INT15578

Context Info Confidence 0.07 First Reported 1991 Last Reported 1999 Negated 1 Speculated 0 Reported most in Abstract Documents 3 Total Number 3 Disease Relevance 0 Pain Relevance 1.22

signal transduction (GNRH1) extracellular space (GNRH1) extracellular region (GNRH1) cell-cell signaling (GNRH1)

Anatomy Link Frequency pituitary gland 2 GNRH1 (Homo sapiens) Lhb (Mus musculus)

Pain Link Frequency Relevance Heat Serotonin 8 100.00 narcan 20 98.76 opiate 2 98.24 Endogenous opioid 2 98.14 antagonist 3 97.96 halothane 2 94.52 ketamine 2 87.76 Opioid 6 25.00 anesthesia 1 25.00

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We have systematically investigated the involvement of endogenous opioids in gonadotropin secretion during primate sexual maturation by examining LH/FSH responses to gonadotropin-releasing hormone (GnRH) and changes in LH secretion during infusions of saline or naloxone, an opiate antagonist, in ten male chimpanzees between one and nine years of age.

gonadotropin-releasing hormone Regulation (changes) of Localization (secretion) of LH associated with antagonist, narcan, endogenous opioid and opiate

1) Confidence 0.07 Published 1991 Journal Brain Res. Bull. Section Abstract Doc Link 1742612 Disease Relevance 0 Pain Relevance 0.45

We have systematically investigated the involvement of endogenous opioids in gonadotropin secretion during primate sexual maturation by examining LH/FSH responses to gonadotropin-releasing hormone (GnRH) and changes in LH secretion during infusions of saline or naloxone, an opiate antagonist, in ten male chimpanzees between one and nine years of age.

GnRH Regulation (changes) of Localization (secretion) of LH associated with antagonist, narcan, endogenous opioid and opiate

2) Confidence 0.07 Published 1991 Journal Brain Res. Bull. Section Abstract Doc Link 1742612 Disease Relevance 0 Pain Relevance 0.45

In comparison with the vehicle-treated controls, the response of plasma LH to exogenous GnRH was not altered by serotonin or cyproheptadine in either season, which shows that serotonin has no effect on LH release at the pituitary gland level in these animals.

GnRH Neg (no) Regulation (effect) of Localization (release) of LH in pituitary gland associated with serotonin

3) Confidence 0.05 Published 1999 Journal Reprod. Fertil. Dev. Section Abstract Doc Link 10735553 Disease Relevance 0 Pain Relevance 0.33

General Comments

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