INT15597

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Context Info
Confidence 0.48
First Reported 1991
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 20
Total Number 21
Disease Relevance 6.04
Pain Relevance 11.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Jun) aging (Jun) nucleus (Jun)
DNA binding (Jun) transcription factor binding (Jun)
Anatomy Link Frequency
medulla 7
brainstem 4
neurons 4
blood 3
lateral areas 3
Jun (Rattus norvegicus)
Pain Link Frequency Relevance Heat
isoflurane 5 100.00 Very High Very High Very High
Clonidine 42 99.98 Very High Very High Very High
Rostral ventrolateral medulla 53 99.84 Very High Very High Very High
ketamine 14 99.84 Very High Very High Very High
agonist 21 99.76 Very High Very High Very High
medulla 29 99.44 Very High Very High Very High
qutenza 7 99.20 Very High Very High Very High
Snapping jaw 4 97.68 Very High Very High Very High
c fibre 20 97.04 Very High Very High Very High
Glutamate 14 94.32 High High
Disease Link Frequency Relevance Heat
Hypotension 68 99.80 Very High Very High Very High
Temporomandibular Joint Syndrome 4 97.68 Very High Very High Very High
Hypertension 7 95.36 Very High Very High Very High
Death 11 95.08 Very High Very High Very High
Chromosome Aberrations 1 85.88 High High
Stress 1 84.48 Quite High
Nociception 3 80.96 Quite High
Injury 4 76.80 Quite High
Pheochromocytoma 2 58.68 Quite High
Repression 2 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, the expression of phospho-c-Jun was substantially reduced by ketamine (0.1, 1.0 mM) and propofol (0.5, 5.0 microM), respectively, as determined by Western blot assay.
Negative_regulation (reduced) of Gene_expression (expression) of phospho-c-Jun associated with ketamine
1) Confidence 0.48 Published 2008 Journal J Neurosurg Anesthesiol Section Abstract Doc Link 18362774 Disease Relevance 0.47 Pain Relevance 0.55
There was also a strong potentiation of FosB and a strong reduction in c-Jun expression.
Negative_regulation (reduction) of Gene_expression (expression) of c-Jun
2) Confidence 0.46 Published 2001 Journal Brain Res. Section Abstract Doc Link 11251193 Disease Relevance 0.06 Pain Relevance 0.56
These results suggest: (1) the c-jun containing neurons in the brainstem are involved in the centrally mediated hypotension elicited by centrally acting antihypertensive agents, and (2) the alpha2-adrenoceptor modulates c-jun gene expression in the NTS and rostral ventrolateral medulla implicated in centrally mediated hypotension, and (3) the imidazoline I1 receptor mediated inhibition of c-jun gene expression in the rostral ventrolateral medulla, but not in the NTS, contributes to the centrally mediated hypotension by the second generation drugs.
Negative_regulation (inhibition) of Gene_expression (expression) of c-jun in medulla associated with medulla, rostral ventrolateral medulla and hypotension
3) Confidence 0.41 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15910806 Disease Relevance 0.48 Pain Relevance 0.44
Further, intra-rostral ventrolateral medulla rilmenidine (40 nmol) reduced c-Jun protein expression in rostral ventrolateral medulla and blood pressure and both responses were antagonized by selective imidazoline I1 receptor (efaroxan, 4 nmol), but not alpha2-adrenoceptor (SK&F 86466, 10 nmol) blockade.
Negative_regulation (reduced) of Gene_expression (expression) of c-Jun in blood associated with rostral ventrolateral medulla
4) Confidence 0.41 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15910806 Disease Relevance 0.56 Pain Relevance 0.53
In the present study, we investigated the relative contribution of the alpha2-adrenoceptor vs. the imidazoline I1 receptor to the reduction in c-jun gene expression in these two brainstem areas.
Negative_regulation (reduction) of Gene_expression (expression) of c-jun in brainstem associated with medulla
5) Confidence 0.41 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15910806 Disease Relevance 0.48 Pain Relevance 0.39
We show that pre- or post-treatment of capsaicin relative to MNNG administration up- or down-regulates (depending on the organ) c-jun expression in a consistent pattern in most organs.
Negative_regulation (down-regulates) of Gene_expression (expression) of c-jun associated with qutenza
6) Confidence 0.37 Published 1999 Journal Cancer Lett. Section Abstract Doc Link 10463771 Disease Relevance 0.26 Pain Relevance 0.53
In contrast, the expression of JUN D, which was present before stimulation in many spinal neurons, was increased after 4 h, reached its maximum after 8 h and thereafter remained elevated.
Negative_regulation (reached) of Gene_expression (expression) of JUN in neurons
7) Confidence 0.36 Published 1991 Journal Neurosci. Lett. Section Abstract Doc Link 1745403 Disease Relevance 0.07 Pain Relevance 0.18
Clonidine attenuated the increases in c-fos in the mNTS and cRVLM and c-jun gene expression in the mNTS and rRVLM caused by NP-evoked hypotension and also reduced the basal expression of c-jun mRNA in the mNTS and rRVLM.
Negative_regulation (reduced) of Gene_expression (expression) of c-jun mRNA associated with hypotension and clonidine
8) Confidence 0.35 Published 2000 Journal Brain Res. Section Abstract Doc Link 10677633 Disease Relevance 0.19 Pain Relevance 0.72
Clonidine diminishes c-jun gene expression in the cardiovascular sensitive areas of the rat brainstem.
Negative_regulation (diminishes) of Gene_expression (expression) of c-jun in brainstem associated with medulla and clonidine
9) Confidence 0.35 Published 2000 Journal Brain Res. Section Title Doc Link 10677633 Disease Relevance 0.13 Pain Relevance 0.69
In addition, the expression of phospho-c-Jun was substantially reduced by ketamine (0.1, 1.0 mM) and propofol (0.5, 5.0 microM), respectively, as determined by Western blot assay.
Negative_regulation (reduced) of Gene_expression (expression) of phospho-c-Jun associated with ketamine
10) Confidence 0.35 Published 2008 Journal J Neurosurg Anesthesiol Section Abstract Doc Link 18362774 Disease Relevance 0.47 Pain Relevance 0.55
In contrast, FosB was induced and continued to rise in all areas, whereas the basal expressions of c-Jun and Krox-24 were initially reduced but then returned during the subsequent 36 h.
Negative_regulation (reduced) of Gene_expression (expressions) of c-Jun
11) Confidence 0.34 Published 2001 Journal Brain Res. Section Abstract Doc Link 11251193 Disease Relevance 0.08 Pain Relevance 0.43
A weak C-fiber input caused by noxious mechanical stimulation of the skin of one hindpaw did not induce expression of c-Fos, FosB, Krox-20 or Krox-24; but it did reduce the basal expressions of c-Jun and JunD in both the medial and lateral areas.
Negative_regulation (reduce) of Gene_expression (expressions) of c-Jun in lateral areas associated with c fibre
12) Confidence 0.33 Published 2001 Journal Neuroscience Section Abstract Doc Link 11744254 Disease Relevance 0 Pain Relevance 0.74
Clonidine (0.5 microg), or alpha-methylnorepinephrine (alpha-MNE, 4 microg), a highly selective alpha2-adrenoceptor agonist, similarly reduced c-jun mRNA expression in the NTS and rostral ventrolateral medulla.
Negative_regulation (reduced) of Gene_expression (expression) of c-jun in medulla associated with rostral ventrolateral medulla, agonist and clonidine
13) Confidence 0.30 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15910806 Disease Relevance 0.50 Pain Relevance 0.56
In contrast, a similar hypotensive response (-37+/-3.5 mm Hg) caused by the selective imidazoline I1 receptor agonist rilmenidine (25 microg) was associated with reduction in c-jun mRNA expression in the rostral ventrolateral medulla, but not in the NTS.
Negative_regulation (reduction) of Gene_expression (expression) of c-jun in medulla associated with rostral ventrolateral medulla, hypotension and agonist
14) Confidence 0.30 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15910806 Disease Relevance 0.52 Pain Relevance 0.61
Clonidine (a mixed alpha2-adrenoceptor and imidazoline I1 receptor agonist)-evoked hypotension was associated with dissimilar reductions in c-jun gene expression in the rostral ventrolateral medulla (RVLM) and the nucleus tractus solitarius (NTS) in normotensive rats.
Negative_regulation (reductions) of Gene_expression (expression) of c-jun in nucleus associated with rostral ventrolateral medulla, hypotension, agonist and clonidine
15) Confidence 0.30 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15910806 Disease Relevance 0.37 Pain Relevance 0.27
These findings establish a causal link between clonidine inhibition of c-fos expression in brainstem and its hypotensive action, and provide the first evidence that clonidine attenuates the expression of the closely linked c-jun gene in neurons implicated in centrally mediated hypotension.
Negative_regulation (attenuates) of Gene_expression (expression) of c-jun in neurons associated with medulla, hypotension and clonidine
16) Confidence 0.26 Published 2000 Journal Brain Res. Section Abstract Doc Link 10677633 Disease Relevance 0.29 Pain Relevance 0.70
Clonidine attenuated the increases in c-fos in the mNTS and cRVLM and c-jun gene expression in the mNTS and rRVLM caused by NP-evoked hypotension and also reduced the basal expression of c-jun mRNA in the mNTS and rRVLM.
Negative_regulation (attenuated) of Gene_expression (expression) of c-jun associated with hypotension and clonidine
17) Confidence 0.26 Published 2000 Journal Brain Res. Section Abstract Doc Link 10677633 Disease Relevance 0.18 Pain Relevance 0.72
Immunohistochemical methodology was employed to evaluate the expression levels of pc-Jun, c-Fos, JNK2, p-JNK, p-ERK and Runx2 due to alteration in functional load.
Negative_regulation (evaluate) of Gene_expression (expression) of pc-Jun
18) Confidence 0.26 Published 2005 Journal Histochem. Cell Biol. Section Abstract Doc Link 16041628 Disease Relevance 0.37 Pain Relevance 0.37
Further, intra-rostral ventrolateral medulla rilmenidine (40 nmol) reduced c-Jun protein expression in rostral ventrolateral medulla and blood pressure and both responses were antagonized by selective imidazoline I1 receptor (efaroxan, 4 nmol), but not alpha2-adrenoceptor (SK&F 86466, 10 nmol) blockade.
Negative_regulation (reduced) of in medulla Gene_expression (expression) of c-Jun in blood associated with rostral ventrolateral medulla
19) Confidence 0.14 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15910806 Disease Relevance 0.56 Pain Relevance 0.53
A weak C-fiber input caused by noxious mechanical stimulation of the skin of one hindpaw did not induce expression of c-Fos, FosB, Krox-20 or Krox-24; but it did reduce the basal expressions of c-Jun and JunD in both the medial and lateral areas.
Negative_regulation (reduce) of in medial Gene_expression (expressions) of c-Jun in lateral areas associated with c fibre
20) Confidence 0.11 Published 2001 Journal Neuroscience Section Abstract Doc Link 11744254 Disease Relevance 0 Pain Relevance 0.74

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