INT155846

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Context Info
Confidence 0.67
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.93
Pain Relevance 1.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (JAK1) cytoskeleton (JAK1) nucleus (JAK1)
cytoplasm (JAK1)
JAK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 46 91.32 High High
Inflammation 42 90.72 High High
Inflammatory mediators 2 86.96 High High
cINOD 8 80.80 Quite High
Fibrositis 54 79.84 Quite High
antagonist 7 76.16 Quite High
rheumatoid arthritis 45 75.64 Quite High
metalloproteinase 1 75.32 Quite High
chemokine 6 69.52 Quite High
methotrexate 24 62.60 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 46 90.72 High High
Obesity 42 82.00 Quite High
Fibromyalgia 54 79.84 Quite High
Rheumatoid Arthritis 46 75.64 Quite High
Disease 50 75.00 Quite High
Necrosis 2 71.00 Quite High
Cancer 3 70.64 Quite High
Demyelinating Disease 12 56.00 Quite High
Fatigue 9 50.36 Quite High
Weight Loss 1 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Given these possible harmful outcomes, a range of novel therapeutically relevant biological targets that include nuclear transcription factor (NF-kappaB), p38 mitogen-activated protein kinases (MAPK) and Janus protein tyrosine kinases and signal transducers and activators of transcription (JAK/STAT) signalling pathways has received growing attention.
Transcription (transcription) of JAK
1) Confidence 0.67 Published 2008 Journal Drugs R D Section Abstract Doc Link 18989991 Disease Relevance 0.50 Pain Relevance 0.33
When IL-6 binds to its receptor, a mechanism is triggered blocking Janus Kinase signal and activator of transcription (JAK/STAT) mediated transcription of IL-1 and TNF-?
Transcription (transcription) of JAK
2) Confidence 0.67 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2891797 Disease Relevance 0.57 Pain Relevance 0.35
the phosphorylation of signal transducers and activators of transcription

(STAT) 1 and 3 as well as Janus kinase 1 (JAK1) and JAK2 in activated

Transcription (transcription) of JAK1
3) Confidence 0.24 Published 2008 Journal PPAR Research Section Body Doc Link PMC2367430 Disease Relevance 0.30 Pain Relevance 0.32
The binding of IL-6R complexed with IL-6 results in homodimerization of gp130 and signal transduction through Janusactivated kinase (JAK)/signal transducers and activators of transcription (STAT) pathways (Heinrich et al 2003).
Transcription (transcription) of JAK
4) Confidence 0.10 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621374 Disease Relevance 0.57 Pain Relevance 0.20

General Comments

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