INT155878

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Context Info
Confidence 0.62
First Reported 2005
Last Reported 2008
Negated 1
Speculated 1
Reported most in Body
Documents 4
Total Number 14
Disease Relevance 7.57
Pain Relevance 7.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cnr2) plasma membrane (Cnr2) signal transducer activity (Cnr2)
Anatomy Link Frequency
brain 6
striatum 5
spleen 2
midbrain 1
Cnr2 (Mus musculus)
Pain Link Frequency Relevance Heat
depression 401 99.84 Very High Very High Very High
antagonist 200 99.80 Very High Very High Very High
alcohol 277 99.74 Very High Very High Very High
Cannabinoid 169 99.68 Very High Very High Very High
midbrain 44 99.68 Very High Very High Very High
drug abuse 123 99.56 Very High Very High Very High
opiate 12 97.48 Very High Very High Very High
cocaine 67 97.12 Very High Very High Very High
agonist 252 95.68 Very High Very High Very High
Cannabinoid receptor 21 93.68 High High
Disease Link Frequency Relevance Heat
Depression 412 99.84 Very High Very High Very High
Drug Dependence 156 99.56 Very High Very High Very High
Cancer 6 99.20 Very High Very High Very High
Stress 352 98.40 Very High Very High Very High
Glioma 2 95.12 Very High Very High Very High
Malignant Neoplastic Disease 3 93.60 High High
INFLAMMATION 53 88.84 High High
Demyelinating Disease 52 88.72 High High
Recurrence 26 88.04 High High
Pain 26 83.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study we tested the hypothesis that genetic variants of CB2 gene might be associated with depression in a human population and that alteration in CB2 gene expression may be involved in the effects of abused substances including opiates, cocaine and ethanol in rodents.
Regulation (alteration) of Gene_expression (expression) of CB2 gene associated with depression, opiate and cocaine
1) Confidence 0.62 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2241668 Disease Relevance 0.74 Pain Relevance 0.64
In animals that developed alcohol preference, CB2 gene expression was down regulated in the midbrain and striatum suggesting the involvement of CB2-Rs in the effects drugs of abuse.
Regulation (regulated) of Gene_expression (expression) of CB2 gene in striatum associated with midbrain and alcohol
2) Confidence 0.62 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2241668 Disease Relevance 0.50 Pain Relevance 0.68
We then determined more precisely the involvement of CB2 gene expression in separate groups of mice chronically treated with heroin (10 mg/kg) or cocaine (40 mg/kg) or those exposed to varying alcohol consumption.
Spec (determined) Regulation (involvement) of Gene_expression (expression) of CB2 gene associated with alcohol and cocaine
3) Confidence 0.62 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2241668 Disease Relevance 0.43 Pain Relevance 0.55
In mice subjected to the chronic varying alcohol intake paradigm for alcohol preference, there was significant reduction CB2 gene expression in the striatum (P?
Regulation (significant) of Gene_expression (expression) of CB2 gene in striatum associated with alcohol
4) Confidence 0.45 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2241668 Disease Relevance 0.14 Pain Relevance 0.67
0.04), whereas in mice with little preference for drinking alcohol, there were no changes in CB2 gene expression in these brain regions (Fig. 1D).
Neg (no) Regulation (changes) of Gene_expression (expression) of CB2 gene in brain associated with alcohol
5) Confidence 0.45 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2241668 Disease Relevance 0.13 Pain Relevance 0.68
In the assay, we used spleen as positive control because of its high expression of CB2 gene and no cDNA in the TaqMan PCR reaction as negative control.
Regulation (control) of Gene_expression (expression) of CB2 gene in spleen
6) Confidence 0.45 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2241668 Disease Relevance 0 Pain Relevance 0
Effects of CB2-R activation and blockade on anhedonia induced by chronic mild stress (CMS)
Regulation (Effects) of Gene_expression (activation) of CB2-R associated with stress
7) Confidence 0.45 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2241668 Disease Relevance 0.79 Pain Relevance 0.31
The cells were evaluated by Western immunodetection for the expression of CB2 using anti-CB2 antibodies (Santa Cruz) following siRNA treatment.
Regulation (evaluated) of Gene_expression (expression) of CB2
8) Confidence 0.41 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1352348 Disease Relevance 0 Pain Relevance 0
These effects of CB2-R ligands in in vivo behavioral tests are provided as functional evidence of CB2-R in the brain that plays a role in motor function and emotionality tests.
Regulation (effects) of Gene_expression (ligands) of CB2-R in brain
9) Confidence 0.40 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2241668 Disease Relevance 0.32 Pain Relevance 0.54
To further improve understanding of the role of CB2-Rs in the brain, we hypothesized that genetic variants of CB2 gene might be associated with depression in a human population and that alteration in CB2 gene expression may be involved in the effects of abused substances in rodents.
Regulation (alteration) of Gene_expression (expression) of CB2 gene in brain associated with depression
10) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2241668 Disease Relevance 0.76 Pain Relevance 0.49
Involvement of CB2 gene expression in depression and in the effects of abused drugs
Regulation (Involvement) of Gene_expression (expression) of CB2 gene associated with depression
11) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2241668 Disease Relevance 0.67 Pain Relevance 0.51
In this study we tested the hypothesis that genetic variants of the CB2 gene might be associated with depression in a human population and that alteration in CB2 gene expression may be involved in the effects of abused substances, including opiates, cocaine, and ethanol, in rodents.
Regulation (alteration) of Gene_expression (expression) of CB2 associated with depression, opiate and cocaine
12) Confidence 0.27 Published 2008 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 18991891 Disease Relevance 0.76 Pain Relevance 0.64
In animals that developed alcohol preference, CB2 gene expression was down regulated in the midbrain and striatum suggesting the involvement of CB2-Rs in the effects drugs of abuse.
Regulation (regulated) of in midbrain Gene_expression (expression) of CB2 gene in striatum associated with midbrain and alcohol
13) Confidence 0.21 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2241668 Disease Relevance 0.50 Pain Relevance 0.68
Evidence of the involvement of CB2 demonstrated, included, the prevention by CB2 but not CB1 antagonists and down-regulation of the CB2 receptor but not CB1 in the tumours themselves.
Regulation (regulation) of Gene_expression (receptor) of CB2 associated with cancer and antagonist
14) Confidence 0.17 Published 2006 Journal BMC Neurol Section Body Doc Link PMC1413551 Disease Relevance 1.83 Pain Relevance 0.84

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