INT155801

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Context Info
Confidence 0.59
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 3.97
Pain Relevance 1.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Dtnbp1) endoplasmic reticulum (Dtnbp1) plasma membrane (Dtnbp1)
nucleus (Dtnbp1) cytoplasm (Dtnbp1)
Anatomy Link Frequency
cortex 2
hippocampal formation 1
synaptic cleft 1
hippocampus 1
Dtnbp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 18 98.80 Very High Very High Very High
Dopamine 36 97.40 Very High Very High Very High
cerebral cortex 4 97.36 Very High Very High Very High
addiction 121 95.80 Very High Very High Very High
Nicotine 52 95.36 Very High Very High Very High
opiate 64 91.64 High High
agonist 4 89.24 High High
Glutamate receptor 4 88.92 High High
Glutamate 18 84.36 Quite High
Eae 4 70.96 Quite High
Disease Link Frequency Relevance Heat
Schizophrenia 183 99.92 Very High Very High Very High
Nicotine Addiction 44 95.80 Very High Very High Very High
Post-traumatic Stress Disorder 72 94.84 High High
Disease 18 92.56 High High
Opiate Addiction 52 92.08 High High
Anxiety Disorder 38 80.72 Quite High
Cognitive Disorder 13 55.52 Quite High
Psychosis 32 50.00 Quite Low
Manic Depressive Disorder 12 45.12 Quite Low
Congenital Anomalies 6 40.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dysbindin-1 mRNA and protein levels are significantly reduced in the prefrontal cortex and hippocampus of schizophrenia subjects.
Negative_regulation (reduced) of Dysbindin-1 in hippocampus associated with hippocampus and schizophrenia
1) Confidence 0.59 Published 2009 Journal Behav. Brain Res. Section Abstract Doc Link 18984010 Disease Relevance 0.29 Pain Relevance 0.08
Reduced DTNBP1 mRNA and protein expression has been found in the hippocampal formation and dorsolateral prefrontal cortex of schizophrenia patients [11-13].
Negative_regulation (Reduced) of DTNBP1 in cortex associated with schizophrenia
2) Confidence 0.43 Published 2010 Journal Behav Brain Funct Section Body Doc Link PMC2911395 Disease Relevance 0.84 Pain Relevance 0.22
Given this, it is possible that rs9370822 results in a reduction of DTNBP1 function resulting in a recessive loss-of-function pattern in certain disorders, presumably because the loss of function from one allele is not sufficient to increase susceptibility to disease detectably but loss of function of both alleles does.
Negative_regulation (reduction) of DTNBP1 associated with disease
3) Confidence 0.43 Published 2010 Journal Behav Brain Funct Section Body Doc Link PMC2911395 Disease Relevance 0.87 Pain Relevance 0.33
A study has also found that dysbindin deficiency can increase the level of cell surface DRD2 and enhance DRD2 signalling [34].


Negative_regulation (deficiency) of dysbindin
4) Confidence 0.42 Published 2010 Journal Behav Brain Funct Section Body Doc Link PMC2911395 Disease Relevance 0.71 Pain Relevance 0.37
Interestingly, we also discovered decreased width of the synaptic cleft in sdy (Fig. 5 C).
Negative_regulation (decreased) of sdy in synaptic cleft
5) Confidence 0.37 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2396815 Disease Relevance 0.05 Pain Relevance 0.18
Schizophrenia patients showed reduced presynaptic DTNBP1 which was related to glutamatergic alterations in intrinsic hippocampal formation connections [11].
Negative_regulation (reduced) of DTNBP1 in hippocampal formation associated with schizophrenia
6) Confidence 0.37 Published 2010 Journal Behav Brain Funct Section Body Doc Link PMC2911395 Disease Relevance 0.93 Pain Relevance 0.24
Dysbindin-1 mRNA and protein levels are significantly reduced in the prefrontal cortex and hippocampus of schizophrenia subjects.
Negative_regulation (reduced) of Dysbindin-1 in cortex associated with hippocampus and schizophrenia
7) Confidence 0.20 Published 2009 Journal Behav. Brain Res. Section Abstract Doc Link 18984010 Disease Relevance 0.29 Pain Relevance 0.08

General Comments

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