INT155838

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Context Info
Confidence 0.47
First Reported 2006
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 7
Total Number 12
Disease Relevance 13.27
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (GGT1) plasma membrane (GGT1) transferase activity, transferring acyl groups (GGT1)
cellular amino acid metabolic process (GGT1)
Anatomy Link Frequency
liver 3
blood 1
GGT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
alcohol 32 99.16 Very High Very High Very High
fibrosis 103 96.92 Very High Very High Very High
diabetic neuropathy 54 90.56 High High
Angina 2 87.12 High High
Inflammation 32 78.12 Quite High
Bile 5 64.68 Quite High
Kinase C 18 57.20 Quite High
Pain 15 45.40 Quite Low
pruritus 1 42.40 Quite Low
Bioavailability 6 35.68 Quite Low
Disease Link Frequency Relevance Heat
Neuropathy 408 100.00 Very High Very High Very High
Stress 156 100.00 Very High Very High Very High
Liver Disease 14 99.76 Very High Very High Very High
Prehypertension 12 99.76 Very High Very High Very High
Disorder Of Lipid Metabolism 68 99.32 Very High Very High Very High
Alcoholic Liver Diseases 8 99.20 Very High Very High Very High
Cardiovascular Disease 35 99.12 Very High Very High Very High
Chronic Hepatitis 6 98.28 Very High Very High Very High
Diabetes Mellitus 116 98.12 Very High Very High Very High
Metabolic Syndrome 88 97.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We performed a cross-sectional study to examine whether serum GGT was associated with prehypertension.
GGT Binding (associated) of associated with prehypertension
1) Confidence 0.47 Published 2008 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 18987455 Disease Relevance 1.12 Pain Relevance 0.13
GGT has been known mainly as a marker of alcohol consumption or liver diseases, and serum GGT within normal ranges has been reported to be associated with risk factors of cardiovascular diseases and components of metabolic syndrome [21].
GGT Binding (associated) of in liver associated with liver disease, cardiovascular disease, metabolic syndrome and alcohol
2) Confidence 0.47 Published 2010 Journal Korean Diabetes Journal Section Body Doc Link PMC2883349 Disease Relevance 1.19 Pain Relevance 0.24
The two panel markers for the prediction of activity and fibrosis were the same as those validated in patients with chronic hepatitis C [28], B [25,29] and alcoholic liver disease [30]: 1) FibroTest (FT) includes total bilirubin, GGT, ?
GGT Binding (bilirubin) of in liver associated with fibrosis, chronic hepatitis and alcoholic liver diseases
3) Confidence 0.36 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1386692 Disease Relevance 1.37 Pain Relevance 0.30
Gamma-glutamyltransferase (GGT), alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and bilirubin were analyzed, using a VitrosĀ® 950 chemistry system (Ortho Clinical Diagnostics, Rochester, NY, USA).


GGT Binding (bilirubin) of
4) Confidence 0.36 Published 2008 Journal Eur J Nucl Med Mol Imaging Section Body Doc Link PMC2440967 Disease Relevance 0.06 Pain Relevance 0
At our hospital GGT is not included in routine liver function tests, and needs to be specifically requested.
GGT Binding (hospital) of in liver
5) Confidence 0.36 Published 2008 Journal Cases J Section Body Doc Link PMC2475516 Disease Relevance 0.78 Pain Relevance 0.06
Previous studies have showed that there is a positive association between dietary factors and GGT levels [25].
GGT Binding (association) of
6) Confidence 0.36 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2831093 Disease Relevance 0.32 Pain Relevance 0.05
The analysis for correlation of serum GGT with clinical and biochemical characteristics of the subjects indicated that gender, 2PPBG, and total cholesterol concentration were significantly associated with serum GGT level with a positive correlation (Table 2).


GGT Binding (associated) of associated with disorder of lipid metabolism
7) Confidence 0.36 Published 2010 Journal Korean Diabetes Journal Section Body Doc Link PMC2883349 Disease Relevance 0.92 Pain Relevance 0
Therefore, we investigated whether serum GGT as a sensitive marker of oxidative stress which was considered to be part of pathophysiology of DPP might be significantly associated with the presence of polyneuropathy in type 2 diabetic patients.
GGT Spec (might) Binding (associated) of associated with neuropathy, stress and diabetes mellitus
8) Confidence 0.36 Published 2010 Journal Korean Diabetes Journal Section Body Doc Link PMC2883349 Disease Relevance 2.00 Pain Relevance 0.04
The inverse associations between antioxidants and serum GGT according to venous sampling analysis have indicated the possibility that serum GGT might be associated with oxidative stress [21,23].
GGT Spec (might) Binding (associated) of associated with stress
9) Confidence 0.35 Published 2010 Journal Korean Diabetes Journal Section Body Doc Link PMC2883349 Disease Relevance 1.07 Pain Relevance 0.13
We evaluated the association between serum GGT and the presence of DPP.


GGT Binding (association) of associated with neuropathy
10) Confidence 0.35 Published 2010 Journal Korean Diabetes Journal Section Abstract Doc Link PMC2883349 Disease Relevance 2.00 Pain Relevance 0
Recent guidelines classify persons with above-optimal blood pressure (BP) but not clinical hypertension as having prehypertension for a systolic BP (SBP) of 120 to 139 mmHg and/or a diastolic BP (DBP) of 80 to 89 mmHg; however, only limited data are available on the association between serum GGT and this entity among community-dwelling men in Japan.
GGT Binding (association) of in blood associated with prehypertension and hypertension
11) Confidence 0.35 Published 2008 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 18987455 Disease Relevance 1.06 Pain Relevance 0.12
Only increased level of serum GGT remained independently associated with the presence of DPP, which carried a relative risk with an odds ratio of 1.1 (P < 0.01) (Table 5).


GGT Binding (associated) of associated with neuropathy
12) Confidence 0.35 Published 2010 Journal Korean Diabetes Journal Section Body Doc Link PMC2883349 Disease Relevance 1.40 Pain Relevance 0.05

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