INT155928

Context Info Confidence 0.68 First Reported 2007 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 13 Total Number 13 Disease Relevance 6.54 Pain Relevance 2.10

nucleoplasm (PARP1) nuclear envelope (PARP1) transferase activity, transferring glycosyl groups (PARP1) intracellular (PARP1) DNA binding (PARP1) nucleolus (PARP1)

Anatomy Link Frequency MNCs 10 cleavage 6 plasma 2 hepatocytes 2 PARP1 (Homo sapiens)

Pain Link Frequency Relevance Heat Osteoarthritis 64 100.00 qutenza 7 96.64 Angina 24 96.36 cytokine 22 95.04 rheumatoid arthritis 4 94.72 Inflammation 56 88.44 Inflammatory response 3 78.32 antagonist 5 74.16 metalloproteinase 3 69.08 Paracetamol 3 42.80

Disease Link Frequency Relevance Heat Osteoarthritis 71 100.00 Injury 15 99.96 Cancer 188 99.84 Breast Cancer 88 99.24 Cv General 3 Under Development 24 96.36 Colon Cancer 46 96.04 Apoptosis 133 96.00 Rheumatoid Arthritis 4 94.72 Advanced Or Metastatic Breast Cancer 62 92.92 Necrosis 3 89.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Overexpressed PARP-1 promotes PARP-1/NF-kappaB/DNA complex formation, thereby enhancing the expression of TNF-alpha and IL-6 in circulating MNCs of UA patients.

Positive_regulation (Overexpressed) of Gene_expression (Overexpressed) of PARP in MNCs

1) Confidence 0.68 Published 2008 Journal Arch. Med. Res. Section Body Doc Link 18996291 Disease Relevance 0 Pain Relevance 0

Activation and overexpression of PARP-1 in circulating mononuclear cells promote TNF-alpha and IL-6 expression in patients with unstable angina.

Positive_regulation (overexpression) of Gene_expression (overexpression) of PARP in mononuclear cells associated with angina

2) Confidence 0.68 Published 2008 Journal Arch. Med. Res. Section Title Doc Link 18996291 Disease Relevance 0.37 Pain Relevance 0.50

CONCLUSIONS: Activation and overexpression of PARP-1 are demonstrated in circulating MNCs of UA patients.

Positive_regulation (overexpression) of Gene_expression (overexpression) of PARP in MNCs

3) Confidence 0.68 Published 2008 Journal Arch. Med. Res. Section Body Doc Link 18996291 Disease Relevance 0 Pain Relevance 0

Activation and overexpression of PARP-1 in circulating mononuclear cells promote TNF-alpha and IL-6 expression in patients with unstable angina.

Positive_regulation (Activation) of Gene_expression (overexpression) of PARP in mononuclear cells associated with angina

4) Confidence 0.49 Published 2008 Journal Arch. Med. Res. Section Title Doc Link 18996291 Disease Relevance 0.37 Pain Relevance 0.50

CONCLUSIONS: Activation and overexpression of PARP-1 are demonstrated in circulating MNCs of UA patients.

Positive_regulation (overexpression) of Gene_expression (overexpression) of PARP in MNCs

5) Confidence 0.49 Published 2008 Journal Arch. Med. Res. Section Body Doc Link 18996291 Disease Relevance 0 Pain Relevance 0

RESULTS: PARP activity and PARP-1 expression in circulating MNCs were increased and positively correlated with plasma TNF-alpha and IL-6, respectively, in UA patients.

Positive_regulation (increased) of Gene_expression (expression) of PARP in plasma

6) Confidence 0.46 Published 2008 Journal Arch. Med. Res. Section Body Doc Link 18996291 Disease Relevance 0.08 Pain Relevance 0

Notably, capsaicin blocked breast cancer cell migration in vitro and decreased by 50% the size of MDA-MB231 breast cancer tumors growing orthotopically in immunodeficient mice without noticeable drug side effects. in vivo activation of ERK was clearly decreased, as well as expression of HER-2 and cyclin D1, whereas caspase activity and PARP cleavage products were increased in tumors of drug-treated mice.

Positive_regulation (increased) of Gene_expression (products) of PARP in cleavage associated with qutenza, cancer and breast cancer

7) Confidence 0.28 Published 2010 Journal Oncogene Section Abstract Doc Link 19855437 Disease Relevance 0.90 Pain Relevance 0.47

Moreover, our data are consistent with prior observations suggesting that RHOB, a member of the Rho GTP-binding protein, is overexpressed in OA [17], [18] and the positive association in the expression levels of RHOB and PARP-1 [19].

Positive_regulation (overexpressed) of Gene_expression (levels) of PARP-1 associated with osteoarthritis

8) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012157 Disease Relevance 1.11 Pain Relevance 0.48

M) that increased PARP cleavage (Figure 5a).

Positive_regulation (increased) of Gene_expression (cleavage) of PARP in cleavage

9) Confidence 0.18 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246173 Disease Relevance 0 Pain Relevance 0.04

In case of severe DNA injury, overactivation of PARP-1 depletes the cellular stores of NAD+, an essential cofactor in the glycolytic pathway, the tricarboxylic acid cycle, and the mitochondrial electron transport chain.

Positive_regulation (overactivation) of Gene_expression (overactivation) of PARP associated with injury

10) Confidence 0.17 Published 2008 Journal Interdisciplinary Toxicology Section Body Doc Link PMC2993477 Disease Relevance 0.98 Pain Relevance 0.11

Gene expression profiling performed primarily on breast cancer samples from 50 patients showed that PARP-1 expression was significantly upregulated (P <0.0001).

Positive_regulation (upregulated) of Gene_expression (expression) of PARP associated with breast cancer

11) Confidence 0.15 Published 2010 Journal Breast Cancer Res Section Body Doc Link PMC2972555 Disease Relevance 0.98 Pain Relevance 0

Like THP1 macrophages, normal peripheral blood monocytes restored the MMP and prevented activation of caspase 8 and cleavage of PARP in TRAIL-treated tumor cells (data not shown, Figure S2), which is consistent with the ability of colon cancer cells to induce IL-1?

Positive_regulation (activation) of Gene_expression (cleavage) of PARP in cleavage associated with cancer and colon cancer

12) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908545 Disease Relevance 1.08 Pain Relevance 0

Prior treatment of natansnin profoundly decreased the increased expression of caspase- 3, PARP cleavage and translocation of cytochrome C from mitochondria to cytosol indicating that natansnin decreases the apoptosis in hepatocytes.

Positive_regulation (increased) of Gene_expression (expression) of PARP in hepatocytes associated with apoptosis

13) Confidence 0.03 Published 2010 Journal BMC Pharmacol Section Body Doc Link PMC2967507 Disease Relevance 0.67 Pain Relevance 0

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