INT155921

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.49
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.44
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (PARP1) nuclear envelope (PARP1) aging (IL6)
transferase activity, transferring glycosyl groups (PARP1) intracellular (PARP1) DNA binding (PARP1)
Anatomy Link Frequency
MNCs 4
PARP1 (Homo sapiens)
IL6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 8 98.84 Very High Very High Very High
cytokine 4 92.28 High High
Inflammation 2 91.88 High High
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 8 98.84 Very High Very High Very High
INFLAMMATION 2 91.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overexpressed PARP-1 promotes PARP-1/NF-kappaB/DNA complex formation, thereby enhancing the expression of TNF-alpha and IL-6 in circulating MNCs of UA patients.


PARP Positive_regulation (enhancing) of Gene_expression (expression) of IL-6 in MNCs
1) Confidence 0.49 Published 2008 Journal Arch. Med. Res. Section Body Doc Link 18996291 Disease Relevance 0 Pain Relevance 0
This study aims to investigate the relationship of PARP-1 in circulating mononuclear cells (MNCs) and plasma TNF-alpha and IL-6 in UA patients and to elucidate the mechanism that PARP-1 promotes TNF-alpha and IL-6 expression via NF-kappaB pathway.
PARP Positive_regulation (promotes) of Gene_expression (expression) of IL-6 in MNCs associated with angina
2) Confidence 0.33 Published 2008 Journal Arch. Med. Res. Section Abstract Doc Link 18996291 Disease Relevance 0.44 Pain Relevance 0.48

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox