INT155927

Context Info Confidence 0.49 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.32 Pain Relevance 0

nucleoplasm (PARP1) nuclear envelope (PARP1) transferase activity, transferring glycosyl groups (PARP1) intracellular (PARP1) DNA binding (PARP1) nucleolus (PARP1)

Anatomy Link Frequency MNCs 2 PARP1 (Homo sapiens)

Pain Link Frequency Relevance Heat Angina 4 50.00 Inflammation 9 5.00 cytokine 5 5.00 cINOD 1 5.00 antagonist 1 5.00

Disease Link Frequency Relevance Heat Colon Cancer 44 73.84 Apoptosis 71 70.80 Cv General 3 Under Development 4 55.08 Cancer 125 52.08 Death 10 5.00 INFLAMMATION 7 5.00 Repression 2 5.00 Breast Cancer 2 5.00 Shock 2 5.00 Inflammatory Bowel Disease 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Addition of recombinant human PARP-1 protein to nuclear extracts of MNCs significantly increased the DNA binding activity of NF-kappaB.

Positive_regulation (increased) of PARP-1 protein Binding (binding) of in MNCs

1) Confidence 0.49 Published 2008 Journal Arch. Med. Res. Section Body Doc Link 18996291 Disease Relevance 0.06 Pain Relevance 0

Membranes were blocked with 5% milk in TBS containing 0.1% Tween 20, and incubated with antibodies specific for caspase 8 (Abcam), caspase 9, PARP, Snail (Cell Signaling Technology), pGSK3?

Positive_regulation (incubated) of PARP Binding (specific) of

2) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908545 Disease Relevance 0.26 Pain Relevance 0

General Comments

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