INT155928

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Context Info
Confidence 0.68
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 6.54
Pain Relevance 2.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (PARP1) nuclear envelope (PARP1) transferase activity, transferring glycosyl groups (PARP1)
intracellular (PARP1) DNA binding (PARP1) nucleolus (PARP1)
Anatomy Link Frequency
MNCs 10
cleavage 6
plasma 2
hepatocytes 2
PARP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 64 100.00 Very High Very High Very High
qutenza 7 96.64 Very High Very High Very High
Angina 24 96.36 Very High Very High Very High
cytokine 22 95.04 Very High Very High Very High
rheumatoid arthritis 4 94.72 High High
Inflammation 56 88.44 High High
Inflammatory response 3 78.32 Quite High
antagonist 5 74.16 Quite High
metalloproteinase 3 69.08 Quite High
Paracetamol 3 42.80 Quite Low
Disease Link Frequency Relevance Heat
Osteoarthritis 71 100.00 Very High Very High Very High
Injury 15 99.96 Very High Very High Very High
Cancer 188 99.84 Very High Very High Very High
Breast Cancer 88 99.24 Very High Very High Very High
Cv General 3 Under Development 24 96.36 Very High Very High Very High
Colon Cancer 46 96.04 Very High Very High Very High
Apoptosis 133 96.00 Very High Very High Very High
Rheumatoid Arthritis 4 94.72 High High
Advanced Or Metastatic Breast Cancer 62 92.92 High High
Necrosis 3 89.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overexpressed PARP-1 promotes PARP-1/NF-kappaB/DNA complex formation, thereby enhancing the expression of TNF-alpha and IL-6 in circulating MNCs of UA patients.


Positive_regulation (Overexpressed) of Gene_expression (Overexpressed) of PARP in MNCs
1) Confidence 0.68 Published 2008 Journal Arch. Med. Res. Section Body Doc Link 18996291 Disease Relevance 0 Pain Relevance 0
Activation and overexpression of PARP-1 in circulating mononuclear cells promote TNF-alpha and IL-6 expression in patients with unstable angina.
Positive_regulation (overexpression) of Gene_expression (overexpression) of PARP in mononuclear cells associated with angina
2) Confidence 0.68 Published 2008 Journal Arch. Med. Res. Section Title Doc Link 18996291 Disease Relevance 0.37 Pain Relevance 0.50
CONCLUSIONS: Activation and overexpression of PARP-1 are demonstrated in circulating MNCs of UA patients.
Positive_regulation (overexpression) of Gene_expression (overexpression) of PARP in MNCs
3) Confidence 0.68 Published 2008 Journal Arch. Med. Res. Section Body Doc Link 18996291 Disease Relevance 0 Pain Relevance 0
Activation and overexpression of PARP-1 in circulating mononuclear cells promote TNF-alpha and IL-6 expression in patients with unstable angina.
Positive_regulation (Activation) of Gene_expression (overexpression) of PARP in mononuclear cells associated with angina
4) Confidence 0.49 Published 2008 Journal Arch. Med. Res. Section Title Doc Link 18996291 Disease Relevance 0.37 Pain Relevance 0.50
CONCLUSIONS: Activation and overexpression of PARP-1 are demonstrated in circulating MNCs of UA patients.
Positive_regulation (overexpression) of Gene_expression (overexpression) of PARP in MNCs
5) Confidence 0.49 Published 2008 Journal Arch. Med. Res. Section Body Doc Link 18996291 Disease Relevance 0 Pain Relevance 0
RESULTS: PARP activity and PARP-1 expression in circulating MNCs were increased and positively correlated with plasma TNF-alpha and IL-6, respectively, in UA patients.
Positive_regulation (increased) of Gene_expression (expression) of PARP in plasma
6) Confidence 0.46 Published 2008 Journal Arch. Med. Res. Section Body Doc Link 18996291 Disease Relevance 0.08 Pain Relevance 0
Notably, capsaicin blocked breast cancer cell migration in vitro and decreased by 50% the size of MDA-MB231 breast cancer tumors growing orthotopically in immunodeficient mice without noticeable drug side effects. in vivo activation of ERK was clearly decreased, as well as expression of HER-2 and cyclin D1, whereas caspase activity and PARP cleavage products were increased in tumors of drug-treated mice.
Positive_regulation (increased) of Gene_expression (products) of PARP in cleavage associated with qutenza, cancer and breast cancer
7) Confidence 0.28 Published 2010 Journal Oncogene Section Abstract Doc Link 19855437 Disease Relevance 0.90 Pain Relevance 0.47
Moreover, our data are consistent with prior observations suggesting that RHOB, a member of the Rho GTP-binding protein, is overexpressed in OA [17], [18] and the positive association in the expression levels of RHOB and PARP-1 [19].
Positive_regulation (overexpressed) of Gene_expression (levels) of PARP-1 associated with osteoarthritis
8) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012157 Disease Relevance 1.11 Pain Relevance 0.48
M) that increased PARP cleavage (Figure 5a).
Positive_regulation (increased) of Gene_expression (cleavage) of PARP in cleavage
9) Confidence 0.18 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246173 Disease Relevance 0 Pain Relevance 0.04
In case of severe DNA injury, overactivation of PARP-1 depletes the cellular stores of NAD+, an essential cofactor in the glycolytic pathway, the tricarboxylic acid cycle, and the mitochondrial electron transport chain.
Positive_regulation (overactivation) of Gene_expression (overactivation) of PARP associated with injury
10) Confidence 0.17 Published 2008 Journal Interdisciplinary Toxicology Section Body Doc Link PMC2993477 Disease Relevance 0.98 Pain Relevance 0.11
Gene expression profiling performed primarily on breast cancer samples from 50 patients showed that PARP-1 expression was significantly upregulated (P <0.0001).
Positive_regulation (upregulated) of Gene_expression (expression) of PARP associated with breast cancer
11) Confidence 0.15 Published 2010 Journal Breast Cancer Res Section Body Doc Link PMC2972555 Disease Relevance 0.98 Pain Relevance 0
Like THP1 macrophages, normal peripheral blood monocytes restored the MMP and prevented activation of caspase 8 and cleavage of PARP in TRAIL-treated tumor cells (data not shown, Figure S2), which is consistent with the ability of colon cancer cells to induce IL-1?
Positive_regulation (activation) of Gene_expression (cleavage) of PARP in cleavage associated with cancer and colon cancer
12) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908545 Disease Relevance 1.08 Pain Relevance 0
Prior treatment of natansnin profoundly decreased the increased expression of caspase- 3, PARP cleavage and translocation of cytochrome C from mitochondria to cytosol indicating that natansnin decreases the apoptosis in hepatocytes.
Positive_regulation (increased) of Gene_expression (expression) of PARP in hepatocytes associated with apoptosis
13) Confidence 0.03 Published 2010 Journal BMC Pharmacol Section Body Doc Link PMC2967507 Disease Relevance 0.67 Pain Relevance 0

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