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Context Info
Confidence 0.71
First Reported 1991
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.55
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (NPPA) nucleus (NPPA) cytoplasm (NPPA)
Anatomy Link Frequency
neural 1
NPPA (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 4 100.00 Very High Very High Very High
substance P 1 99.92 Very High Very High Very High
Calcitonin gene-related peptide 7 99.80 Very High Very High Very High
addiction 1 95.32 Very High Very High Very High
tolerance 20 94.72 High High
Morphine 1 94.28 High High
Intracerebroventricular 1 91.48 High High
analgesia 1 90.28 High High
Glutamate 1 81.44 Quite High
Analgesic 4 75.00 Quite High
Disease Link Frequency Relevance Heat
Natriuresis 9 100.00 Very High Very High Very High
Diuresis 1 99.64 Very High Very High Very High
Weight Gain 9 91.92 High High
Impaired Glucose Tolerance 20 90.88 High High
Hyperglycemia 3 88.80 High High
Hyperlipidemia 2 88.08 High High
Stress 10 86.16 High High
Obesity 38 82.32 Quite High
Diabetes Mellitus 9 68.04 Quite High
Insulin Resistance 8 52.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Membrane metalloendopeptidase (MMEP; EC; enkephalinase) catalyzes the degradation of endothelins, enkephalins, atrial natriuretic factor, substance P, and other small bioactive peptides.
Protein_catabolism (degradation) of atrial natriuretic factor associated with natriuresis, enkephalin and substance p
1) Confidence 0.71 Published 1991 Journal J. Biol. Chem. Section Abstract Doc Link 1744100 Disease Relevance 0.10 Pain Relevance 0.15
Thiorphan or its prodrugs acetorphan or sinorphan lead to a increase in natriuresis and diuresis by protection of ANP degradation, but without any significant antihypertensive effect.
Protein_catabolism (degradation) of ANP associated with diuresis and natriuresis
2) Confidence 0.64 Published 1991 Journal Ann Pharm Fr Section Abstract Doc Link 1842170 Disease Relevance 0.20 Pain Relevance 0.48
Neutral endopeptidase (EC, NEP) is a Zn-metallopeptidase involved in the degradation of biologically active peptides, notably the enkephalins and atrial natriuretic peptide.
Protein_catabolism (degradation) of natriuretic peptide associated with natriuresis and enkephalin
3) Confidence 0.01 Published 1991 Journal J. Biol. Chem. Section Abstract Doc Link 1985894 Disease Relevance 0.10 Pain Relevance 0.14
In these studies, we propose that AVE7688, Candoxatril, and to a lesser extent Enalapril may be protecting vascular reactivity and neural function by inhibiting neutral endopeptidase and the degradation of C-type natriuretic peptide and calcitonin gene-related peptide [11–13, 20].


Protein_catabolism (degradation) of natriuretic peptide in neural associated with natriuresis and calcitonin gene-related peptide
4) Confidence 0.01 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC2933895 Disease Relevance 1.15 Pain Relevance 0.09

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