INT156064

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Context Info
Confidence 0.65
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 50
Total Number 53
Disease Relevance 13.38
Pain Relevance 2.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (LMNA) nuclear envelope (LMNA) structural molecule activity (LMNA)
nucleus (LMNA) cytoplasm (LMNA)
Anatomy Link Frequency
bands 4
germline 3
radius 2
spikes 1
muscles 1
LMNA (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 132 98.92 Very High Very High Very High
isoflurane 27 97.92 Very High Very High Very High
Pain 7 97.52 Very High Very High Very High
halothane 26 97.40 Very High Very High Very High
Pyramidal cell 40 97.32 Very High Very High Very High
long-term potentiation 7 97.32 Very High Very High Very High
Hippocampus 239 95.44 Very High Very High Very High
ketamine 303 90.24 High High
Thalamus 25 88.72 High High
cerebral cortex 33 88.60 High High
Disease Link Frequency Relevance Heat
Insulin Resistance 26 100.00 Very High Very High Very High
Aids-related Complex 105 99.98 Very High Very High Very High
Infection 32 99.76 Very High Very High Very High
Frailty 3 99.28 Very High Very High Very High
Disease 165 99.26 Very High Very High Very High
Muscular Dystrophy 70 99.16 Very High Very High Very High
Sprains And Strains 68 98.60 Very High Very High Very High
Dilated Cardiomyopathy 35 98.56 Very High Very High Very High
Stupor 20 98.48 Very High Very High Very High
Obesity 21 98.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In these experiments, the sorted subpopulations of human CD133+ cells derived from the blood of normal and DMD subjects were labeled according to their expression of human lamin A/C.
Gene_expression (expression) of lamin A/C in blood associated with muscular dystrophy
1) Confidence 0.65 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2377332 Disease Relevance 0.30 Pain Relevance 0.04
It might be possible that a different, more specific selection of LFP bands would allow to better capture such phenomena (e.g., could the LFP power suppression observed between 10 and 20?
Gene_expression (bands) of LFP in bands
2) Confidence 0.65 Published 2010 Journal Frontiers in Neuroenergetics Section Body Doc Link PMC2922938 Disease Relevance 0 Pain Relevance 0
The PPARG mutations in subjects without FPLD3 indicate the complexity of the relationship between mutations in this gene and clinical phenotypes, such as phenotype differences related to differences in functional impact, and the requirement for interactions with other genes before a phenotype is expressed.
Gene_expression (expressed) of FPLD3
3) Confidence 0.65 Published 2006 Journal BMC Med Genet Section Body Doc Link PMC1368963 Disease Relevance 0.40 Pain Relevance 0
Only two heterozygous germline PPARG mutations in FPLD3, namely P467L (present in two FPLD3 subjects) and V290M (present in one FPLD3 subject), were shown by convincing in vitro studies to act through a dominant negative mechanism [6,7].
Gene_expression (mutations) of FPLD3 in germline
4) Confidence 0.65 Published 2006 Journal BMC Med Genet Section Body Doc Link PMC1368963 Disease Relevance 0.14 Pain Relevance 0
The LFP is estimated to represent a region with a radius of 100–250??
Gene_expression (represent) of LFP in radius
5) Confidence 0.65 Published 2010 Journal Frontiers in Neural Circuits Section Body Doc Link PMC2876880 Disease Relevance 0 Pain Relevance 0.10
The LFP is estimated to represent a region with a radius of 100–250??
Gene_expression (estimated) of LFP in radius
6) Confidence 0.65 Published 2010 Journal Frontiers in Neural Circuits Section Body Doc Link PMC2876880 Disease Relevance 0 Pain Relevance 0.10
We chose to study the FPL muscle because it has weak monosynaptic Ia afferent connectivity and it is involved in fine motor control of the thumb.
Gene_expression (muscle) of FPL in thumb
7) Confidence 0.59 Published 2009 Journal J. Appl. Physiol. Section Abstract Doc Link 19008485 Disease Relevance 0 Pain Relevance 0.08
All subjects exhibited enhanced torque in biceps and FPL muscles after both types of high-frequency train.
Gene_expression (muscles) of FPL in muscles
8) Confidence 0.59 Published 2009 Journal J. Appl. Physiol. Section Abstract Doc Link 19008485 Disease Relevance 0 Pain Relevance 0.10
The expression levels of Caspase 3, caspase 4, caspase 10 and lamin A/C were increased in the infected animals compared to the controls.
Gene_expression (expression) of lamin A/C
9) Confidence 0.58 Published 2007 Journal Virol J Section Body Doc Link PMC2042503 Disease Relevance 0.85 Pain Relevance 0
The expression levels of Caspase 3, caspase 4, caspase 10 and lamin A/C were increased in the infected animals compared to the controls.
Gene_expression (levels) of lamin A/C
10) Confidence 0.58 Published 2007 Journal Virol J Section Body Doc Link PMC2042503 Disease Relevance 0.85 Pain Relevance 0
How might a quantitative relative loss-of-function mutation in one PPARG allele contribute to adipose repartitioning and insulin resistance in FPLD3?
Gene_expression (resistance) of FPLD3 associated with insulin resistance
11) Confidence 0.57 Published 2006 Journal BMC Med Genet Section Body Doc Link PMC1368963 Disease Relevance 0.52 Pain Relevance 0
Only two heterozygous germline PPARG mutations in FPLD3, namely P467L (present in two FPLD3 subjects) and V290M (present in one FPLD3 subject), were shown by convincing in vitro studies to act through a dominant negative mechanism [6,7].
Gene_expression (present) of FPLD3 in germline
12) Confidence 0.57 Published 2006 Journal BMC Med Genet Section Body Doc Link PMC1368963 Disease Relevance 0.19 Pain Relevance 0
AAATfs185, did not show dominant negative interference of the WT allele, and carriers of this mutation did not have FPLD3, but simple insulin resistance, which required double heterozygosity with a truncation mutation in PPP1R3A for clinical expression.
Gene_expression (resistance) of FPLD3 associated with insulin resistance
13) Confidence 0.57 Published 2006 Journal BMC Med Genet Section Body Doc Link PMC1368963 Disease Relevance 0.32 Pain Relevance 0
Only two heterozygous germline PPARG mutations in FPLD3, namely P467L (present in two FPLD3 subjects) and V290M (present in one FPLD3 subject), were shown by convincing in vitro studies to act through a dominant negative mechanism [6,7].
Gene_expression (present) of FPLD3 in germline
14) Confidence 0.57 Published 2006 Journal BMC Med Genet Section Body Doc Link PMC1368963 Disease Relevance 0.20 Pain Relevance 0
The reduction in power of the LFP was ?
Gene_expression (was) of LFP
15) Confidence 0.57 Published 2010 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2882822 Disease Relevance 0 Pain Relevance 0
As shown in Figures 8 and 9, synchronization between the LFP–MUA was equally absent for all plaid configurations.
Neg (absent) Gene_expression (synchronization) of LFP
16) Confidence 0.57 Published 2010 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2882822 Disease Relevance 0 Pain Relevance 0
SUA and LFP decoding
Gene_expression (decoding) of LFP
17) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3006173 Disease Relevance 0 Pain Relevance 0
However, despite the progress made to date on using LFP to extract information about response direction, the decoding power obtained using simultaneously recorded LFP, which is what would be required for effective BMI applications, has been relatively modest (?
Gene_expression (using) of LFP
18) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3006173 Disease Relevance 0 Pain Relevance 0
However, despite the progress made to date on using LFP to extract information about response direction, the decoding power obtained using simultaneously recorded LFP, which is what would be required for effective BMI applications, has been relatively modest (?
Gene_expression (using) of LFP
19) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3006173 Disease Relevance 0 Pain Relevance 0
This result may be accounted for in part by the fact that there were fewer SUA available than LFP channels.
Gene_expression (channels) of LFP
20) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3006173 Disease Relevance 0 Pain Relevance 0

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