INT155988

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Context Info
Confidence 0.24
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 2.19
Pain Relevance 6.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (ABAT)
Anatomy Link Frequency
neurons 2
synaptic vesicles 2
external 2
ABAT (Homo sapiens)
Pain Link Frequency Relevance Heat
gABA 128 100.00 Very High Very High Very High
Glutamate 17 100.00 Very High Very High Very High
Gabapentin 10 100.00 Very High Very High Very High
pregabalin 10 100.00 Very High Very High Very High
Dopamine 3 100.00 Very High Very High Very High
Cannabinoid 9 99.74 Very High Very High Very High
Cannabinoid receptor 42 99.70 Very High Very High Very High
anticonvulsant 6 97.44 Very High Very High Very High
Pain 8 97.40 Very High Very High Very High
Analgesic 4 96.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 3 99.16 Very High Very High Very High
Lifespan 81 98.56 Very High Very High Very High
Pain 14 97.40 Very High Very High Very High
Anxiety Disorder 6 96.20 Very High Very High Very High
Amblyopia 21 86.16 High High
Schizophrenia 106 84.24 Quite High
Aging 51 81.84 Quite High
Cannabis Dependence 24 50.44 Quite High
Injury 2 50.04 Quite High
Nociception 4 38.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of inhibitory neurons in the ACC can affect the excitability of these neurons by releasing GABA onto their postsynaptic receptors.
Regulation (affect) of Localization (releasing) of GABA in neurons associated with gaba
1) Confidence 0.24 Published 2005 Journal Mol Pain Section Body Doc Link PMC1183244 Disease Relevance 0.75 Pain Relevance 1.48
Both drugs had no effect on exocytotic (3)H-glutamate release and also failed to modulate the release of (3)H-GABA and (3)H-glutamate caused by reversed uptake in the absence of external Ca(2+).
Neg (failed) Regulation (modulate) of Localization (release) of GABA in external associated with gaba and glutamate
2) Confidence 0.17 Published 2009 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 19002437 Disease Relevance 0.06 Pain Relevance 1.46
Effects of gabapentin and pregabalin on K+-evoked 3H-GABA and 3H-glutamate release from human neocortical synaptosomes.
Regulation (Effects) of Localization (release) of GABA associated with pregabalin, glutamate, gaba and gabapentin
3) Confidence 0.17 Published 2009 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Title Doc Link 19002437 Disease Relevance 0.10 Pain Relevance 1.45
On the pre-synaptic side these include: the two isoforms of the GABA synthesizing enzyme glutamic acid decarboxylase (GAD), GAD65 and GAD67; the CB1 receptor that modulates GABA release; and the vesicular transporter VGAT that is responsible for loading GABA into synaptic vesicles (McIntire et al., 1997; Sagne et al., 1997).
Regulation (modulates) of Localization (release) of GABA in synaptic vesicles associated with gaba, cannabinoid receptor and generalized anxiety disorder
4) Confidence 0.08 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2893712 Disease Relevance 0.26 Pain Relevance 0.55
For example, the multiple increases and decreases found for CB1 may reflect the multiple roles that it has in synaptic development, plasticity, and regulating GABA release (Hajos and Freund, 2002).
Regulation (regulating) of Localization (release) of GABA associated with gaba and cannabinoid receptor
5) Confidence 0.08 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2893712 Disease Relevance 0.23 Pain Relevance 0.43
Cannabinoids, via CB1Rs, influence the release of glutamate, dopamine, acetylcholine, and GABA primarily presynaptically.
Regulation (influence) of Localization (release) of GABA associated with gaba, dopamine, glutamate and cannabinoid
6) Confidence 0.05 Published 2009 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2806533 Disease Relevance 0.32 Pain Relevance 0.75
CB1 is a pre-synaptic receptor involved in modulating GABA release (Hajos and Freund, 2002); over the lifespan there were significant changes in the expression of CB1 in human V1 (p <?
Regulation (modulating) of Localization (release) of GABA associated with gaba, cannabinoid receptor and lifespan
7) Confidence 0.05 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2893712 Disease Relevance 0.47 Pain Relevance 0.48

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