INT155915

Context Info Confidence 0.48 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0 Pain Relevance 0

nucleoplasm (PARP1, PARP1, NFKB1) nucleolus (PARP1, PARP1, NFKB1) nucleus (PARP1, PARP1, NFKB1) nuclear envelope (PARP1, PARP1) transferase activity, transferring glycosyl groups (PARP1, PARP1) intracellular (PARP1, PARP1)

Anatomy Link Frequency MNCs 4 PARP1 (Homo sapiens) PARP1 (Homo sapiens) NFKB1 (Homo sapiens)

Pain Link Frequency Relevance Heat Angina 8 50.00 cytokine 4 5.00 Inflammation 2 5.00

Disease Link Frequency Relevance Heat Cv General 3 Under Development 8 50.00 INFLAMMATION 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Overexpressed PARP-1 promotes PARP-1/NF-kappaB/DNA complex formation, thereby enhancing the expression of TNF-alpha and IL-6 in circulating MNCs of UA patients.

PARP Positive_regulation (enhancing) of PARP Binding (formation) of NF-kappaB in MNCs

1) Confidence 0.48 Published 2008 Journal Arch. Med. Res. Section Body Doc Link 18996291 Disease Relevance 0 Pain Relevance 0

Overexpressed PARP-1 promotes PARP-1/NF-kappaB/DNA complex formation, thereby enhancing the expression of TNF-alpha and IL-6 in circulating MNCs of UA patients.

PARP Positive_regulation (promotes) of PARP Binding (formation) of NF-kappaB in MNCs

2) Confidence 0.48 Published 2008 Journal Arch. Med. Res. Section Body Doc Link 18996291 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.