INT155923

Context Info Confidence 0.36 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.07 Pain Relevance 0

intracellular (PARP1, TNF) nucleoplasm (PARP1) nuclear envelope (PARP1) transferase activity, transferring glycosyl groups (PARP1) extracellular matrix organization (TNF) DNA binding (PARP1)

Anatomy Link Frequency MNCs 3 PARP1 (Homo sapiens) TNF (Homo sapiens)

Pain Link Frequency Relevance Heat Angina 4 50.00 cytokine 2 5.00 Inflammation 1 5.00

Disease Link Frequency Relevance Heat Cv General 3 Under Development 4 65.48 INFLAMMATION 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In cultured MNCs from healthy subjects, inhibition of PARP-1 prevented lipopolysaccharide-induced increase in DNA binding activity of NF-kappaB and the expression of TNF-alpha and IL-6.

Negative_regulation (inhibition) of PARP in MNCs Negative_regulation (prevented) of Gene_expression (expression) of TNF-alpha in MNCs

1) Confidence 0.36 Published 2008 Journal Arch. Med. Res. Section Body Doc Link 18996291 Disease Relevance 0.07 Pain Relevance 0

General Comments

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