INT155944

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Context Info
Confidence 0.66
First Reported 2005
Last Reported 2011
Negated 3
Speculated 2
Reported most in Body
Documents 66
Total Number 70
Disease Relevance 24.37
Pain Relevance 9.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Foxp3) intracellular (Foxp3) embryo development (Foxp3)
DNA binding (Foxp3) cytoplasm (Foxp3)
Anatomy Link Frequency
T cells 25
natural Tregs 3
thymus 2
optic nerve 2
skin 2
Foxp3 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 857 99.98 Very High Very High Very High
Infliximab 27 99.76 Very High Very High Very High
cytokine 942 99.00 Very High Very High Very High
Inflammation 787 97.76 Very High Very High Very High
Neuritis 20 96.92 Very High Very High Very High
Angina 3 96.72 Very High Very High Very High
tolerance 352 95.32 Very High Very High Very High
Multiple sclerosis 763 94.24 High High
Arthritis 503 93.72 High High
Inflammatory response 68 93.72 High High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 857 99.98 Very High Very High Very High
Immunization 234 99.52 Very High Very High Very High
Ocular Injury 29 98.66 Very High Very High Very High
Lymphoproliferative Disease 18 98.44 Very High Very High Very High
INFLAMMATION 775 97.76 Very High Very High Very High
Autoimmune Disease 558 97.68 Very High Very High Very High
Hypersensitivity 186 97.24 Very High Very High Very High
Cancer 448 97.20 Very High Very High Very High
Optic Neuritis 15 97.16 Very High Very High Very High
Cv General 3 Under Development 5 96.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Changes in the Foxp3 expression of LNCs from KP-phototreated skin were also examined by real-time PCR.
Gene_expression (expression) of Foxp3 in skin
1) Confidence 0.66 Published 2009 Journal J. Dermatol. Sci. Section Body Doc Link 19157794 Disease Relevance 0.08 Pain Relevance 0
Decreased expression of Foxp3 mRNA and Treg in the optic nerve may play a key role in the development of optic neuritis.
Gene_expression (expression) of Foxp3 mRNA in optic associated with optic neuritis and neuritis
2) Confidence 0.66 Published 2010 Journal Int. J. Mol. Med. Section Abstract Doc Link 20428790 Disease Relevance 0.79 Pain Relevance 0.42
Protein analysis was done by enzyme-linked immunosorbent assay, quantitative real-time polymerase chain reaction for measuring the gene expression of IL-17, IFN-gamma, IL-4 and Foxp3.
Gene_expression (expression) of Foxp3
3) Confidence 0.66 Published 2010 Journal Int. J. Mol. Med. Section Abstract Doc Link 20428790 Disease Relevance 0.79 Pain Relevance 0.22
The VDR signal on the CD4+ T cells inhibits the expression of IL-17, IL-2, Foxp3, and CCR6 but enhances the expression of IL-10.
Gene_expression (expression) of Foxp3 in T cells
4) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944871 Disease Relevance 0.38 Pain Relevance 0.09
inhibited the expression of Foxp3 (Figure 2).
Gene_expression (expression) of Foxp3
5) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944871 Disease Relevance 0.51 Pain Relevance 0.09
To assess the expression of IL-17 and Foxp3, mRNA was extracted using TRIzol (Invitrogen, Camarillo, CA) according to the manufacturer's instructions and then reverse transcribed into cDNA.
Gene_expression (expression) of Foxp3
6) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944871 Disease Relevance 0.06 Pain Relevance 0
This result suggests that a penetrating ocular injury at an early stage after an AC injection of OVA does not alter the expression of CD4+CD25+Foxp3+T cells and thereby does not result in the induction of ACAID.
Gene_expression (expression) of Foxp3 in T cells associated with ocular injury
7) Confidence 0.64 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2255028 Disease Relevance 0.60 Pain Relevance 0.03
Recent studies reported that one population of CD8+Tregs was associated with Foxp3 expression [41-43], we further examined the expression of Foxp3 by CD8+CD94+T cells.
Gene_expression (expression) of Foxp3 in T cells
8) Confidence 0.59 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0 Pain Relevance 0.04
Recent studies reported that one population of CD8+Tregs was associated with Foxp3 expression [41-43], we further examined the expression of Foxp3 by CD8+CD94+T cells.
Spec (examined) Gene_expression (expression) of Foxp3 in T cells
9) Confidence 0.59 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0 Pain Relevance 0.04
As shown in Figure 3, the expression of intracellular granzyme B, perforin and Foxp3 in fresh CD8+CD94+T cells was minimal(~0.04%, ~0.01% and ~0.01%) in ACAID mice, immunized mice, PBS-AC-injected mice and naïve mice.
Gene_expression (expression) of Foxp3 in T cells
10) Confidence 0.59 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0 Pain Relevance 0
CD8+CD94+T cells were characterized by minimal expression of perforin, granzyme B and Foxp3.
Gene_expression (expression) of Foxp3 in T cells
11) Confidence 0.59 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0.07 Pain Relevance 0
To characterize CD8+CD94+T cells, we examined the intracellular expression of granzyme B, perforin and Foxp3.
Spec (examined) Gene_expression (expression) of Foxp3 in T cells
12) Confidence 0.59 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0 Pain Relevance 0
Expression of perforin, granzyme B and Foxp3 in CD8+CD94+T cells was minimal
Gene_expression (Expression) of Foxp3 in T cells
13) Confidence 0.59 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0 Pain Relevance 0
CD4(+)CD25(+)Foxp3(+) regulatory T (Treg) cells, produced in the thymus or periphery as a functionally mature T cell subpopulation, play pivotal roles in maintenance of self-tolerance and negative regulation of immune responses.
Gene_expression (produced) of Foxp3 in mature T cell associated with tolerance
14) Confidence 0.55 Published 2009 Journal Transpl. Immunol. Section Abstract Doc Link 19146957 Disease Relevance 0.24 Pain Relevance 0.35
The objective of this study was to detect interleukin-17 (IL-17), interferon-gamma (IFN-gamma), interleukin-4 (IL-4) and forkhead/winged helix transcription factor p3 (Foxp3) protein and gene expression of the optic nerve and to further explore the role of T helper cell subsets such as Th1, Th2, Th17 and Treg in the pathogenesis of optic neuritis in experimental autoimmune encephalomyelitis (EAE).
Gene_expression (expression) of Foxp3 in optic nerve associated with multiple sclerosis, optic neuritis and neuritis
15) Confidence 0.51 Published 2010 Journal Int. J. Mol. Med. Section Abstract Doc Link 20428790 Disease Relevance 0.51 Pain Relevance 0.09
An in vitro culture of naïve KJ1-26+CD4+ T cells with 1,25(OH)2D3 in the presence of OVA peptide and APCs significantly inhibited the generation of both Foxp3 and IL-17-secreting cells (Figure 3A).
Gene_expression (generation) of Foxp3 in T cells
16) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944871 Disease Relevance 0.06 Pain Relevance 0
We also confirmed that 1,25(OH)2D3 inhibited Foxp3 and IL-17 expression in a dose-dependent manner (data not shown).
Gene_expression (expression) of Foxp3
17) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944871 Disease Relevance 0 Pain Relevance 0
Here we show that IL-4 blocked the generation of TGF-beta-induced Foxp3(+) T(reg) cells and instead induced a population of T helper cells that produced IL-9 and IL-10.
Gene_expression (generation) of Foxp3
18) Confidence 0.49 Published 2008 Journal Nat. Immunol. Section Abstract Doc Link 18997793 Disease Relevance 0.15 Pain Relevance 0.10
They can be identified by high levels of FOXP3 and IL-2R?
Gene_expression (levels) of FOXP3
19) Confidence 0.48 Published 2010 Journal Diabetologia Section Body Doc Link PMC2910887 Disease Relevance 0.22 Pain Relevance 0.18
Intracellular co-staining for FOXP3 showed significant IFN?
Gene_expression (showed) of FOXP3
20) Confidence 0.48 Published 2010 Journal Diabetologia Section Body Doc Link PMC2910887 Disease Relevance 0.36 Pain Relevance 0.08

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