INT155833

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Context Info
Confidence 0.58
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 17
Disease Relevance 15.28
Pain Relevance 2.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Cma1) extracellular region (Cma1) intracellular (Cma1)
Anatomy Link Frequency
mast cells 9
embryo 3
cleavage 1
fibroblast 1
connective tissue 1
Cma1 (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 156 99.32 Very High Very High Very High
metalloproteinase 2 98.32 Very High Very High Very High
Osteoarthritis 149 97.52 Very High Very High Very High
Inflammation 331 91.12 High High
agonist 5 82.76 Quite High
cytokine 15 82.32 Quite High
rheumatoid arthritis 102 79.60 Quite High
Inflammatory response 69 75.04 Quite High
substance P 15 72.48 Quite High
chemokine 42 71.44 Quite High
Disease Link Frequency Relevance Heat
Stress 101 99.96 Very High Very High Very High
Fibrosis 401 99.40 Very High Very High Very High
Hypoxia 279 99.36 Very High Very High Very High
Calcification 63 99.28 Very High Very High Very High
Metaplasia 72 99.08 Very High Very High Very High
Urinary Dysfunction 13 98.96 Very High Very High Very High
Disease 83 98.20 Very High Very High Very High
Injury 230 97.96 Very High Very High Very High
Osteoarthritis 149 97.52 Very High Very High Very High
Systemic Sclerosis 45 97.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, the zymogen forms of the matrix metalloproteinases prostromelysin and procollagenase are activated by specific MC subsets that either express tryptase (MCT) or tryptase and chymase (MCTC) [48,49].
Gene_expression (express) of chymase associated with metalloproteinase
1) Confidence 0.58 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 0.58 Pain Relevance 0.28
Mast cell proteases mcpt-5 (chymase), and the tryptases mcpt-6 and mcpt-7 are all expressed during the development of the mouse embryo [63].
Gene_expression (expressed) of Mast cell proteases mcpt-5 in embryo
2) Confidence 0.55 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2000913 Disease Relevance 0.28 Pain Relevance 0.20
Mast cell proteases mcpt-5 (chymase), and the tryptases mcpt-6 and mcpt-7 are all expressed during the development of the mouse embryo [63].
Gene_expression (expressed) of chymase in embryo
3) Confidence 0.55 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2000913 Disease Relevance 0.28 Pain Relevance 0.17
These data suggest that Mcpt5 is initially expressed independently of signals from macrophages and neutrophils, but that leukocytes are subsequently responsible for a secondary expression, either directly by expressing Mcp5 themselves, or indirectly by triggering expression in another cell type, possibly supplying cues that reinforce expression by mast cells or prevent their dispersal from the wound site.
Gene_expression (expressed) of Mcpt5 in mast cells associated with injury
4) Confidence 0.52 Published 2005 Journal Genome Biol Section Body Doc Link PMC549066 Disease Relevance 0.82 Pain Relevance 0.22
While human connective tissue mast cells contain the enzymes chymase and tryptase, mice contain numerous related proteases [63-65].
Gene_expression (contain) of chymase in connective tissue
5) Confidence 0.48 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2000913 Disease Relevance 0.40 Pain Relevance 0.21
Real-time polymerase chain reaction analysis detected mRNA of mucosal mast cell chymases 4 and 5, endothelin-converting enzyme 1a, and neutral endopeptidase 24.11 in pulmonary, cardiac, and aorta homogenates derived from C57BL/6J mice, with the latter tissue expressing the highest levels of both chymase isoforms.
Gene_expression (expressing) of chymase in mast cell
6) Confidence 0.46 Published 2009 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18987301 Disease Relevance 0 Pain Relevance 0
The fibrotic tissue also contained nitrosylated proteins concordant with elevated numbers of chymase and FGF producing mast cells, indicative of oxidative stress and increased fibroproliferative factors driving cell survival and proliferation.
Gene_expression (producing) of chymase in mast cells associated with stress and fibrosis
7) Confidence 0.46 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940819 Disease Relevance 1.13 Pain Relevance 0.06
The presence of chymase, a proteolytic enzyme, and the cleavage and activation of TGF-?
Gene_expression (presence) of chymase in cleavage
8) Confidence 0.46 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940819 Disease Relevance 1.51 Pain Relevance 0.05
Mast cell proliferation and activation and increased expression of chymase have also been linked to fibroproliferative diseases, such as systemic sclerosis, a fibrotic disorder of connective tissue, and neurogenic bladder fibrosis [32,33,35].
Gene_expression (expression) of chymase in Mast cell associated with fibrosis, urinary dysfunction, systemic sclerosis and disease
9) Confidence 0.46 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940819 Disease Relevance 1.40 Pain Relevance 0.05
In the same areas, increased numbers of chymase expressing mast cells were observed (Figure 4C, D).
Gene_expression (expressing) of chymase in mast cells
10) Confidence 0.35 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940819 Disease Relevance 0.89 Pain Relevance 0.21
All three of these fibrotic diseases undergo metaplastic changes that progress to tissue calcification, suggesting an association between chymase-expressing mast cells and tissue metaplasia.
Gene_expression (expressing) of chymase in mast cells associated with fibrosis, calcification, metaplasia and disease
11) Confidence 0.35 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940819 Disease Relevance 2.08 Pain Relevance 0.14
Chymase-expressing mast cells are generally classified as non-immune mast cells, differentiating them from mast cells that only express tryptase and that are involved in allergic and parasitic diseases [34].
Gene_expression (expressing) of Chymase in mast cells associated with parasitic infection and hypersensitivity
12) Confidence 0.35 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940819 Disease Relevance 0.98 Pain Relevance 0.04
Within the fibrotic regions, elevated numbers of chymase/fibroblast growth factor (FGF)-expressing mast cells were observed.
Gene_expression (expressing) of chymase in fibroblast associated with fibrosis
13) Confidence 0.35 Published 2010 Journal Fibrogenesis Tissue Repair Section Abstract Doc Link PMC2940819 Disease Relevance 1.07 Pain Relevance 0
In summary, our data implicates oxidative stress, chymase-expressing mast cells and hypoxia as driving forces for fibrosis and the metaplastic changes observed.
Gene_expression (expressing) of chymase in mast cells associated with stress, fibrosis and hypoxia
14) Confidence 0.35 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940819 Disease Relevance 2.37 Pain Relevance 0.19
In fibroproliferative disorders of the skin and gastrointestinal tract, mast cells undergo proliferation and activation, and show increased expression of mast cell-specific chymase [32-35].
Gene_expression (expression) of chymase in mast cell
15) Confidence 0.31 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940819 Disease Relevance 0.97 Pain Relevance 0.04
Mast cell proteases mcpt5 (chymase), mcpt6 and 7 (tryptases) are expressed during the development of the mouse embryo [49].
Gene_expression (expressed) of chymase in embryo
16) Confidence 0.18 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853108 Disease Relevance 0.44 Pain Relevance 0.18
This was used to detect intracellular chymase, TNF-?
Gene_expression (detect) of chymase
17) Confidence 0.09 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350147 Disease Relevance 0.08 Pain Relevance 0

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