INT155780

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Context Info
Confidence 0.77
First Reported 2001
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 19
Total Number 24
Disease Relevance 15.85
Pain Relevance 6.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp8) extracellular space (Mmp8) extracellular region (Mmp8)
proteinaceous extracellular matrix (Mmp8)
Anatomy Link Frequency
lung 6
neutrophil 3
fibroblasts 2
joint 2
synovial fluid 1
Mmp8 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 812 100.00 Very High Very High Very High
Inflammatory response 78 98.72 Very High Very High Very High
rheumatoid arthritis 136 98.40 Very High Very High Very High
Arthritis 27 98.20 Very High Very High Very High
Inflammation 427 97.32 Very High Very High Very High
fibrosis 322 96.40 Very High Very High Very High
cytokine 205 92.88 High High
Mechanotransduction 14 91.56 High High
Inflammatory stimuli 4 88.12 High High
alcohol 4 81.76 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 122 99.84 Very High Very High Very High
Bronchiolitis Obliterans 4 99.84 Very High Very High Very High
Fibrosis 222 99.64 Very High Very High Very High
Lung Injury 442 98.76 Very High Very High Very High
Rheumatoid Arthritis 136 98.40 Very High Very High Very High
INFLAMMATION 498 98.36 Very High Very High Very High
Pulmonary Disease 20 98.24 Very High Very High Very High
Arthritis 36 98.20 Very High Very High Very High
Infection 91 97.52 Very High Very High Very High
Hyperoxia 7 97.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemical studies demonstrated IL-10 expression in epithelial cells and fibroblasts, whereas MMP-8 was expressed in fibroblasts (Figure 5C).
Gene_expression (expressed) of MMP-8 in fibroblasts
1) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2951918 Disease Relevance 0.45 Pain Relevance 0.33
As expected, MMP-8 was not detected in knockout mice.
Neg (not) Gene_expression (detected) of MMP-8 associated with targeted disruption
2) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2951918 Disease Relevance 0.67 Pain Relevance 0.15
MMP-8 processes IL-10 in vitro and in vivo
Gene_expression (processes) of MMP-8
3) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2951918 Disease Relevance 0.41 Pain Relevance 0.25
MMP8 expression was also increased following ventilation but it was restricted to certain cell types, presumably mononuclear cells, and localized primarily in the cell membrane (Figure 9, A and B).
Gene_expression (expression) of MMP8 in mononuclear cells
4) Confidence 0.66 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2223071 Disease Relevance 0.20 Pain Relevance 0.03
Our results suggest that strategies to modulate MAPK and/or MMP8 activation may have potential therapeutic benefit in patients suffering from ventilator-associated lung injury/ARDS.


Gene_expression (activation) of MMP8 in lung associated with lung injury and adult respiratory distress syndrome
5) Confidence 0.66 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2223071 Disease Relevance 0.95 Pain Relevance 0.09
We observed the expression of 3 forms of MMP8: pro-MMP8, active MMP8 and an inactive degradation product of MMP8 (85, 65 and 30 kDa molecular weight respectively) in lung tissue.
Gene_expression (expression) of MMP8 in lung
6) Confidence 0.59 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2223071 Disease Relevance 0.14 Pain Relevance 0.04
The effect of increased MMP8 expression in our model is detailed in Figure 12.
Gene_expression (expression) of MMP8
7) Confidence 0.59 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2223071 Disease Relevance 0.99 Pain Relevance 0.04
In the absence of MMP8, increased MMP9 production was detected.
Neg (absence) Gene_expression (absence) of MMP8
8) Confidence 0.59 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2223071 Disease Relevance 0.99 Pain Relevance 0.07
MMP8 protein expression analysis was previously described by Tester et al.[20].
Gene_expression (expression) of MMP8
9) Confidence 0.59 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2223071 Disease Relevance 0.13 Pain Relevance 0.03
The decreased collagen levels in mice lacking a collagenase suggested that the benefits seen in these animals were not related to the effects of MMP-8 on the extracellular matrix proteins.
Gene_expression (effects) of MMP-8 in extracellular matrix
10) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2951918 Disease Relevance 0.60 Pain Relevance 0.30
MMP-8 (Figure 3G) was expressed mainly in fibroblasts, whereas MMP-9 expression was restricted to inflammatory cells, mainly neutrophils, as shown by immunohistochemistry (Figure 3H).


Gene_expression (expressed) of MMP-8 in fibroblasts associated with inflammation
11) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2951918 Disease Relevance 1.01 Pain Relevance 0.24
The levels of MMP-8 in lung tissue were measured by western blotting.
Gene_expression (levels) of MMP-8 in lung
12) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2951918 Disease Relevance 0.22 Pain Relevance 0.11
We observed the expression of 3 forms of MMP8: pro-MMP8, active MMP8 and an inactive degradation product of MMP8 (85, 65 and 30 kDa molecular weight respectively) in lung tissue.
Gene_expression (expression) of MMP8 in lung
13) Confidence 0.52 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2223071 Disease Relevance 0.14 Pain Relevance 0.04
In fibrotic animals, hepatic expression of MMP-2, MMP-3, MMP-8, MMP-9 and MMP-13 mRNA were all significantly upregulated, compared to non-fibrotic controls (Figure 6).
Gene_expression (expression) of MMP-8 associated with fibrosis
14) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892485 Disease Relevance 0.33 Pain Relevance 0.06
The assessment of MMP8 protein expression—a marker of neutrophil infiltration—was increased in whole livers of rats injected intravenously with mitochondrial DAMPs whereas control rats showed no evidence of hepatic inflammation.
Gene_expression (expression) of MMP8 in livers associated with cirrhosis and inflammation
15) Confidence 0.24 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2939438 Disease Relevance 0.95 Pain Relevance 0.34
MMP-8 (neutrophil Collagenase) and MMP-9 (Gelatinase 2) are synthesized and stored in PMN [6].
Gene_expression (synthesized) of neutrophil Collagenase in neutrophil associated with metalloproteinase
16) Confidence 0.19 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2518539 Disease Relevance 0.82 Pain Relevance 0.52
MMP-8 (neutrophil Collagenase) and MMP-9 (Gelatinase 2) are synthesized and stored in PMN [6].
Gene_expression (synthesized) of MMP-8 in neutrophil associated with metalloproteinase
17) Confidence 0.19 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2518539 Disease Relevance 0.82 Pain Relevance 0.52
Taghavi and coworkers have described increased MMP-9 and MMP-8 levels in bronchiolitis obliterans from lung transplant patients [28].
Gene_expression (levels) of MMP-8 in lung associated with bronchiolitis obliterans and metalloproteinase
18) Confidence 0.19 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2518539 Disease Relevance 1.39 Pain Relevance 0.94
Segura-Valdez et al. have found increased levels of MMP-8 and MMP-9 in Mini-BAL and lung biopsies of COPD patients [25].
Gene_expression (levels) of MMP-8 in lung associated with pulmonary disease and metalloproteinase
19) Confidence 0.17 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2518539 Disease Relevance 1.21 Pain Relevance 0.96
It is possible that in the rheumatoid joint, where expression of MMP-8 and MMP-9 is increased [24], sRAGE levels are regulated by matrix metalloproteinases in a similar manner.
Gene_expression (expression) of MMP-8 in joint associated with metalloproteinase
20) Confidence 0.13 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175032 Disease Relevance 0.77 Pain Relevance 0.36

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