INT155992

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Context Info
Confidence 0.66
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 17.00
Pain Relevance 1.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (THBD) plasma membrane (THBD) embryo development (THBD)
Anatomy Link Frequency
endothelial cell 5
blood 1
muscle cells 1
monocytes 1
bladder 1
THBD (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 255 99.62 Very High Very High Very High
metalloproteinase 6 93.04 High High
cytokine 119 92.52 High High
imagery 6 88.28 High High
abdominal pain 2 87.36 High High
alcohol 8 84.60 Quite High
Inflammatory response 65 80.88 Quite High
corticosteroid 30 78.08 Quite High
rheumatoid arthritis 17 47.92 Quite Low
dexamethasone 6 42.72 Quite Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 199 99.64 Very High Very High Very High
INFLAMMATION 385 99.62 Very High Very High Very High
Cardiovascular Disease 194 99.54 Very High Very High Very High
Systemic Sclerosis 321 99.46 Very High Very High Very High
Bladder Cancer 7 99.04 Very High Very High Very High
Pancreatitis 84 98.86 Very High Very High Very High
Thrombosis 13 98.64 Very High Very High Very High
Carcinoma 42 97.92 Very High Very High Very High
Atherosclerosis 93 97.80 Very High Very High Very High
Brain Injury 144 97.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemical analysis confirmed the urothelial histotype (positive for thrombomodulin, p63 and high-molecular-weight cytokeratins) and disclosed focal neuroendocrine differentiation.
Gene_expression (positive) of thrombomodulin
1) Confidence 0.66 Published 2009 Journal Virchows Arch. Section Abstract Doc Link 19002493 Disease Relevance 0.80 Pain Relevance 0.13
Anti-U1RNP autoantibodies, anti-CL IgG/IgM type autoantibodies, AECA and both endothelial cell markers (TM and vWFAg) were significant increased in MCTD patients versus controls and in the MCTD/CVD+ versus MCTD/CVD- patient groups (Table 3).
Gene_expression (autoantibodies) of TM in endothelial cell associated with cardiovascular disease and systemic sclerosis
2) Confidence 0.48 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911856 Disease Relevance 2.91 Pain Relevance 0.08
Accordingly, in MCTD/CVD+ patients the soluble TM levels were significant higher than in the MCTD/CVD- group.
Gene_expression (levels) of TM associated with cardiovascular disease and systemic sclerosis
3) Confidence 0.48 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911856 Disease Relevance 2.10 Pain Relevance 0.10
Furthermore, we showed that the markers of endothelial cell dysfunction, vWFAg and soluble TM were higher in patients with MCTD than in the healthy individuals.
Gene_expression (higher) of TM in endothelial cell associated with systemic sclerosis
4) Confidence 0.43 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911856 Disease Relevance 2.06 Pain Relevance 0.11
release after TBI has been shown to have procoagulant effects, stimulating synthesis and release of sTF while suppressing cell-surface TM levels and the protein C pathway [35].
Gene_expression (levels) of TM associated with brain injury
5) Confidence 0.35 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819256 Disease Relevance 0.84 Pain Relevance 0.13
The study by Wang et al. also suggested that thrombomodulin expression as a marker of primary bladder carcinoma adds to the specificity of the CK7 and CK20 profile. 59% of primary bladder adenocarcinomas demonstrated significant expression of membranous thrombomodulin compared to 0% of colonic adenocarcinomas [15].
Gene_expression (expression) of thrombomodulin in bladder associated with adenocarcinoma and bladder cancer
6) Confidence 0.32 Published 2006 Journal BMC Urol Section Body Doc Link PMC1624844 Disease Relevance 1.23 Pain Relevance 0
is also a potent inducer of TF by ECs and monocytes [38,39], but inhibits cell-surface expression of TM [40], thus shifting the hemostatic balance towards intravascular thrombosis and hyperfibrinolysis with release of D-D fibrin degradation products [41].
Gene_expression (expression) of TM in monocytes associated with thrombosis
7) Confidence 0.32 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819256 Disease Relevance 1.26 Pain Relevance 0.23
These progenitors were uniformly positive for endothelial markers CD146, thrombomodulin, VEGFR2, VE-cadherin, CD31, CD34, and typically showed greater proliferative potential than circulating endothelial cells.
Gene_expression (positive) of thrombomodulin in endothelial cells
8) Confidence 0.21 Published 2010 Journal BMC Med Genomics Section Body Doc Link PMC2881111 Disease Relevance 0.26 Pain Relevance 0.09
Four of the up regulated genes, magic roundabout, hevin, thrombomodulin and sucrose non-fermenting protein-related kinase-1 are expressed specifically by endothelial cells and one, muscleblind-1, by muscle cells, suggesting that they may be associated with plexiform lesions and hypertrophic arterial wall remodelling, respectively.



Gene_expression (expressed) of thrombomodulin in muscle cells
9) Confidence 0.19 Published 2006 Journal Respir Res Section Abstract Doc Link PMC1351173 Disease Relevance 0.48 Pain Relevance 0.05
A variety of markers indicate endothelial dysfunction including: poor EC-dependent vasodilation, increased blood levels of von Willebrand factor (vWF), thrombomodulin, selectin, PAI-1, type IV collagen and t-PA were demonstrated in this patients population (Yaqoob et al 1993; Dosquet et al 1994; Myrup et al 1994; Makimattila et al 1996; Huszka et al 1997; Cosentino and Luscher 1998; Elhadd et al 1998; Malamitsi et al 1998; Huvers et al 1999).
Gene_expression (levels) of thrombomodulin in blood associated with increased venous pressure under development
10) Confidence 0.18 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350146 Disease Relevance 1.61 Pain Relevance 0
Previous animal models of SAP have suggested decreased inflammation, up-regulation of expressions of endothelial cell protein C receptor and thrombomodulin [28], and improved survival with APC in rats [7], although reports have been contradictory [29].
Gene_expression (expressions) of thrombomodulin in endothelial cell associated with inflammation and pancreatitis
11) Confidence 0.16 Published 2010 Journal Crit Care Section Body Doc Link PMC2945119 Disease Relevance 1.05 Pain Relevance 0.15
Moreover, pitavastatin is reported to have an inhibitory effect on plasminogen activator inihibitor-1 (PAI-1)22,23 and tissue factor (TF)23 which are important factors in thrombosis formation, and to induce tissue plasminogen activator (t-PA)23 and thrombomodulin (TM) expression.22,24 Therefore, pitavastatin is expected to exert its anti-atherosclerotic effect via various mechanisms.
Gene_expression (expression.22,24) of thrombomodulin associated with atherosclerosis and thrombosis
12) Confidence 0.14 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2788597 Disease Relevance 0.37 Pain Relevance 0.08
Age-modified plasma proteins can bind to AGE receptors (RAGE = AGE-receptor, macrophage scavenger receptor A) on different cell types like endothelial cells, where it can adversely affect the expression of thrombomodulin, tissue factor, and VCAM-1 genes.
Gene_expression (expression) of thrombomodulin in endothelial cells
13) Confidence 0.13 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2903979 Disease Relevance 0.59 Pain Relevance 0
Indeed, many exogenous bacterial products (such as endotoxin or CpG-DNA) (Refs 52, 71, 72) or endogenous proteins (such as human
       thrombomodulin, IgG1 or IL-1) (Refs 115, 150) may physically interact with HMGB1 to form
       various complexes. 
Gene_expression (products) of thrombomodulin
14) Confidence 0.09 Published 2008 Journal Expert Reviews in Molecular Medicine Section Body Doc Link PMC2586610 Disease Relevance 0.45 Pain Relevance 0.03
The anticoagulant effect of thrombin
         is regulated by thrombomodulin, a cofactor that is expressed on the luminal surface of
         vascular endothelium. 
Gene_expression (expressed) of thrombomodulin in vascular endothelium
15) Confidence 0.08 Published 2008 Journal Expert Reviews in Molecular Medicine Section Body Doc Link PMC2586610 Disease Relevance 0.60 Pain Relevance 0.08
MDCs express high levels of CD11c, BDCA1, and BDCA3 and myeloid related surface molecules, whereas PDCs lack the myeloid markers including CD11c, but they express the IL-3 receptor (CD123) [13].
Gene_expression (express) of BDCA3
16) Confidence 0.08 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2847547 Disease Relevance 0.39 Pain Relevance 0

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