INT155889

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Context Info
Confidence 0.42
First Reported 2004
Last Reported 2011
Negated 2
Speculated 1
Reported most in Body
Documents 22
Total Number 22
Disease Relevance 9.79
Pain Relevance 2.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Nps) molecular_function (Nps)
Anatomy Link Frequency
neuronal 1
arms 1
heart 1
body 1
Nps (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 16 99.54 Very High Very High Very High
Opioid 6 99.52 Very High Very High Very High
amygdala 405 99.48 Very High Very High Very High
projection neuron 120 97.36 Very High Very High Very High
Inflammation 53 94.28 High High
Pain management 1 92.76 High High
imagery 599 92.08 High High
Enkephalin 7 87.64 High High
palliative 1 75.80 Quite High
Neuropeptide 21 75.00 Quite High
Disease Link Frequency Relevance Heat
Anxiety Disorder 193 100.00 Very High Very High Very High
Natriuresis 36 100.00 Very High Very High Very High
Toxicity 70 99.84 Very High Very High Very High
Myocardial Infarction 28 99.52 Very High Very High Very High
Stress 104 99.30 Very High Very High Very High
Cardiovascular Disease 92 99.28 Very High Very High Very High
Alzheimer's Dementia 15 98.68 Very High Very High Very High
Glioblastoma 16 98.20 Very High Very High Very High
Calcification 3 98.16 Very High Very High Very High
Cancer 315 97.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results revealed the involvement of NPS in rewarding activities of morphine, and demonstrated the interaction between NPS system and opioid system for the first time.
NPS Binding (interaction) of associated with opioid and morphine
1) Confidence 0.42 Published 2009 Journal Peptides Section Abstract Doc Link 18992779 Disease Relevance 0 Pain Relevance 1.07
In the present study, our REM data show NPs bound to the cell surface, and the TEM results indicate that NPs are taken up into neuronal network cells.
NPs Binding (bound) of in neuronal
2) Confidence 0.41 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2957913 Disease Relevance 0.08 Pain Relevance 0.03
Hence the anti-oxidative and anti-hyperglycemic effect of gold nanoparticles along with their protective effect over the organ damage during conditions of hyperglycemia induced oxidative stress may be attained through the inhibition of the stress signaling pathways or, due to the interaction of the AuNPs to the cystein-residues of the thioredoxin thereby preventing the inhibitor protein Txnip from binding to it during high glucose levels which is to be revealed yet.
AuNPs Binding (interaction) of associated with stress and hyperglycemia
3) Confidence 0.35 Published 2010 Journal J Nanobiotechnology Section Body Doc Link PMC2914719 Disease Relevance 0.52 Pain Relevance 0
Fourthly, recordings from isolated BLA slices showed a complete absence of NPS-effects on sIPSC activity.
NPS Neg (absence) Binding (absence) of associated with amygdala
4) Confidence 0.31 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2442874 Disease Relevance 0 Pain Relevance 0.39
Here, no significant effect of NPS treatment was observed on anxiety-like behavior or exploratory activity, as time on open arms (F2.37?
NPS Binding (time) of in arms associated with anxiety disorder
5) Confidence 0.31 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2442874 Disease Relevance 0.50 Pain Relevance 0.04
8) before addition of NPS to 9.5±1.2 Hz (n?
NPS Binding (addition) of
6) Confidence 0.31 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2442874 Disease Relevance 0 Pain Relevance 0.21
10) before addition of NPS to 10.1±1.4 Hz (n?
NPS Binding (addition) of
7) Confidence 0.31 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2442874 Disease Relevance 0 Pain Relevance 0.13
Comparison between the NPS and Non-NPS groups
NPS Binding (Comparison) of
8) Confidence 0.30 Published 2007 Journal BMC Nurs Section Body Doc Link PMC1821326 Disease Relevance 0.16 Pain Relevance 0
Individuals currently considered to be at moderate risk for CVD may stand to benefit the most from assessment with NPs.
NPs Binding (assessment) of associated with cardiovascular disease
9) Confidence 0.28 Published 2010 Journal Curr Cardiovasc Risk Rep Section Body Doc Link PMC2894089 Disease Relevance 0.68 Pain Relevance 0
Although NPs did not accurately discriminate individuals with left ventricular systolic dysfunction overall, performance among high-risk men (age ?
NPs Neg (not) Binding (individuals) of
10) Confidence 0.28 Published 2010 Journal Curr Cardiovasc Risk Rep Section Body Doc Link PMC2894089 Disease Relevance 0.79 Pain Relevance 0
Characterization of the AuNPs
AuNPs Binding (Characterization) of
11) Confidence 0.27 Published 2010 Journal J Nanobiotechnology Section Body Doc Link PMC2914719 Disease Relevance 0.27 Pain Relevance 0
Characterization of Au-NPs
NPs Binding (Characterization) of
12) Confidence 0.27 Published 2010 Journal J Nanobiotechnology Section Body Doc Link PMC2914719 Disease Relevance 0.75 Pain Relevance 0.07
NPs also highlighted some of the program drawbacks.
NPs Binding (highlighted) of
13) Confidence 0.23 Published 2007 Journal BMC Health Serv Res Section Body Doc Link PMC2020484 Disease Relevance 0.18 Pain Relevance 0.17
They concluded that the toxicity of DOX bound to NPs was similar, or even lower, than that of free DOX.
NPs Binding (bound) of associated with toxicity
14) Confidence 0.22 Published 2010 Journal Part Fibre Toxicol Section Body Doc Link PMC2847536 Disease Relevance 0.79 Pain Relevance 0.03
Other studies aimed at investigating the toxicological profile of doxorubicin bound to NPs employing different dose regimens correlates with the results of this study [146].
NPs Binding (bound) of
15) Confidence 0.19 Published 2010 Journal Part Fibre Toxicol Section Body Doc Link PMC2847536 Disease Relevance 0.72 Pain Relevance 0.03
Although, much of the work has been focused towards drug delivery with NPs, relatively few studies have focused on the interaction of NPs and their hosts in terms of biodistribution, organ accumulation, degradation and/or toxicology like possible damage of cellular structures or inflammatory foreign body effects.
NPs Binding (interaction) of in body associated with inflammation and foreign bodies
16) Confidence 0.19 Published 2010 Journal Part Fibre Toxicol Section Body Doc Link PMC2847536 Disease Relevance 0.67 Pain Relevance 0.11
Further studies are needed to investigate whether these metal chelators conjugated to NPs can play a role in solubilizing amyloid- [beta] deposits in Alzheimer disease.
NPs Binding (conjugated) of associated with alzheimer's dementia
17) Confidence 0.15 Published 2010 Journal Part Fibre Toxicol Section Body Doc Link PMC2847536 Disease Relevance 0.61 Pain Relevance 0
Gelperina et al. [139] studied the toxicity of DOX bound to polysorbate 80-coated PBCA NPs in healthy rats, and rats with intracranial glioblastoma.
NPs Binding (bound) of associated with toxicity and glioblastoma
18) Confidence 0.14 Published 2010 Journal Part Fibre Toxicol Section Body Doc Link PMC2847536 Disease Relevance 0.75 Pain Relevance 0.03
David Cheresh's group at the Scripps Research Institute showed that NPs coupled to an integrin ?
NPs Binding (coupled) of
19) Confidence 0.12 Published 2004 Journal J Transl Med Section Body Doc Link PMC455695 Disease Relevance 0.19 Pain Relevance 0.08
Thus, the relationship between BNP, renal function, and the severity of heart failure is less clear, and the association between NPs levels and renal function remains complex.
NPs Spec (clear) Binding (association) of in heart associated with myocardial infarction
20) Confidence 0.07 Published 2011 Journal International Journal of Nephrology Section Body Doc Link PMC3017903 Disease Relevance 0.99 Pain Relevance 0

General Comments

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