MSH/cAMP/microphthalmia-associated transcription factor/tyrosinase cascade proved the functionality of this signal in melanocytes, which was attenuated in the presence of the specific MC4-R antagonist HS014.
Positive_regulation (stimulation) of microphthalmia-associated transcription factor in melanocytes associated with antagonist and microphthalmia
1) Confidence 0.45 Published 2009 Journal Endocrinology Section Abstract Doc Link 18974267 Disease Relevance 0.10 Pain Relevance 0.11
In vitro studies in a human epithelial cell line (Jepsen et al. 2004) comparing the cytokine stimulation potencies of monophthalates showed MEHP, MnOP, and MiNP to be more potent inducers of cytokines than MnBP or MBnP (Jepsen et al. 2004); in contrast to the in vivo work, MiDP was a potent inducer of cytokines.
Positive_regulation (inducer) of MiDP in epithelial cell associated with cytokine
2) Confidence 0.01 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2453150 Disease Relevance 0 Pain Relevance 0.15
A number of cancer types have been identified where a significant number of miRNAs are either upregulated or downregulated (see Table 1).
Positive_regulation (upregulated) of miRNAs associated with cancer
3) Confidence 0.01 Published 2010 Journal Silenc Section Body Doc Link PMC2835996 Disease Relevance 1.30 Pain Relevance 0
For example, in brain (central nervous system and glioblastoma) 94% of the miRNAs (79/84) are downregulated (P = 7.106 × 10-16, Fisher's exact test), and in hematogic, all the miRNAs (32/32) are downregulated (P = 1.642 × 10-8, Fisher's exact test); on the other hand 91.3% of the miRNAs (42/46) are upregulated in pancreatic cancer (P = 6.639 × 10-13, Fisher's exact test) and all the miRNAs (9/9) are upregulated in lymphoma (P = 4.228 × 10-4, Fisher's exact test).
Positive_regulation (upregulated) of miRNAs in brain associated with lymphatic system cancer, glioblastoma, pancreatic cancer and central nervous system
4) Confidence 0.01 Published 2010 Journal Silenc Section Body Doc Link PMC2835996 Disease Relevance 0.97 Pain Relevance 0.05
In our present study we found that, 46 miRNAs are dysregulated in pancreatic cancer among which a significant number of miRNAs are overexpressed (P = 6.639 × 10-13, for details see Table 1) showing that miRNAs tend to be upregulated in pancreatic tumor tissue.
Positive_regulation (upregulated) of miRNAs associated with pancreatic cancer
5) Confidence 0.01 Published 2010 Journal Silenc Section Body Doc Link PMC2835996 Disease Relevance 1.61 Pain Relevance 0.08
For example, in brain (central nervous system and glioblastoma) 94% of the miRNAs (79/84) are downregulated (P = 7.106 × 10-16, Fisher's exact test), and in hematogic, all the miRNAs (32/32) are downregulated (P = 1.642 × 10-8, Fisher's exact test); on the other hand 91.3% of the miRNAs (42/46) are upregulated in pancreatic cancer (P = 6.639 × 10-13, Fisher's exact test) and all the miRNAs (9/9) are upregulated in lymphoma (P = 4.228 × 10-4, Fisher's exact test).
Positive_regulation (upregulated) of miRNAs in brain associated with lymphatic system cancer, glioblastoma, pancreatic cancer and central nervous system
6) Confidence 0.01 Published 2010 Journal Silenc Section Body Doc Link PMC2835996 Disease Relevance 0.89 Pain Relevance 0.05
For example, in brain (central nervous system and glioblastoma) 94% of the miRNAs (79/84) are downregulated (P = 7.106 × 10-16, Fisher's exact test), and in hematogic, all the miRNAs (32/32) are downregulated (P = 1.642 × 10-8, Fisher's exact test); on the other hand 91.3% of the miRNAs (42/46) are upregulated in pancreatic cancer (P = 6.639 × 10-13, Fisher's exact test) and all the miRNAs (9/9) are upregulated in lymphoma (P = 4.228 × 10-4, Fisher's exact test).
Positive_regulation (upregulated) of miRNAs in brain associated with lymphatic system cancer, glioblastoma, pancreatic cancer and central nervous system
7) Confidence 0.01 Published 2010 Journal Silenc Section Body Doc Link PMC2835996 Disease Relevance 0.88 Pain Relevance 0.05
In this network model several cancer types have been identified where almost all the miRNAs are either upregulated or downregulated.
Positive_regulation (upregulated) of miRNAs associated with cancer
8) Confidence 0.01 Published 2010 Journal Silenc Section Body Doc Link PMC2835996 Disease Relevance 0.92 Pain Relevance 0
From the network, a number of upregulated and downregulated miRNAs obtained from the specific cancer tissue type are considered as the experimental data set.
Positive_regulation (upregulated) of miRNAs associated with cancer
9) Confidence 0.01 Published 2010 Journal Silenc Section Body Doc Link PMC2835996 Disease Relevance 0.42 Pain Relevance 0
Compared with normal peripheral blood CD4+ T cells, pairwise significance analysis of microarray data indicated that the expression levels of eight miRNAs (miR-363, miR-512-5P, miR-345-MM, miR-146a, miR-146b, miR-296, miR-133b and miR-150) were increased more than two-fold by a change in CD4+ T cells of SF from RA patients whereas eight miRNAs (miR-331, miR-29a, miR-26a, miR-498, miR-129, let-7a, let-7d and miR-21) were significantly downregulated (Figure 1a).
Positive_regulation (increased) of miRNAs in blood associated with rheumatoid arthritis
10) Confidence 0.00 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911863 Disease Relevance 0.44 Pain Relevance 0.22

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