INT155891

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Context Info
Confidence 0.27
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 0.17
Pain Relevance 3.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Casp3) intracellular (Casp3) cytoplasm (Casp3)
cytosol (Casp3) peptidase activity (Casp3) extracellular region (Nps)
Nps (Mus musculus)
Casp3 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 33 100.00 Very High Very High Very High
Opioid 3 87.04 High High
Neuropeptide 12 75.00 Quite High
Substantia nigra 3 67.84 Quite High
Ventral tegmentum 3 66.60 Quite High
amygdala 3 65.48 Quite High
Disease Link Frequency Relevance Heat
Anxiety Disorder 3 61.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results showed that NPS (0.3-10 nmol) alone neither induced place preference nor aversion, however, NPS (1 and 3 nmol) blocked the acquisition of CPP induced by 3 nmol morphine, and acquisition of 6 nmol morphine-induced CPP was also reduced by NPS (6 and 10 nmol).
NPS Negative_regulation (reduced) of Positive_regulation (induced) of CPP associated with morphine
1) Confidence 0.27 Published 2009 Journal Peptides Section Abstract Doc Link 18992779 Disease Relevance 0.06 Pain Relevance 1.16
Moreover, the expression of CPP induced by 6 nmol morphine was also inhibited by NPS (0.1, 1 and 10 nmol).
NPS Negative_regulation (inhibited) of Positive_regulation (induced) of CPP associated with morphine
2) Confidence 0.27 Published 2009 Journal Peptides Section Abstract Doc Link 18992779 Disease Relevance 0.05 Pain Relevance 1.15
Our results showed that NPS (0.3-10 nmol) alone neither induced place preference nor aversion, however, NPS (1 and 3 nmol) blocked the acquisition of CPP induced by 3 nmol morphine, and acquisition of 6 nmol morphine-induced CPP was also reduced by NPS (6 and 10 nmol).
NPS Negative_regulation (blocked) of Positive_regulation (induced) of CPP associated with morphine
3) Confidence 0.23 Published 2009 Journal Peptides Section Abstract Doc Link 18992779 Disease Relevance 0.06 Pain Relevance 1.17

General Comments

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