INT156

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Context Info
Confidence 0.59
First Reported 1975
Last Reported 2010
Negated 15
Speculated 12
Reported most in Abstract
Documents 542
Total Number 554
Disease Relevance 131.97
Pain Relevance 192.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Prl)
Anatomy Link Frequency
plasma 88
pituitary 23
blood 7
body 5
lactotrophs 4
Prl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 687 100.00 Very High Very High Very High
narcan 682 100.00 Very High Very High Very High
Dopamine 529 100.00 Very High Very High Very High
Morphine 315 100.00 Very High Very High Very High
Opioid 238 100.00 Very High Very High Very High
opiate 207 100.00 Very High Very High Very High
anesthesia 126 100.00 Very High Very High Very High
Fibrositis 91 100.00 Very High Very High Very High
Pain 63 100.00 Very High Very High Very High
noradrenaline 54 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 632 100.00 Very High Very High Very High
Cancer 404 100.00 Very High Very High Very High
Galactorrhea 284 100.00 Very High Very High Very High
Disease 143 100.00 Very High Very High Very High
Reprotox - General 1 141 100.00 Very High Very High Very High
Celiac Disease 86 100.00 Very High Very High Very High
Pain 55 100.00 Very High Very High Very High
Convulsion 26 100.00 Very High Very High Very High
Eating Disorder 44 99.98 Very High Very High Very High
Decapitation 19 99.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This result suggested that an increase in dopamine secretion mediated the stress-induced decrease of PRL in the afternoon.
Negative_regulation (decrease) of PRL associated with stress and dopamine
1) Confidence 0.59 Published 1986 Journal Neuroendocrinology Section Abstract Doc Link 3724981 Disease Relevance 0.34 Pain Relevance 0.75
Plasma PRL levels were significantly reduced during both the diurnal and nocturnal surges on days 7-8 in multigravid rats when compared with levels in primigravid rats.
Negative_regulation (reduced) of PRL in Plasma
2) Confidence 0.59 Published 1993 Journal Life Sci. Section Abstract Doc Link 8336523 Disease Relevance 0 Pain Relevance 0.14
The administration of pimozide, a dopamine antagonist, increased plasma PRL and completely prevented the restraint-induced decrease in PRL.
Negative_regulation (decrease) of PRL in plasma associated with dopamine and antagonist
3) Confidence 0.59 Published 1986 Journal Neuroendocrinology Section Abstract Doc Link 3724981 Disease Relevance 0.34 Pain Relevance 0.66
Restraint stress applied at 16.00 h and continued for 3 h resulted in marked decrease in plasma prolactin (PRL) and an increase in plasma corticosterone (B).
Negative_regulation (decrease) of PRL in plasma associated with stress
4) Confidence 0.59 Published 1986 Journal Neuroendocrinology Section Abstract Doc Link 3724981 Disease Relevance 0.33 Pain Relevance 0.33
When rats were pretreated with 5,7-DHT several weeks before morphine challenge, serotonin depletion was more pronounced, but the PRL response to morphine was not decreased.
Neg (not) Negative_regulation (decreased) of PRL associated with serotonin and morphine
5) Confidence 0.59 Published 1987 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2435887 Disease Relevance 0 Pain Relevance 1.38
Suppression of the prolactin surges in the pseudopregnant rat by urethane anesthesia.
Negative_regulation (Suppression) of prolactin associated with anesthesia
6) Confidence 0.59 Published 1991 Journal Jikken Dobutsu Section Title Doc Link 2007438 Disease Relevance 0 Pain Relevance 0.35
These dopamine levels significantly but incompletely suppressed PRL levels, and a 36% decrease in administered dopamine was associated with only an approximate 1.5-fold increase in plasma PRL levels.
Negative_regulation (suppressed) of PRL in plasma associated with dopamine
7) Confidence 0.59 Published 1979 Journal Endocrinology Section Abstract Doc Link 487998 Disease Relevance 0 Pain Relevance 0.55
IDZ significantly lowered plasma PRL levels in OET rats; no elevated PRL values were observed in normal cycling rats, indicating that IDZ might inhibit PRL surges in these animals.
Spec (might) Negative_regulation (inhibit) of PRL in plasma
8) Confidence 0.59 Published 1991 Journal Horm. Metab. Res. Section Abstract Doc Link 2016076 Disease Relevance 0.23 Pain Relevance 0.12
The objective of this study was to determine if the effectiveness of dopamine as an inhibitor of prolactin is altered by estradiol in strains of rats which show marked differences in estrogen-induced pituitary hyperplasia.
Negative_regulation (inhibitor) of prolactin in pituitary associated with dopamine, pituitary cancer and sprains and strains
9) Confidence 0.59 Published 1992 Journal Life Sci. Section Abstract Doc Link 1731176 Disease Relevance 0.27 Pain Relevance 0.19
Morphine-induced prolactin release precedes a down-regulation of prolactin receptors in the male rat choroid plexus and hypothalamus.
Negative_regulation (down-regulation) of prolactin in choroid plexus associated with morphine
10) Confidence 0.59 Published 1995 Journal Neurosci. Res. Section Title Doc Link 8545080 Disease Relevance 0 Pain Relevance 0.39
Administration of the indirect DA agonist drug nomifensine (10 mg/kg iv) lowered plasma Prl levels in control rats, but failed to do so in rats bearing either macro- or microprolactinomas.
Neg (failed) Negative_regulation (lowered) of Prl in plasma associated with prolactinoma and agonist
11) Confidence 0.59 Published 1985 Journal Acta Endocrinol. Section Abstract Doc Link 4024849 Disease Relevance 0.48 Pain Relevance 0.21
We have recently demonstrated the existence of a neuromodulatory regulation of prolactin secretion by the opioid system showing a paradoxical opioid-induced prolactin suppression at the end of pregnancy.
Negative_regulation (suppression) of prolactin associated with opioid
12) Confidence 0.59 Published 1997 Journal J. Endocrinol. Section Abstract Doc Link 9390012 Disease Relevance 0 Pain Relevance 0.35
Naloxone administration did not decrease previously increased mean serum levels of prolactin in pituitary-grafted rats.
Neg (not) Negative_regulation (decrease) of prolactin in pituitary associated with narcan
13) Confidence 0.59 Published 1994 Journal Vet Hum Toxicol Section Abstract Doc Link 7900271 Disease Relevance 0.07 Pain Relevance 0.72
The lack of effect of naloxone-methobromide in pregnant rats pretreated with RU-486 may indicate that the opioid-induced prolactin suppression acts centrally, most probably at the hypothalamic level.
Negative_regulation (suppression) of prolactin associated with narcan and opioid
14) Confidence 0.59 Published 1994 Journal J. Endocrinol. Section Abstract Doc Link 8138757 Disease Relevance 0 Pain Relevance 0.37
On intraperitoneal administration (10 and 20 mg kg-1) it significantly decreased basal prolactin levels.
Negative_regulation (decreased) of prolactin
15) Confidence 0.59 Published 1988 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 2896781 Disease Relevance 0 Pain Relevance 0.18
In the unanesthetized normal male rat, 5 micrograms AVT first increased and then decreased levels of prolactin.
Negative_regulation (decreased) of prolactin
16) Confidence 0.59 Published 1980 Journal Horm. Res. Section Abstract Doc Link 6785180 Disease Relevance 0 Pain Relevance 0.22
Since AVT is capable of decreasing plasma prolactin levels, this peptide might be involved in the depression of plasma prolactin levels which appears to (at least partially) mediate pineal-induced gonadal degeneration.
Negative_regulation (decreasing) of prolactin in plasma associated with depression
17) Confidence 0.59 Published 1980 Journal Horm. Res. Section Abstract Doc Link 6785180 Disease Relevance 0.10 Pain Relevance 0.22
These changes are suggested to be responsible for the significant reduction in serum prolactin (PRL) response to a brief restraint stress in diabetic male rats, as compared with normoglycemic controls.
Negative_regulation (reduction) of prolactin associated with stress and diabetes mellitus
18) Confidence 0.59 Published 1994 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 8171046 Disease Relevance 0.61 Pain Relevance 0.40
In the same experiment clonidine, 0.2 mg/kg, suppressed basal prolactin levels to 4 +/- 1 ng/ml and returned prolactin levels of all animals receiving 0.2-5.0 mg/kg yohimbine to basal levels.
Negative_regulation (suppressed) of prolactin associated with clonidine
19) Confidence 0.59 Published 1986 Journal Neuroendocrinology Section Abstract Doc Link 3025757 Disease Relevance 0 Pain Relevance 0.47
Central injections of cimetidine, an H2 antihistaminic, reduced basal plasma prolactin levels from 5.08 +/- 0.76 to 3.11 +/- 0.50 ng/ml (N = 10) while diphenhydramine, an H1 antihistaminic, had no effect. 3.
Negative_regulation (reduced) of prolactin in plasma
20) Confidence 0.59 Published 1988 Journal Braz. J. Med. Biol. Res. Section Abstract Doc Link 3203168 Disease Relevance 0 Pain Relevance 0.42

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