INT156021

Context Info Confidence 0.57 First Reported 2005 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 8 Total Number 8 Disease Relevance 3.36 Pain Relevance 2.83

nucleoplasm (Creb1) mitochondrion (Creb1) nucleolus (Creb1) nucleus (Creb1) DNA binding (Creb1) transcription factor binding (Creb1)

Anatomy Link Frequency neuronal 2 spinal nerve 2 neurons 2 Creb1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Spinal nerve ligature 2 99.68 Calcitonin gene-related peptide 11 99.28 COX2 2 98.92 Neuronal excitability 2 93.56 Pain 15 92.08 Calcium channel 5 90.32 dorsal root ganglion 5 90.00 spinal dorsal horn 2 88.40 intrathecal 7 86.20 Dorsal horn neuron 3 85.68

Disease Link Frequency Relevance Heat Apoptosis 25 98.56 Nociception 18 94.04 Anxiety Disorder 4 94.04 Neuropathic Pain 5 92.20 Pain 10 92.08 Ganglion Cysts 6 90.00 Hypersensitivity 2 82.56 Hyperalgesia 1 77.80 INFLAMMATION 6 76.16 Inflammatory Pain 3 75.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Here, we provide direct evidence that a brief increase in CREB-dependent transcription in either CA1 or DG neurons, using in vivo viral vectors, is sufficient to boost memory for contextual representations, as tested in the contextual fear conditioning task, without affecting motor, pain, or anxiety behaviors.

Positive_regulation (increase) of Transcription (transcription) of CREB-dependent in neurons associated with pain and anxiety disorder

1) Confidence 0.57 Published 2009 Journal Hippocampus Section Abstract Doc Link 19004015 Disease Relevance 0.28 Pain Relevance 0.14

Acid elevated the transcriptional activity of CREB, which in turn stimulated CGRP gene promoter activity.

Positive_regulation (elevated) of Transcription (activity) of CREB associated with calcitonin gene-related peptide

2) Confidence 0.45 Published 2010 Journal Mol. Biol. Cell Section Abstract Doc Link 20534813 Disease Relevance 1.07 Pain Relevance 1.36

Moreover, spinal nerve ligation animals showed enhanced transcription of the CREB/CRE-dependent gene COX-2 (cyclooxygenase 2), which also depends strictly on Ca(V)1.2 activation.

Positive_regulation (enhanced) of Transcription (transcription) of CREB in spinal nerve associated with spinal nerve ligature and cox2

3) Confidence 0.43 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20089916 Disease Relevance 0.69 Pain Relevance 1.05

Phospho-CREB-induced gene transcription and strengthened synaptic transmission were widely reported in neuronal processing of various extracellular signals [8,13,14,17,20-22].

Positive_regulation (induced) of Transcription (transcription) of Phospho-CREB in neuronal

4) Confidence 0.43 Published 2005 Journal Mol Pain Section Body Doc Link PMC1224868 Disease Relevance 0 Pain Relevance 0.14

Synaptic activity-dependent phosphorylation of the transcription factor cAMP response element binding protein (CREB) leads to CREB-dependent gene transcription, a process thought to underlie long-term hippocampal synaptic plasticity and memory formation.

Positive_regulation (leads) of Transcription (transcription) of CREB-dependent

5) Confidence 0.38 Published 2009 Journal Hippocampus Section Abstract Doc Link 19004015 Disease Relevance 0 Pain Relevance 0.04

These include Gsk3, BAD, p21Cip1/WAF1, p27Kip1, and certain transcription factors and transcription factor regulators such as cAMP-response element binding protein (CREB), the FOXO family of Forkhead transcription factors, I?

Positive_regulation (include) of Transcription (transcription) of CREB

6) Confidence 0.11 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0.54 Pain Relevance 0.03

These include Gsk3, BAD, p21Cip1/WAF1, p27Kip1, and certain transcription factors and transcription factor regulators such as cAMP-response element binding protein (CREB), the FOXO family of Forkhead transcription factors, I?

Positive_regulation (include) of Transcription (transcription) of cAMP-response element binding protein

7) Confidence 0.11 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0.54 Pain Relevance 0.03

BDNF has been reported to activate transcription factors, such as CREB and NF?

Positive_regulation (as) of Transcription (transcription) of CREB

8) Confidence 0.11 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0.25 Pain Relevance 0.03

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