INT155923

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Context Info
Confidence 0.36
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.07
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (PARP1, TNF) nucleoplasm (PARP1) nuclear envelope (PARP1)
transferase activity, transferring glycosyl groups (PARP1) extracellular matrix organization (TNF) DNA binding (PARP1)
Anatomy Link Frequency
MNCs 3
PARP1 (Homo sapiens)
TNF (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 4 50.00 Quite Low
cytokine 2 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 4 65.48 Quite High
INFLAMMATION 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In cultured MNCs from healthy subjects, inhibition of PARP-1 prevented lipopolysaccharide-induced increase in DNA binding activity of NF-kappaB and the expression of TNF-alpha and IL-6.
Negative_regulation (inhibition) of PARP in MNCs Negative_regulation (prevented) of Gene_expression (expression) of TNF-alpha in MNCs
1) Confidence 0.36 Published 2008 Journal Arch. Med. Res. Section Body Doc Link 18996291 Disease Relevance 0.07 Pain Relevance 0

General Comments

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