INT1558

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Context Info
Confidence 0.69
First Reported 1979
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 30
Total Number 32
Disease Relevance 5.78
Pain Relevance 22.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

ATPase activity (Dnahc8) cytoskeleton (Dnahc8) cilium (Dnahc8)
molecular_function (Dnahc8) biological_process (Dnahc8) cytoplasm (Dnahc8)
Anatomy Link Frequency
brain 2
spinal 1
Dnahc8 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 11 100.00 Very High Very High Very High
adenocard 9 100.00 Very High Very High Very High
Analgesic 6 100.00 Very High Very High Very High
Oxycodone 9 99.98 Very High Very High Very High
methadone 7 99.98 Very High Very High Very High
Morphine 128 99.92 Very High Very High Very High
opioid receptor 24 99.84 Very High Very High Very High
Cannabinoid 20 99.82 Very High Very High Very High
narcan 36 99.76 Very High Very High Very High
Dopamine 4 99.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 58 99.46 Very High Very High Very High
Shock 10 98.72 Very High Very High Very High
Hypoalagesia 4 98.52 Very High Very High Very High
Muscular Dystrophy 6 97.92 Very High Very High Very High
Targeted Disruption 19 97.64 Very High Very High Very High
Bordatella Infection 10 96.20 Very High Very High Very High
Paralysis 3 94.88 High High
Opiate Addiction 6 92.96 High High
Congenital Anomalies 10 90.20 High High
Neuropathic Pain 3 87.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Naloxone, an opioid antagonist (10(-6) M), added to the synaptosomal medium, antagonized the enhancement of Na(+),K(+)-ATPase activity induced by morphine, producing a parallel shift to the right of the morphine concentration-response curve.
Positive_regulation (induced) of ATPase associated with antagonist, narcan, opioid and morphine
1) Confidence 0.69 Published 2002 Journal Brain Res. Section Abstract Doc Link 12445973 Disease Relevance 0.06 Pain Relevance 1.30
Methadone stimulated the P-gp ATPase activity only at higher concentrations, while verapamil and GF120918 inhibited its efflux (p < 0.05).
Positive_regulation (stimulated) of ATPase associated with methadone
2) Confidence 0.67 Published 2009 Journal J Pharm Sci Section Abstract Doc Link 19370547 Disease Relevance 0.18 Pain Relevance 1.38
The results demonstrated that short-term morphine treatment dose dependently stimulated Na+,K+-ATPase activity.
Positive_regulation (stimulated) of ATPase associated with morphine
3) Confidence 0.66 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16317112 Disease Relevance 0.08 Pain Relevance 0.81
The best-established molecular adaptation to long-term opioid exposure is up-regulation of the cAMP/cAMP-dependent protein kinase (PKA) signaling pathway; this study, therefore, was undertaken to investigate the role of up-regulation of cAMP/PKA signaling pathway in alteration of the mouse hippocampal Na+,K+-ATPase activity.
Spec (investigate) Positive_regulation (up-regulation) of ATPase associated with opioid
4) Confidence 0.66 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16317112 Disease Relevance 0.09 Pain Relevance 0.77
Endomorphin-1 (0.1 nM-10 microM) produced a concentration-dependent (EC(50): 43.19 nM, CI: 23.38-65.71 nM, E(max): 25.86%, CI: 24.53-27.20%), naloxone-reversible increase of the synaptosomal Na(+),K(+)-ATPase activity.
Positive_regulation (increase) of ATPase associated with narcan
5) Confidence 0.59 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12504785 Disease Relevance 0 Pain Relevance 0.35
Additionally, the potential exogenous cannabinoids and endogenous opioid peptides interaction as well as the role of G(i/o) proteins in mediating Na(+),K(+)-ATPase activation were also explored.
Positive_regulation (activation) of ATPase associated with cannabinoid and endogenous opioid
6) Confidence 0.53 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17644088 Disease Relevance 0 Pain Relevance 0.36
These results suggest that the activation of Na+,K+-ATPase plays a role in the supraspinal, but not spinal, antinociceptive effect of morphine.
Positive_regulation (activation) of ATPase in spinal associated with antinociceptive and morphine
7) Confidence 0.50 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12756273 Disease Relevance 0 Pain Relevance 1.12
These results suggest that morphine indirectly enhances Na(+),K(+)-ATPase activity in the brain by activating mu-opioid receptors and G(i/o) proteins.
Positive_regulation (enhances) of ATPase in brain associated with mu opioid receptor and morphine
8) Confidence 0.50 Published 2002 Journal Brain Res. Section Abstract Doc Link 12445973 Disease Relevance 0.08 Pain Relevance 0.98
Naloxone, an opioid antagonist (10(-6) M), added to the synaptosomal medium, antagonized the enhancement of Na(+),K(+)-ATPase activity induced by morphine, producing a parallel shift to the right of the morphine concentration-response curve.
Positive_regulation (induced) of ATPase associated with antagonist, narcan, opioid and morphine
9) Confidence 0.50 Published 2002 Journal Brain Res. Section Abstract Doc Link 12445973 Disease Relevance 0.06 Pain Relevance 1.30
Mechanisms involved in morphine-induced activation of synaptosomal Na+,K+-ATPase.
Positive_regulation (activation) of ATPase associated with morphine
10) Confidence 0.50 Published 2002 Journal Brain Res. Section Title Doc Link 12445973 Disease Relevance 0 Pain Relevance 1.11
The regulation of Na+,K+-ATPase activity by morphine treatment seemed to associate with the alteration in phosphorylation level but not to be relevant to the change in abundance of Na+,K+-ATPase.
Positive_regulation (abundance) of ATPase associated with morphine
11) Confidence 0.48 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16317112 Disease Relevance 0 Pain Relevance 0.84
Diabetic mice showed a significant increase in Na(+)-K(+)-ATPase activity at 3 weeks after streptozotocin treatment, whereas Na(+)-K(+)-ATPase activity was decreased at 12 weeks after treatment.
Positive_regulation (increase) of ATPase associated with diabetes mellitus
12) Confidence 0.47 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18834878 Disease Relevance 1.11 Pain Relevance 0.48
From each series (morphine and meperidine analogs) we selected potential candidate opioids that are non-P-gp substrates and conducted in vivo assessments of their antinociceptive effects using P-gp knockout and P-gp competent mice. 6-Desoxymorphine, meperidine and N-phenylbutyl normeperidine did not significantly (p>0.05) stimulate the basal P-gp ATPase activity, where, the fold stimulations of the basal P-gp ATPase activity were 1.01+/-0.11, 1.51+/-0.29 and 1.10+/-0.23, respectively.
Positive_regulation (stimulations) of ATPase associated with targeted disruption, antinociceptive, opioid and morphine
13) Confidence 0.47 Published 2009 Journal Int J Pharm Section Abstract Doc Link 19481690 Disease Relevance 0.15 Pain Relevance 1.40
From each series (morphine and meperidine analogs) we selected potential candidate opioids that are non-P-gp substrates and conducted in vivo assessments of their antinociceptive effects using P-gp knockout and P-gp competent mice. 6-Desoxymorphine, meperidine and N-phenylbutyl normeperidine did not significantly (p>0.05) stimulate the basal P-gp ATPase activity, where, the fold stimulations of the basal P-gp ATPase activity were 1.01+/-0.11, 1.51+/-0.29 and 1.10+/-0.23, respectively.
Neg (not) Positive_regulation (stimulate) of ATPase associated with targeted disruption, antinociceptive, opioid and morphine
14) Confidence 0.47 Published 2009 Journal Int J Pharm Section Abstract Doc Link 19481690 Disease Relevance 0.15 Pain Relevance 1.46
Norepinephrine-sensitive ATPase activity was also restored partially in precipitated withdrawal animals.
Spec (partially) Positive_regulation (restored) of ATPase associated with withdrawal
15) Confidence 0.46 Published 1979 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 215749 Disease Relevance 0 Pain Relevance 1.33
The dopamine-sensitive Na+,K+-ATPase activity was restored by 50% in precipitated withdrawal mouse brain synaptosomes.
Positive_regulation (restored) of ATPase in brain associated with dopamine and withdrawal
16) Confidence 0.46 Published 1979 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 215749 Disease Relevance 0 Pain Relevance 1.37
Pertussis toxin (G(i/o) protein blocker) treatment at a dose of 0.5 microg/mouse, administered i.c.v. 5 days before the synaptosomes were obtained, completely abolished the enhancement of Na(+),K(+)-ATPase activity induced by morphine.
Positive_regulation (induced) of ATPase associated with bordatella infection and morphine
17) Confidence 0.46 Published 2002 Journal Brain Res. Section Abstract Doc Link 12445973 Disease Relevance 0.10 Pain Relevance 1.20
Involvement of cAMP/cAMP-dependent protein kinase signaling pathway in regulation of Na+,K+-ATPase upon activation of opioid receptors by morphine.
Positive_regulation (activation) of ATPase associated with opioid receptor and morphine
18) Confidence 0.45 Published 2006 Journal Mol. Pharmacol. Section Title Doc Link 16317112 Disease Relevance 0.09 Pain Relevance 0.77
Evaluation of endomorphin-1 on the activity of Na(+),K(+)-ATPase using in vitro and in vivo studies.
Positive_regulation (Evaluation) of ATPase associated with analgesic
19) Confidence 0.43 Published 2003 Journal Eur. J. Pharmacol. Section Title Doc Link 12504785 Disease Relevance 0 Pain Relevance 0.52
Role of cannabinoid CB1 receptors and Gi/o protein activation in the modulation of synaptosomal Na+,K+-ATPase activity by WIN55,212-2 and delta(9)-THC.
Positive_regulation (activation) of ATPase associated with cannabinoid and narcan
20) Confidence 0.38 Published 2007 Journal Eur. J. Pharmacol. Section Title Doc Link 17644088 Disease Relevance 0 Pain Relevance 0.40

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