INT155867

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Context Info
Confidence 0.69
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 2.90
Pain Relevance 0.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (COL1A2) extracellular region (COL1A2) protein binding, bridging (COL1A2)
Anatomy Link Frequency
chondrocytes 1
articular 1
tendon fibroblasts 1
COL1A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 199 96.40 Very High Very High Very High
Pain 46 91.04 High High
Inflammation 29 90.52 High High
metalloproteinase 22 88.80 High High
cytokine 10 75.20 Quite High
cINOD 11 71.52 Quite High
Arthritis 4 66.16 Quite High
Onset of action 4 51.28 Quite High
rheumatoid arthritis 36 50.00 Quite Low
diclofenac 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Overweight 13 97.00 Very High Very High Very High
Osteoarthritis 201 96.40 Very High Very High Very High
Obesity 105 96.28 Very High Very High Very High
Adhesions 127 92.88 High High
Pain 44 91.04 High High
INFLAMMATION 34 90.52 High High
Hypercalcemia 11 77.92 Quite High
Injury 17 66.52 Quite High
Arthritis 8 66.16 Quite High
Hypoxia 21 55.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cell proliferation and mRNA expressions of type I collagen and decorin were then measured.
Transcription (expressions) of type I collagen
1) Confidence 0.69 Published 2009 Journal J. Orthop. Res. Section Abstract Doc Link 18991342 Disease Relevance 0.16 Pain Relevance 0.12
Low-level laser irradiation promotes cell proliferation and mRNA expression of type I collagen and decorin in porcine Achilles tendon fibroblasts in vitro.
Transcription (expression) of type I collagen in tendon fibroblasts
2) Confidence 0.53 Published 2009 Journal J. Orthop. Res. Section Title Doc Link 18991342 Disease Relevance 0.18 Pain Relevance 0.14
Additionaly, the decline of serum beta-C-telopeptide of type I collagen (?
Transcription (beta-C-telopeptide) of type I collagen
3) Confidence 0.31 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682377 Disease Relevance 0.06 Pain Relevance 0.03
Carboxy-terminal propeptide of type I procollagen
Transcription (propeptide) of type I procollagen
4) Confidence 0.22 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC546286 Disease Relevance 0.08 Pain Relevance 0
More relevant to the present study are the reports [4,8] on the mRNA levels of human type I collagen (alpha 2), fibronectin 1, MMP-1, TIMP-1, TGF-?
Transcription (levels) of type I collagen
5) Confidence 0.19 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548295 Disease Relevance 0.82 Pain Relevance 0.04
The RT-PCR analysis showed a dose-dependent effect of leptin on the expression of type 2 collagen. mRNA was strongly overexpressed in chondrocytes collected from normal or overweight patients upon treatment with 100 ng/ml of leptin.
Transcription (expression) of type 2 collagen in chondrocytes associated with overweight
6) Confidence 0.14 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 0.92 Pain Relevance 0.09
The results demonstrated: (a) that expression levels of the catabolic genes MMP-3 and MMP-13 were suppressed and (b) mRNA expression levels of anabolic genes of collagen II, SOX9 and aggrecan were increased.
Transcription (expression) of collagen II
7) Confidence 0.08 Published 2009 Journal Phytochemistry Section Abstract Doc Link 19118849 Disease Relevance 0.27 Pain Relevance 0.33
In vitro, ascorbate and ascorbic acid increased protein and proteoglycan synthesis by articular chondrocytes [64,66,67] and increased the mRNA levels of type I and II collagen [64,68] and aggrecan and ?
Transcription (levels) of type I and II collagen in articular
8) Confidence 0.05 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779427 Disease Relevance 0.41 Pain Relevance 0.21

General Comments

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