INT155775

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Context Info
Confidence 0.65
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 10.18
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
osteoclast 1
PDB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 16 94.60 High High
cytokine 24 79.80 Quite High
Nerve growth factor 33 76.32 Quite High
Inflammation 9 73.68 Quite High
Pain 16 69.40 Quite High
addiction 9 39.48 Quite Low
Osteoarthritis 2 21.20 Low Low
Arthritis 2 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bone Disease 514 100.00 Very High Very High Very High
Syndrome 74 100.00 Very High Very High Very High
Disease 238 99.66 Very High Very High Very High
Frontotemporal Dementia 16 98.88 Very High Very High Very High
Hypercalcemia 35 98.68 Very High Very High Very High
Muscle Disease 16 96.96 Very High Very High Very High
Infection 19 96.40 Very High Very High Very High
Viral Meningitis 9 96.12 Very High Very High Very High
Osteoporosis 35 96.08 Very High Very High Very High
Rheumatoid Arthritis 17 94.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
high resolution X-ray structure of ferredoxin (PDB code: 1awd)) and molecular dynamics simulations in aqueous medium using AMBER 6 of the NS4 region of Japanese encephalitis virus (JEV) suggests it is closely related to the iron-binding
Gene_expression (code) of PDB associated with viral meningitis
1) Confidence 0.65 Published 2008 Journal Bioinformation Section Body Doc Link PMC2586131 Disease Relevance 0.39 Pain Relevance 0
A potential explanation for these findings is the existence of genetic heterogeneity, with possible modifier loci capable of controlling the clinical expression of PDB [4,9].
Gene_expression (expression) of PDB associated with bone disease
2) Confidence 0.57 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297578 Disease Relevance 1.25 Pain Relevance 0
Importantly, mutations of SQSTM1 are highly specific for PDB and have not been found in unaffected age matched controls derived from the general population in any of the studies that have been performed so far [9,14-17].
Gene_expression (specific) of PDB associated with bone disease
3) Confidence 0.44 Published 2008 Journal BMC Health Serv Res Section Body Doc Link PMC2442429 Disease Relevance 1.16 Pain Relevance 0
A single intravenous administration of ZOL leads to a favorable clinical, biochemical, and scintigraphic response in patients with PDB starting as early as 3 months after treatment and lasting no less than 12 months (i.e., considerably longer than the other existing therapies).
Gene_expression (starting) of PDB associated with bone disease
4) Confidence 0.22 Published 2008 Journal J. Bone Miner. Metab. Section Abstract Doc Link 18979164 Disease Relevance 0.62 Pain Relevance 0.07
RAW264.7 or monocytes) carrying PDB mutant p62 into OLCs [21,22] represent potential assay systems for developing high-throughput screens for the identification of lead compounds which may be useful in correcting disordered osteoclast NF-?
Gene_expression (carrying) of PDB in osteoclast associated with bone disease
5) Confidence 0.07 Published 2007 Journal BMC Biochem Section Body Doc Link PMC2106369 Disease Relevance 0.58 Pain Relevance 0
Finally, two separate groups have shown that under certain conditions, ectopic expression of PDB mutant p62 evokes more efficient activation of NF-?
Gene_expression (mutant) of PDB associated with bone disease
6) Confidence 0.06 Published 2007 Journal BMC Biochem Section Body Doc Link PMC2106369 Disease Relevance 0.68 Pain Relevance 0
Molecular defects in PDB and related syndromes
Gene_expression (defects) of PDB associated with syndrome and bone disease
7) Confidence 0.06 Published 2007 Journal BMC Biochem Section Body Doc Link PMC2106369 Disease Relevance 2.13 Pain Relevance 0.07
However, a more recent study also using reporter assays noted that although PDB mutant p62 constructs activated NF-?
Gene_expression (constructs) of PDB associated with bone disease
8) Confidence 0.06 Published 2007 Journal BMC Biochem Section Body Doc Link PMC2106369 Disease Relevance 0.48 Pain Relevance 0.07
Disease mechanism(s) in PDB and related syndromes
Gene_expression (syndromes) of PDB associated with syndrome, disease and bone disease
9) Confidence 0.06 Published 2007 Journal BMC Biochem Section Body Doc Link PMC2106369 Disease Relevance 0.70 Pain Relevance 0
B activation is thought to involve OPG-RANK and p62 (Figure 1), each of which are (separately) mutated in PDB and related syndromes, indicating that altered function of this particular signalling cascade is likely to be important in PDB aetiology.
Gene_expression (aetiology) of PDB associated with syndrome and bone disease
10) Confidence 0.06 Published 2007 Journal BMC Biochem Section Body Doc Link PMC2106369 Disease Relevance 0.45 Pain Relevance 0.04
Finally, two separate groups have shown that under certain conditions, ectopic expression of PDB mutant p62 evokes more efficient activation of NF-?
Gene_expression (expression) of PDB associated with bone disease
11) Confidence 0.06 Published 2007 Journal BMC Biochem Section Body Doc Link PMC2106369 Disease Relevance 0.78 Pain Relevance 0
B signalling axis, and its control by ubiquitylation, may represent a viable therapeutic strategy for the treatment of PDB syndromes as well as other diseases where excessive bone resorption or remodelling is a feature, including osteoporosis, peridontal disease and rheumatoid arthritis.
Gene_expression (syndromes) of PDB associated with syndrome, rheumatoid arthritis, osteoporosis, hypercalcemia, disease and bone disease
12) Confidence 0.06 Published 2007 Journal BMC Biochem Section Body Doc Link PMC2106369 Disease Relevance 0.98 Pain Relevance 0.16

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