INT155807

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Context Info
Confidence 0.40
First Reported 2001
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 5.13
Pain Relevance 1.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ccl4) extracellular region (Ccl4)
Anatomy Link Frequency
macrophage 7
liver 2
microglia 1
Ccl4 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 231 100.00 Very High Very High Very High
chemokine 195 100.00 Very High Very High Very High
cytokine 57 100.00 Very High Very High Very High
fibrosis 77 99.96 Very High Very High Very High
Inflammatory response 44 99.28 Very High Very High Very High
rheumatoid arthritis 27 98.88 Very High Very High Very High
Arthritis 9 94.40 High High
corticosteroid 5 88.04 High High
methotrexate 1 86.04 High High
Inflammatory mediators 16 82.72 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 292 100.00 Very High Very High Very High
Fibrosis 103 99.96 Very High Very High Very High
Rheumatoid Arthritis 27 98.88 Very High Very High Very High
Injury 116 98.84 Very High Very High Very High
Poisoning 10 97.92 Very High Very High Very High
Stress 2 96.48 Very High Very High Very High
Arthritis 9 94.40 High High
Hepatotoxicity 12 93.28 High High
Infection 18 91.60 High High
Hepatitis 10 82.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In particular, the relatively high expression of heme oxygenase 1 after 3 days represents persistent reactive oxygen species production from cell debris, while the high CCL2 and CCL4 expression characterize the inflammatory response associated with strong macrophage activity.
Positive_regulation (high) of Gene_expression (expression) of CCL4 in macrophage associated with inflammatory response
1) Confidence 0.40 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2997608 Disease Relevance 0.41 Pain Relevance 0.25
Interestingly, AC markedly upregulated hepatic HO-1 expression in CCl4-treated mice, which might provide anti-oxidative activity in the liver.
Positive_regulation (upregulated) of Gene_expression (expression) of CCl4 in liver
2) Confidence 0.37 Published 2009 Journal Food Chem. Toxicol. Section Abstract Doc Link 18984026 Disease Relevance 0.46 Pain Relevance 0.09
improved experimental CCl4-induced fibrosis [43] led us to explore the involvement of TNF-?
Positive_regulation (improved) of Gene_expression (improved) of CCl4 associated with fibrosis
3) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892485 Disease Relevance 0.84 Pain Relevance 0.05
improved experimental CCl4-induced fibrosis [43] led us to explore the involvement of TNF-?
Positive_regulation (induced) of Gene_expression (improved) of CCl4 associated with fibrosis
4) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892485 Disease Relevance 0.84 Pain Relevance 0.05
Additional studies demonstrated the expression of CCL3 and CCL4 in macrophages and microglia, and CCL3 also in astrocytes [47-49].
Positive_regulation (demonstrated) of Gene_expression (expression) of CCL4 in macrophages
5) Confidence 0.28 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.31 Pain Relevance 0.22
In conclusion, this study demonstrates the expression of CCL2, CXCL10, CCL4, CXCL9, and CXCL8 in ST of RA patients.
Positive_regulation (demonstrates) of Gene_expression (expression) of CCL4 associated with rheumatoid arthritis
6) Confidence 0.27 Published 2001 Journal Arthritis Res Section Body Doc Link PMC17826 Disease Relevance 0.90 Pain Relevance 0.53
Engagement of various TLRs by specific PAMPs leads to production and release of cytokines
         (such as TNF and the interleukins IL- 1 and IL-6) and chemokines (such as IL-8, and the
         ‘macrophage inflammatory proteins’ CCL3 and CCL4) (Ref. 12). 
Positive_regulation (leads) of Gene_expression (production) of CCL4 in macrophage associated with chemokine, inflammation and cytokine
7) Confidence 0.16 Published 2008 Journal Expert Reviews in Molecular Medicine Section Body Doc Link PMC2586610 Disease Relevance 1.07 Pain Relevance 0.48
Additional studies demonstrated the expression of CCL3 and CCL4 in macrophages and microglia, and CCL3 also in astrocytes [47-49].
Positive_regulation (demonstrated) of in microglia Gene_expression (expression) of CCL4 in macrophages
8) Confidence 0.09 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.31 Pain Relevance 0.22

General Comments

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