INT155983

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Context Info
Confidence 0.58
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 2.60
Pain Relevance 3.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cyp11a1) oxidoreductase activity (Cyp11a1) lipid metabolic process (Cyp11a1)
Anatomy Link Frequency
liver 1
neurons 1
cleavage 1
Cyp11a1 (Mus musculus)
Pain Link Frequency Relevance Heat
Versed 32 99.52 Very High Very High Very High
Paracetamol 32 99.24 Very High Very High Very High
antagonist 12 91.36 High High
dexamethasone 2 87.56 High High
cva 1 85.84 High High
Regional anesthesia 2 85.68 High High
Antihistamine 1 70.44 Quite High
nMDA receptor 3 70.40 Quite High
Analgesic 1 66.64 Quite High
addiction 4 57.56 Quite High
Disease Link Frequency Relevance Heat
Injury 6 98.48 Very High Very High Very High
Cancer 28 98.04 Very High Very High Very High
Aging 63 96.80 Very High Very High Very High
Necrosis 3 85.92 High High
Hemorrhage 3 85.84 High High
Sprains And Strains 19 83.36 Quite High
Stress 8 82.16 Quite High
Body Weight 4 81.40 Quite High
Adrenal Cancer 4 80.16 Quite High
Nephrotoxicity 4 78.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PBR, P450scc, 3beta-HSD and StAR protein expression induced by MDZ was determined by Western blotting.
Gene_expression (expression) of P450scc associated with versed
1) Confidence 0.58 Published 2010 Journal Toxicol. Lett. Section Abstract Doc Link 19857560 Disease Relevance 0.17 Pain Relevance 0.61
In both cell types, MDZ-stimulated steroidogenesis in dose- and time-dependent manners, and induced the expression of PBR and StAR proteins, but had no effect on P450scc and 3beta-HSD expressions.
Gene_expression (expressions) of P450scc associated with versed
2) Confidence 0.58 Published 2010 Journal Toxicol. Lett. Section Abstract Doc Link 19857560 Disease Relevance 0.28 Pain Relevance 0.76
Moreover, APAP administration significantly increased MDA, protein carbonylation, GSSG level, intracellular ROS production and cytochrome P450 enzyme (CYPP450) activity.
Gene_expression (production) of cytochrome P450 enzyme associated with paracetamol
3) Confidence 0.43 Published 2010 Journal Toxicology Section Abstract Doc Link 20067817 Disease Relevance 0.45 Pain Relevance 0.90
Collectively, NF-kappaB was activated without any stimuli by the genetic disruption of IL-1ra, and suppressed cytochrome P450 enzyme expression, thereby reducing APAP-induced liver injury.
Gene_expression (expression) of cytochrome P450 enzyme in liver associated with paracetamol and injury
4) Confidence 0.18 Published 2009 Journal Lab. Invest. Section Abstract Doc Link 19002106 Disease Relevance 0.52 Pain Relevance 0.86
An interesting pattern is that, in many cases, P450 enzyme expression changes in long-lived mice and under CR were mirrored by expression differences in females relative to males.
Gene_expression (expression) of P450 enzyme
5) Confidence 0.08 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2094713 Disease Relevance 0.41 Pain Relevance 0
-hydroxylase, hydroxysteroid dehydrogenase, and several cholesterol side-chain cleavage enzymes.
Gene_expression (enzymes) of cholesterol side-chain cleavage in cleavage
6) Confidence 0.08 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2963160 Disease Relevance 0.60 Pain Relevance 0.11
However, the PREG synthase cytochrome P450 side-chain cleavage enzyme and hydroxysteroid sulfotransferase, which converts PREG to PREGS, are expressed in the brain [2], and these enzymes have been shown to colocalize in hippocampal neurons [38], suggesting local synthesis of PREGS.
Gene_expression (expressed) of PREG synthase cytochrome P450 side-chain in neurons
7) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2710005 Disease Relevance 0.17 Pain Relevance 0.14

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