INT155927

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Context Info
Confidence 0.49
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.32
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (PARP1) nuclear envelope (PARP1) transferase activity, transferring glycosyl groups (PARP1)
intracellular (PARP1) DNA binding (PARP1) nucleolus (PARP1)
Anatomy Link Frequency
MNCs 2
PARP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 4 50.00 Quite Low
Inflammation 9 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 44 73.84 Quite High
Apoptosis 71 70.80 Quite High
Cv General 3 Under Development 4 55.08 Quite High
Cancer 125 52.08 Quite High
Death 10 5.00 Very Low Very Low Very Low
INFLAMMATION 7 5.00 Very Low Very Low Very Low
Repression 2 5.00 Very Low Very Low Very Low
Breast Cancer 2 5.00 Very Low Very Low Very Low
Shock 2 5.00 Very Low Very Low Very Low
Inflammatory Bowel Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Addition of recombinant human PARP-1 protein to nuclear extracts of MNCs significantly increased the DNA binding activity of NF-kappaB.
Positive_regulation (increased) of PARP-1 protein Binding (binding) of in MNCs
1) Confidence 0.49 Published 2008 Journal Arch. Med. Res. Section Body Doc Link 18996291 Disease Relevance 0.06 Pain Relevance 0
Membranes were blocked with 5% milk in TBS containing 0.1% Tween 20, and incubated with antibodies specific for caspase 8 (Abcam), caspase 9, PARP, Snail (Cell Signaling Technology), pGSK3?
Positive_regulation (incubated) of PARP Binding (specific) of
2) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908545 Disease Relevance 0.26 Pain Relevance 0

General Comments

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