INT156021
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Here, we provide direct evidence that a brief increase in CREB-dependent transcription in either CA1 or DG neurons, using in vivo viral vectors, is sufficient to boost memory for contextual representations, as tested in the contextual fear conditioning task, without affecting motor, pain, or anxiety behaviors. | |||||||||||||||
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Acid elevated the transcriptional activity of CREB, which in turn stimulated CGRP gene promoter activity. | |||||||||||||||
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Moreover, spinal nerve ligation animals showed enhanced transcription of the CREB/CRE-dependent gene COX-2 (cyclooxygenase 2), which also depends strictly on Ca(V)1.2 activation. | |||||||||||||||
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Phospho-CREB-induced gene transcription and strengthened synaptic transmission were widely reported in neuronal processing of various extracellular signals [8,13,14,17,20-22]. | |||||||||||||||
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Synaptic activity-dependent phosphorylation of the transcription factor cAMP response element binding protein (CREB) leads to CREB-dependent gene transcription, a process thought to underlie long-term hippocampal synaptic plasticity and memory formation. | |||||||||||||||
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These include Gsk3, BAD, p21Cip1/WAF1, p27Kip1, and certain transcription factors and transcription factor regulators such as cAMP-response element binding protein (CREB), the FOXO family of Forkhead transcription factors, I? | |||||||||||||||
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These include Gsk3, BAD, p21Cip1/WAF1, p27Kip1, and certain transcription factors and transcription factor regulators such as cAMP-response element binding protein (CREB), the FOXO family of Forkhead transcription factors, I? | |||||||||||||||
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BDNF has been reported to activate transcription factors, such as CREB and NF? | |||||||||||||||
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General Comments
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