INT155724

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Context Info
Confidence 0.53
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.35
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Bcl2) aging (Bcl2) cell morphogenesis (Bcl2)
endoplasmic reticulum (Bcl2) intracellular (Bcl2) response to stress (Bcl2)
Bcl2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 58 99.36 Very High Very High Very High
Central nervous system 2 79.24 Quite High
Morphine 6 50.00 Quite Low
anesthesia 4 32.88 Quite Low
cytokine 7 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Opioid 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Retina Disease 17 99.36 Very High Very High Very High
Cv Unclassified Under Development 37 98.56 Very High Very High Very High
Leukemia 16 97.08 Very High Very High Very High
Ocular Hypertension 8 97.08 Very High Very High Very High
Apoptosis 90 85.56 High High
Necrosis 14 84.48 Quite High
Ganglion Cysts 3 83.28 Quite High
Injury 23 81.60 Quite High
Solid Tumor 12 80.56 Quite High
Cv General 4 Under Development 4 78.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In another report, retinal ischemia was shown to induce an initial decrease in Bcl-2 mRNA expression followed by a later increase in its expression [21].
Negative_regulation (decrease) of Transcription (expression) of Bcl-2 associated with ischemia and retina disease
1) Confidence 0.53 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0.83 Pain Relevance 0.29
Oblimersen (Genasense®, Bcl-2 antisense, G3139) is a synthetic, 18-base, single-stranded phosphorothioate DNA oligonucleotide designed to downregulate bcl-2 mRNA expression (Klasa et al 2002).
Negative_regulation (downregulate) of Transcription (expression) of bcl-2
2) Confidence 0.47 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376092 Disease Relevance 0.46 Pain Relevance 0
Ischemia for 1 h followed by 3 h reperfusion resulted in significant (P < 0.05) decreases in mRNA and protein expression of Bcl-2 when compared with L-arginine-treated rats [Figures 2 and 3].


Negative_regulation (decreases) of Transcription (expression) of Bcl-2 associated with ischemia
3) Confidence 0.41 Published 2009 Journal Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association Section Body Doc Link PMC2841413 Disease Relevance 0.65 Pain Relevance 0.08
Patients who achieved a complete response showed decreases in median bcl-2 mRNA and protein levels relative to baseline.
Negative_regulation (decreases) of Transcription (levels) of bcl-2
4) Confidence 0.35 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376092 Disease Relevance 0.34 Pain Relevance 0
In the present study, 72-hour preincubation of PC12 cells with 1.2 mM lithium chloride reversed the effects of morphine on the mRNA expression of BAX and BCL-2.
Negative_regulation (reversed) of Transcription (expression) of BCL-2
5) Confidence 0.16 Published 2008 Journal Arch Iran Med Section Body Doc Link 18976035 Disease Relevance 0 Pain Relevance 0
Quantitative real-time RT-polymerase chain reaction revealed that mRNA expression of BAX (proapoptotic element) increased while a decrement in the mRNA expression of BCL-2 (protective element) was observed after six hours (but not after 12 or 24 hours) exposure to morphine.
Negative_regulation (decrement) of Transcription (expression) of BCL-2
6) Confidence 0.16 Published 2008 Journal Arch Iran Med Section Body Doc Link 18976035 Disease Relevance 0.08 Pain Relevance 0

General Comments

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