INT155984

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Context Info
Confidence 0.24
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.92
Pain Relevance 2.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Il1a) extracellular space (Il1a) oxidoreductase activity (Cyp3a11)
extracellular region (Il1a) endoplasmic reticulum (Cyp3a11)
Anatomy Link Frequency
liver 4
Il1a (Mus musculus)
Cyp3a11 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 32 99.96 Very High Very High Very High
cva 2 96.88 Very High Very High Very High
antagonist 4 75.00 Quite High
Disease Link Frequency Relevance Heat
Injury 10 99.20 Very High Very High Very High
Hemorrhage 2 96.88 Very High Very High Very High
Necrosis 2 96.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, when given 12 h before APAP challenge, IL-1 alpha repressed the intrahepatic expression of CYP1A2, CYP2E1, and CYP3A11, eventually reducing APAP-induced liver injury, along with reduction in APAP adducts.
IL-1 alpha Negative_regulation (repressed) of Gene_expression (expression) of CYP3A11 in liver associated with paracetamol and injury
1) Confidence 0.24 Published 2009 Journal Lab. Invest. Section Abstract Doc Link 19002106 Disease Relevance 0.46 Pain Relevance 1.10
Finally, when given 12 h before APAP challenge, IL-1 alpha repressed the intrahepatic expression of CYP1A2, CYP2E1, and CYP3A11, eventually reducing APAP-induced liver injury, along with reduction in APAP adducts.
IL-1 alpha Negative_regulation (reducing) of Gene_expression (expression) of CYP3A11 in liver associated with paracetamol and injury
2) Confidence 0.24 Published 2009 Journal Lab. Invest. Section Abstract Doc Link 19002106 Disease Relevance 0.46 Pain Relevance 1.10

General Comments

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