INT15588

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Context Info
Confidence 0.26
First Reported 1991
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.48
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (PHEX) protein modification process (PHEX) Golgi apparatus (PHEX)
endoplasmic reticulum (PHEX) plasma membrane (PHEX) cell-cell signaling (PHEX)
Anatomy Link Frequency
endometrium 1
PHEX (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 5 94.12 High High
substance P 1 92.52 High High
corticosteroid 23 91.92 High High
abdominal pain 3 57.60 Quite High
Central nervous system 1 50.76 Quite High
Inflammation 5 24.24 Low Low
antagonist 3 20.80 Low Low
Action potential 7 5.00 Very Low Very Low Very Low
agonist 5 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myasthenia Gravis 168 99.84 Very High Very High Very High
Rickets 1 97.32 Very High Very High Very High
Natriuresis 1 93.32 High High
Osteoporosis 3 91.48 High High
Adhesions 45 82.80 Quite High
Pressure Volume 2 Under Development 2 61.44 Quite High
Pressure And Volume Under Development 6 60.24 Quite High
Heart Rate Under Development 3 58.72 Quite High
Vomiting 9 58.08 Quite High
Abdominal Pain 3 57.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For instance, while there is hallmark evidence for the importance of the endopeptidase Phex, whose inactivation in Hyp mice or human patients causes X-linked hypophosphatemic rickets, it is still largely unknown how Phex controls bone mineralization since a physiological substrate for its endopeptidase activity has not been identified yet.
Regulation (importance) of Phex associated with rickets
1) Confidence 0.26 Published 2010 Journal Calcif. Tissue Int. Section Abstract Doc Link 20204609 Disease Relevance 0.19 Pain Relevance 0.12
Although there have been no controlled clinical trials of PEX in MG, several series demonstrate significantly improved strength in most patients with severe MG undergoing PEX [61-63].
Neg (no) Regulation (controlled) of PEX associated with myasthenia gravis
2) Confidence 0.19 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC2211463 Disease Relevance 1.01 Pain Relevance 0.13
Progesterone-regulated cyclic modulation of membrane metalloendopeptidase (enkephalinase) in human endometrium.
Regulation (modulation) of metalloendopeptidase in endometrium
3) Confidence 0.17 Published 1991 Journal J. Biol. Chem. Section Title Doc Link 1744100 Disease Relevance 0.09 Pain Relevance 0.14
We synthesized modifications of these peptides to investigate the role of the HYP residues.
Spec (investigate) Regulation (role) of HYP
4) Confidence 0.07 Published 2008 Journal Blood Section Body Doc Link PMC2602586 Disease Relevance 0.19 Pain Relevance 0

General Comments

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