INT15604

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Context Info
Confidence 0.56
First Reported 1988
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 30
Total Number 32
Disease Relevance 9.70
Pain Relevance 2.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (FSHB) small molecule metabolic process (FSHB) extracellular region (FSHB)
cellular nitrogen compound metabolic process (FSHB) cytoplasm (FSHB)
Anatomy Link Frequency
Sertoli cell 4
pituitary gland 2
cartridge 1
spinal 1
gonadal 1
FSHB (Homo sapiens)
Pain Link Frequency Relevance Heat
potassium channel 3 99.48 Very High Very High Very High
opiate 3 98.12 Very High Very High Very High
antagonist 33 97.84 Very High Very High Very High
agonist 51 97.56 Very High Very High Very High
narcan 1 97.40 Very High Very High Very High
headache 12 96.48 Very High Very High Very High
sodium channel 4 95.36 Very High Very High Very High
Nicotine 4 93.96 High High
Opioid 4 92.00 High High
Codeine 2 89.08 High High
Disease Link Frequency Relevance Heat
Adenoma 241 99.96 Very High Very High Very High
Cancer 281 99.56 Very High Very High Very High
Nicotine Addiction 17 99.04 Very High Very High Very High
Disorder Of Lipid Metabolism 10 98.20 Very High Very High Very High
Brain Tumor 3 98.02 Very High Very High Very High
Hypopituitarism 13 97.64 Very High Very High Very High
Vomiting 4 97.00 Very High Very High Very High
Headache 12 96.48 Very High Very High Very High
Adrenal Cancer 92 95.72 Very High Very High Very High
Pituitary Cancer 105 91.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hormone testing revealed increased serum levels of FSH and decreased serum levels of LH.
Gene_expression (levels) of FSH
1) Confidence 0.56 Published 2003 Journal Ann. Endocrinol. (Paris) Section Abstract Doc Link 12910066 Disease Relevance 1.12 Pain Relevance 0.27
Patients who had used the prefilled follitropin alfa pen (1040 respondents) and follitropin beta pen (50 respondents) reported that they changed the pen/cartridge a mean value of 2.3 and 2.4 times per treatment cycle, respectively.
Gene_expression (used) of follitropin beta in cartridge
2) Confidence 0.39 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2949697 Disease Relevance 0 Pain Relevance 0
A greater proportion of patients in the group using the prefilled follitropin alfa pen found the pen very easy to handle, and quicker to learn to use and prepare for injection than those using the reusable follitropin beta pen.
Gene_expression (using) of follitropin beta
3) Confidence 0.39 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2949697 Disease Relevance 0 Pain Relevance 0.13
To assess that, we investigated the circulating levels of prolactin, TSH, LH, FSH and testosterone in male opium smokers who also smoke cigarettes (n=23, aged 28.4+/- 4.1 years), and comparing this with the corresponding values for nicotine abusers (n=12, 15-25 cigarettes/day) or a healthy control group (n=20) of the same age.
Spec (investigated) Gene_expression (levels) of FSH associated with nicotine addiction and nicotine
4) Confidence 0.36 Published 2005 Journal Addict Biol Section Abstract Doc Link 16318956 Disease Relevance 0.38 Pain Relevance 0.35
Impaired spermatogenesis has been observed in brain tumor survivors secondary to chemotherapy and in combination with spinal irradiation.[39] Inhibin B and FSH levels can assist in evaluating the gonadal damage.[39] Cases of panhypopituitarism secondary to treatment of brain tumors can be treated by gonadotropin replacement therapy, which could restore normal spermatogenesis.[40] Increased awareness of hemato-oncologists and other physicians treating male cancer patients to advances in reproductive techniques is of high priority.
Gene_expression (levels) of FSH in spinal associated with cancer, hypopituitarism and brain tumor
5) Confidence 0.29 Published 2010 Journal Journal of Human Reproductive Sciences Section Body Doc Link PMC2890901 Disease Relevance 0.60 Pain Relevance 0.19
Low FSH was detected in 43.48% of the opium smokers and 50% of the cigarette smokers (p<0.001) with normal LH and testosterone levels.
Gene_expression (detected) of FSH associated with nicotine addiction
6) Confidence 0.28 Published 2005 Journal Addict Biol Section Abstract Doc Link 16318956 Disease Relevance 0.60 Pain Relevance 0.33
At the initial visit, history and physical examination, with screening tests, including serum hormone levels (estradiol (E2), FSH, LH,), routine chemistries, lipid profiles (total cholesterol (TC), HDL-cholesterol (HDL-C), LDL-cholesterol (LDL-C), triglyceride (TG)), gynecologic sonography, mammography, EKG, and Pap smear were obtained.
Gene_expression (levels) of FSH associated with disorder of lipid metabolism
7) Confidence 0.19 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628120 Disease Relevance 1.02 Pain Relevance 0.03
FSH producing adenomas (FSHomas)
Gene_expression (producing) of FSH associated with adenoma
8) Confidence 0.16 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2522328 Disease Relevance 1.22 Pain Relevance 0.07
Immunohistochemically, the tumor cells are frequently positive for FSH?
Gene_expression (positive) of FSH associated with cancer
9) Confidence 0.14 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2522328 Disease Relevance 1.19 Pain Relevance 0.06
Neuroendocrine marker SNAP25 (b) and pituitary hormone FSH?
Gene_expression (marker) of FSH in pituitary
10) Confidence 0.14 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2522328 Disease Relevance 1.45 Pain Relevance 0
Grumbach [14] noted that because levels of FSH, LH, and sex steroid secretion are low in childhood and male infant levels of testosterone increase during the second week, reaching a maximum at 4 to 10 weeks and declining to low levels by the time the child is approximately 6 months old, in the scenario of micropenis with or without cryptorchidism, it is imperative to exploit the window of opportunity in order to establish the diagnosis hypogonadotropic hypogonadism.
Gene_expression (levels) of FSH associated with hypogonadotropic hypogonadism and cryptorchidism
11) Confidence 0.12 Published 2010 Journal International Journal of Pediatric Endocrinology Section Body Doc Link PMC2963131 Disease Relevance 0.68 Pain Relevance 0
The other trial, comparing follitropin beta and HP uFSH, also found a significantly lower requirement of FSH when using follitropin beta (Puregon) though there was no indication for a difference in duration of stimulation (mean 10.2 days versus 9.8 days).31 The total costs per cycle however were significantly higher for a follitropin beta cycle due to the lower costs per IU of HP uFSH.
Gene_expression (cycle) of follitropin beta
12) Confidence 0.12 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971716 Disease Relevance 0 Pain Relevance 0
The other trial, comparing follitropin beta and HP uFSH, also found a significantly lower requirement of FSH when using follitropin beta (Puregon) though there was no indication for a difference in duration of stimulation (mean 10.2 days versus 9.8 days).31 The total costs per cycle however were significantly higher for a follitropin beta cycle due to the lower costs per IU of HP uFSH.
Gene_expression (using) of follitropin beta
13) Confidence 0.12 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971716 Disease Relevance 0.11 Pain Relevance 0
This may reflect the need to differentially synthesize and secrete FSH and LH at different times during reproductive cycles to allow orderly follicular maturation and ovulation.
Gene_expression (synthesize) of FSH
14) Confidence 0.10 Published 1991 Journal Recent Prog. Horm. Res. Section Abstract Doc Link 1745819 Disease Relevance 0 Pain Relevance 0.17
Whilst estradiol production acts within the testis to retard early androgen production, it also acts in the pituitary gland to stimulate FSH production and thereby promote early Sertoli cell proliferation.
Gene_expression (production) of FSH in Sertoli cell
15) Confidence 0.09 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2254628 Disease Relevance 0 Pain Relevance 0
The importance of this estrogen-induced increase in FSH secretion is not known: it has not been established whether estradiol acting directly at the level of the testis is sufficient to produce qualitative spermatogenesis in hpg mice or whether the effects of estradiol in inducing spermatogenesis are more indirect, occurring via the rise in FSH production.
Gene_expression (production) of FSH in testis
16) Confidence 0.09 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2254628 Disease Relevance 0.07 Pain Relevance 0
Given that the estradiol treatment clearly elevated circulating FSH concentrations, this observation is consistent with the key role of FSH in Sertoli cell proliferation in mice [27], and with more recent studies where genetic induction of FSH production in hpg mice has increased Sertoli cell production [28].
Gene_expression (production) of FSH in Sertoli cell
17) Confidence 0.09 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2254628 Disease Relevance 0 Pain Relevance 0
Assay of serum samples using the human FSH kit confirmed that rhFSH was detectable in mice treated with rhFSH (Fig. 3D), and that the higher dose treatment (5 IU) produced a significantly higher circulating concentration of FSH (P < 0.01; Fig. 3D).
Gene_expression (produced) of FSH
18) Confidence 0.08 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2254628 Disease Relevance 0 Pain Relevance 0
Serum FSH concentrations were measured using both a commercially available human FSH ELISA kit (IDS Ltd UK) to determine the levels of recombinant hFSH circulating, and a rat FSH immunoradiometric kit (IDS Ltd UK) in order to estimate the total circulating FSH concentrations (i.e. endogenous and exogenous).
Gene_expression (kit) of FSH
19) Confidence 0.08 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2254628 Disease Relevance 0 Pain Relevance 0
Given that the estradiol treatment clearly elevated circulating FSH concentrations, this observation is consistent with the key role of FSH in Sertoli cell proliferation in mice [27], and with more recent studies where genetic induction of FSH production in hpg mice has increased Sertoli cell production [28].
Gene_expression (concentrations) of FSH in Sertoli cell
20) Confidence 0.08 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2254628 Disease Relevance 0 Pain Relevance 0

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