INT155924

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Context Info
Confidence 0.34
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 0.23
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (PARP1, NFKB1) nucleolus (PARP1, NFKB1) nucleus (PARP1, NFKB1)
mitochondrion (NFKB1) nuclear envelope (PARP1) transferase activity, transferring glycosyl groups (PARP1)
Anatomy Link Frequency
MNCs 4
PARP1 (Homo sapiens)
NFKB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 20 50.00 Quite Low
cytokine 10 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 20 85.96 High High
INFLAMMATION 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Circulating MNCs were analyzed for PARP activity, PARP-1 expression and NF-kappaB DNA binding activity.
PARP Binding (binding) of NF-kappaB in MNCs
1) Confidence 0.34 Published 2008 Journal Arch. Med. Res. Section Body Doc Link 18996291 Disease Relevance 0.09 Pain Relevance 0
Circulating MNCs were analyzed for PARP activity, PARP-1 expression and NF-kappaB DNA binding activity.
PARP Binding (binding) of NF-kappaB in MNCs
2) Confidence 0.34 Published 2008 Journal Arch. Med. Res. Section Body Doc Link 18996291 Disease Relevance 0.09 Pain Relevance 0
Overexpressed PARP-1 promotes PARP-1/NF-kappaB/DNA complex formation, thereby enhancing the expression of TNF-alpha and IL-6 in circulating MNCs of UA patients.


PARP Binding (formation) of NF-kappaB in MNCs
3) Confidence 0.32 Published 2008 Journal Arch. Med. Res. Section Body Doc Link 18996291 Disease Relevance 0 Pain Relevance 0
Overexpressed PARP-1 promotes PARP-1/NF-kappaB/DNA complex formation, thereby enhancing the expression of TNF-alpha and IL-6 in circulating MNCs of UA patients.


PARP Binding (formation) of NF-kappaB in MNCs
4) Confidence 0.32 Published 2008 Journal Arch. Med. Res. Section Body Doc Link 18996291 Disease Relevance 0 Pain Relevance 0
Supershift assay demonstrated that PARP-1 was a component of NF-kappaB/DNA complex.
PARP Binding (complex) of NF-kappaB
5) Confidence 0.32 Published 2008 Journal Arch. Med. Res. Section Body Doc Link 18996291 Disease Relevance 0.06 Pain Relevance 0

General Comments

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