INT15584

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Context Info
Confidence 0.48
First Reported 1991
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 14
Total Number 16
Disease Relevance 15.14
Pain Relevance 3.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (S100A12) extracellular region (S100A12) nucleus (S100A12)
cytoplasm (S100A12)
Anatomy Link Frequency
granulocytes 1
smooth muscle 1
sustentacular cells 1
muscle 1
bowel 1
S100A12 (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 2 100.00 Very High Very High Very High
Serotonin 1 100.00 Very High Very High Very High
Crohn's disease 211 99.80 Very High Very High Very High
spastic colon 145 99.48 Very High Very High Very High
Inflammation 200 98.88 Very High Very High Very High
headache 2 94.32 High High
cytokine 42 91.68 High High
Pain 18 88.08 High High
Arthritis 25 80.40 Quite High
imagery 23 80.32 Quite High
Disease Link Frequency Relevance Heat
Disease 505 99.80 Very High Very High Very High
Functional Bowel Disorder 19 99.48 Very High Very High Very High
Carcinoma 5 99.48 Very High Very High Very High
Neurilemmoma 9 99.46 Very High Very High Very High
INFLAMMATION 208 98.88 Very High Very High Very High
Inflammatory Bowel Disease 505 98.72 Very High Very High Very High
Hematuria 1 98.08 Very High Very High Very High
Cancer 109 97.76 Very High Very High Very High
Overactive Bladder 1 95.96 Very High Very High Very High
Necrosis 9 95.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Spearman correlation coefficients were used to explore the association of S100A12 with SAA and CRP values, CDAI and CAI, as well as disease duration.
S100A12 Binding (association) of associated with disease
1) Confidence 0.48 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2964606 Disease Relevance 0.54 Pain Relevance 0.09
Thus, it seems that further research in larger populations is mandatory, in order to verify these results, examine the association of serum S100A12 with disease or patients' characteristics and specify whether serum S100A12 could be added in the existing armamentarium, used for the diagnosis of IBD.


S100A12 Spec (examine) Binding (association) of associated with inflammatory bowel disease and disease
2) Confidence 0.48 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2964606 Disease Relevance 0.44 Pain Relevance 0.04
The performed analysis showed no associations between S100A12 and CD behavior, since patients with stricturing (median: 62.1 ng/mL, range: 32-141.2 ng/mL), penetrating (median: 73.5 ng/mL, range: 41.2-136.7 ng/mL) or ns/np (median: 78.4 ng/mL, range: 29.3-157.6 ng/mL) disease had comparable levels (P = 0.321).
S100A12 Neg (no) Binding (associations) of associated with crohn's disease and disease
3) Confidence 0.42 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2964606 Disease Relevance 1.37 Pain Relevance 0.26
Immunohistochemical studies revealed positive reactivity for chromogranin (three patients), met-enkephalin (three), leu-enkephalin (three), vasoactive intestinal polypeptide (two), serotonin (one), and S-100 protein (one; sustentacular cells only).
S-100 protein Binding (reactivity) of in sustentacular cells associated with enkephalin and serotonin
4) Confidence 0.37 Published 1991 Journal Hum. Pathol. Section Abstract Doc Link 1743702 Disease Relevance 1.03 Pain Relevance 0.34
The variations in the median of serum S100A12 did not show a significant association with either disease extent, in UC (P = 0.590) or disease location in CD (P = 0.512) (Table 2).
S100A12 Binding (association) of associated with inflammatory bowel disease, crohn's disease and disease
5) Confidence 0.37 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2964606 Disease Relevance 1.34 Pain Relevance 0.19
Likewise, when the association of serum S100A12 with CDAI and CAI was examined no significant correlations emerged (Spearman r: 0.08 and 0.07, respectively and P ?
S100A12 Binding (serum) of
6) Confidence 0.37 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2964606 Disease Relevance 1.12 Pain Relevance 0.26
S100A12 binds to the receptor for advanced glycation end-products, while complexes of S100A8/S100A9 (myeloid-related proteins, MRP8/14; calprotectin) are ligands of toll-like receptor 4.
S100A12 Binding (binds) of
7) Confidence 0.36 Published 2008 Journal J. Pathol. Section Abstract Doc Link 18729068 Disease Relevance 0.35 Pain Relevance 0.17
S100A12, a calcium-binding proinflammatory protein secreted by granulocytes, has been associated with different diseases of inflammatory origin, including inflammatory bowel disease (IBD).
S100A12 Binding (associated) of in bowel associated with inflammatory bowel disease, inflammation and disease
8) Confidence 0.31 Published 2010 Journal BMC Gastroenterol Section Abstract Doc Link PMC2964606 Disease Relevance 1.16 Pain Relevance 0.59
Although two RAGE ligands (S100B and S100A12) also bind Zn++ very well, the effect on them is to increase their affinity for Ca++ [106,107].
S100A12 Binding (bind) of
9) Confidence 0.31 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0 Pain Relevance 0
Is this interaction dependant on the oligomeric state of the S100 protein?
S100 protein Binding (interaction) of
10) Confidence 0.24 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.87 Pain Relevance 0.26
The diagnosis of schwannoma was supported by positive immunoreactivity for S-100 protein and collagen IV and absence of reactivity for keratin, muscle related antigens, and CD34 in both cases.
S-100 protein Binding (immunoreactivity) of in muscle associated with neurilemmoma
11) Confidence 0.21 Published 2006 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 16699318 Disease Relevance 1.18 Pain Relevance 0.17
Immunohistochemical studies showed positive staining of the tumor cells with actin, desmin, and vimentin antibodies, with focal positivity for myoglobin in three cases and focal positive staining with S-100 protein in one case.
S-100 protein Binding (staining) of associated with cancer
12) Confidence 0.17 Published 1994 Journal Hum. Pathol. Section Abstract Doc Link 8163267 Disease Relevance 1.22 Pain Relevance 0.07
The predominant role of the innate immune system in systemic onset disease is also underscored by the high expression and serum concentrations of the calcium-binding proteins S100A8, S100A9, and S100A12, which are specifically secreted during activation of neutrophilic granulocytes and monocytes47).
S100A12 Binding (binding) of in granulocytes associated with disease
13) Confidence 0.12 Published 2010 Journal Korean Journal of Pediatrics Section Body Doc Link PMC3012271 Disease Relevance 1.07 Pain Relevance 0.24
These cells were strongly immunoreactive with CD34, Bcl-2, CD99, and vimentin, but were negative with S100 protein, smooth muscle actin, and epithelial membrane antigen.
S100 protein Binding (negative) of in smooth muscle
14) Confidence 0.12 Published 2004 Journal Arch. Pathol. Lab. Med. Section Abstract Doc Link 14987150 Disease Relevance 0.84 Pain Relevance 0.12
Clear cell carcinoma rarely exhibits positive immunoreaction for S-100 protein [17].
S-100 protein Spec (Clear) Binding (immunoreaction) of associated with carcinoma
15) Confidence 0.11 Published 2008 Journal Skeletal Radiol Section Body Doc Link PMC2257990 Disease Relevance 1.17 Pain Relevance 0.03
The elevated zinc levels have been attributed to excessive binding to serum proteins, e.g., by albumin [171,173], or to overexpression of the zinc-binding S100 protein calprotectin [172,174].
S100 protein Binding (binding) of
16) Confidence 0.03 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872358 Disease Relevance 0.98 Pain Relevance 0.15

General Comments

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