INT15580

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Context Info
Confidence 0.44
First Reported 1991
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 7.59
Pain Relevance 1.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (TCN2) extracellular region (TCN2)
Anatomy Link Frequency
salivary glands 2
LEK 1
vasculature 1
pancreas 1
unspecified 1
TCN2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 5 100.00 Very High Very High Very High
Inflammatory response 24 97.00 Very High Very High Very High
Clonidine 3 96.16 Very High Very High Very High
chemokine 12 93.28 High High
anesthesia 1 87.52 High High
Angina 13 82.80 Quite High
antagonist 4 78.16 Quite High
Neuropeptide 2 75.00 Quite High
Inflammation 209 72.40 Quite High
agonist 4 69.32 Quite High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 42 99.98 Very High Very High Very High
Infection 44 99.90 Very High Very High Very High
Hypertension 152 97.92 Very High Very High Very High
Obesity 36 97.80 Very High Very High Very High
Salivary Gland Disease 66 97.52 Very High Very High Very High
INFLAMMATION 208 96.82 Very High Very High Very High
Anaemia 4 95.72 Very High Very High Very High
Diarrhoea 3 94.92 High High
Parasitemia 7 94.48 High High
Failure To Thrive 1 94.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Serum cobalamin binding capacity showed no detectable transcobalamin II.
Neg (no) Gene_expression (detectable) of transcobalamin II
1) Confidence 0.44 Published 1991 Journal Eur. J. Pediatr. Section Abstract Doc Link 1743216 Disease Relevance 0.29 Pain Relevance 0.09
Single infections by TCII (unspecified sublineage) (32.1%) and TCI (28%) as well as Z3 (TCIIa) (7.1%) were most commonly observed, however, mixed infections TCI/TCII (10.7%) and TCI/Z3 (TCIIa) (3.6%) were also detected.
Gene_expression (detected) of TCII in unspecified associated with infection
2) Confidence 0.21 Published 2009 Journal Veterinary Research Section Body Doc Link PMC2695024 Disease Relevance 0.65 Pain Relevance 0
Studies in Africa and the USA have shown higher vitamin B12 and transcobalamin II levels in black than in white individuals.
Gene_expression (levels) of transcobalamin II in B12
3) Confidence 0.08 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2941760 Disease Relevance 1.18 Pain Relevance 0.06
Post-operatively, TIMI II and TIMI III flow were established in two and 41 patients, respectively.
Gene_expression (established) of TIMI II
4) Confidence 0.03 Published 2003 Journal Int. J. Cardiol. Section Abstract Doc Link 14659866 Disease Relevance 0.48 Pain Relevance 0.08
Fibric acids increase HDL-C partly by increasing apolipoprotein A-I and apolipoprotein A-II gene expression.
Gene_expression (expression) of A-II associated with disorder of lipid metabolism
5) Confidence 0.02 Published 2006 Journal Cardiovasc Diabetol Section Body Doc Link PMC1592077 Disease Relevance 0.87 Pain Relevance 0.03
In fact, vascular inflammatory response has been shown to be more closely related to local AT II than circulating AT II, and recent studies tried to elucidate the consequences of increased AT II production within specific organs (heart, vasculature, pancreas, adipose tissue) (Bader et al 2001; Fleming et al 2006).
Gene_expression (production) of AT II in heart associated with inflammatory response and obesity
6) Confidence 0.02 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464748 Disease Relevance 0.54 Pain Relevance 0.17
These data indicate that there is a remarkable production of AT II by tissues and that a complete suppression of the RAS cannot be achieved by ACE inhibition alone (Petrie et al 2001).
Gene_expression (production) of AT II
7) Confidence 0.02 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464748 Disease Relevance 0.50 Pain Relevance 0.20
The key enzyme that regulates the local generation of AT II is the angiotensin-converting enzyme (ACE).
Gene_expression (generation) of AT II
8) Confidence 0.02 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464748 Disease Relevance 0.46 Pain Relevance 0.08
Before the treatment, the patient group had lower levels of beta-EP and LEK (P < 0.001), higher levels of AVP, PRA and AT-II (P < 0.05-0.01), as compared with those in control group.
Gene_expression (levels) of AT-II in LEK associated with enkephalin
9) Confidence 0.01 Published 1993 Journal Zhonghua Xin Xue Guan Bing Za Zhi Section Abstract Doc Link 8243225 Disease Relevance 0.17 Pain Relevance 0.69
Increased levels of Ang I and II could also lead to increased levels of biologically active Ang fragments.2 Therefore, direct renin inhibition may be a more optimal pharmacologic approach to RAAS inhibition by interrupting the system at its first regulated step.6
Gene_expression (levels) of and II
10) Confidence 0.01 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2952455 Disease Relevance 0.26 Pain Relevance 0.04
The authors concluded that IRAC I and IRAC II are not alleles but rather co-expressed members of a multigene family.
Neg (not) Gene_expression (expressed) of IRAC II
11) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0.19 Pain Relevance 0
Messengers for IRAC I, IRAC II, IxAC-B1, IxAC-B3 and IxAC-B5 were detected in unfed females and the complete repertoire was detected in salivary glands from females on day 3 of the bloodmeal and on day 5 (Figure 10b).
Gene_expression (detected) of IRAC II in salivary glands associated with salivary gland disease
12) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0.16 Pain Relevance 0
IRAC I, IRAC II, IxAC-B1, B3 and B5 messengers were detected in unfed females and the complete repertoire was detected in salivary glands from pooled females at days 3 and 5 of the bloodmeal.
Gene_expression (detected) of IRAC II in salivary glands associated with salivary gland disease
13) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0.22 Pain Relevance 0
In fact, vascular inflammatory response has been shown to be more closely related to local AT II than circulating AT II, and recent studies tried to elucidate the consequences of increased AT II production within specific organs (heart, vasculature, pancreas, adipose tissue) (Bader et al 2001; Fleming et al 2006).
Gene_expression (production) of AT II in vasculature associated with inflammatory response and obesity
14) Confidence 0.01 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464748 Disease Relevance 0.54 Pain Relevance 0.17
In fact, vascular inflammatory response has been shown to be more closely related to local AT II than circulating AT II, and recent studies tried to elucidate the consequences of increased AT II production within specific organs (heart, vasculature, pancreas, adipose tissue) (Bader et al 2001; Fleming et al 2006).
Gene_expression (production) of AT II in adipose tissue associated with inflammatory response and obesity
15) Confidence 0.01 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464748 Disease Relevance 0.54 Pain Relevance 0.17
In fact, vascular inflammatory response has been shown to be more closely related to local AT II than circulating AT II, and recent studies tried to elucidate the consequences of increased AT II production within specific organs (heart, vasculature, pancreas, adipose tissue) (Bader et al 2001; Fleming et al 2006).
Gene_expression (production) of AT II in pancreas associated with inflammatory response and obesity
16) Confidence 0.01 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464748 Disease Relevance 0.54 Pain Relevance 0.17

General Comments

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