INT15607

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Context Info
Confidence 0.62
First Reported 1983
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 7.56
Pain Relevance 2.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (GNRHR) signal transducer activity (GNRHR)
Anatomy Link Frequency
follicle 3
hypothalamus 2
pituitary 1
palate 1
GNRHR (Homo sapiens)
Pain Link Frequency Relevance Heat
Endogenous opioid 6 99.70 Very High Very High Very High
narcan 10 99.36 Very High Very High Very High
Neuropeptide 3 99.04 Very High Very High Very High
Opioid 12 98.32 Very High Very High Very High
opiate 10 95.56 Very High Very High Very High
agonist 10 94.92 High High
Fibrositis 77 92.56 High High
antagonist 10 90.08 High High
opioid receptor 2 90.00 High High
Morphine 3 59.68 Quite High
Disease Link Frequency Relevance Heat
Stress 24 99.46 Very High Very High Very High
Syndrome 10 99.02 Very High Very High Very High
Congenital Anomalies 19 98.36 Very High Very High Very High
Loss Of Sense Of Smell 1 97.20 Very High Very High Very High
Deafness 1 96.84 Very High Very High Very High
Anovulation 13 96.72 Very High Very High Very High
Cleft Palate 1 96.44 Very High Very High Very High
Adenoma 30 96.22 Very High Very High Very High
Reprotox - General 1 75 94.08 High High
Kallmann Syndrome 3 93.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Steroid hormones modulate the release of immunoreactive gonadotropin-releasing hormone from cultured human placental cells.
Localization (release) of gonadotropin-releasing hormone
1) Confidence 0.62 Published 1990 Journal J. Clin. Endocrinol. Metab. Section Title Doc Link 2156890 Disease Relevance 0 Pain Relevance 0.43
All patients underwent controlled ovarian hyperstimulation employing human menopausal gonadotropin and gonadotropin releasing hormone agonist, given either in the midluteal or early follicular phase.
Localization (releasing) of gonadotropin releasing hormone
2) Confidence 0.62 Published 1998 Journal J Reprod Med Section Body Doc Link 9749419 Disease Relevance 0 Pain Relevance 0
There is also evidence to implicate suprahypothalamic mechanism(s) that enhance endogenous opioid inhibition of secretion of gonadotropin-releasing hormone.
Localization (secretion) of gonadotropin-releasing hormone associated with endogenous opioid
3) Confidence 0.54 Published 1985 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 2990210 Disease Relevance 0 Pain Relevance 0.49
Substantial evidence now exists to indicate that the endogenous hypothalamic opioidergic mechanism(s) represents one of the important controlling systems for release of gonadotropin-releasing hormone.
Localization (release) of gonadotropin-releasing hormone
4) Confidence 0.54 Published 1985 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 2990210 Disease Relevance 0 Pain Relevance 0.35
Endogenous opioid regulation of gonadotropin-releasing hormone release from the human fetal hypothalamus in vitro.
Localization (release) of gonadotropin-releasing hormone in hypothalamus associated with endogenous opioid
5) Confidence 0.52 Published 1983 Journal J. Clin. Endocrinol. Metab. Section Title Doc Link 6311863 Disease Relevance 0 Pain Relevance 0.59
Gonadotropin-releasing hormone (GnRH) is the primary stimulator of gonadotropin secretion [1]–[5].
Localization (secretion) of Gonadotropin-releasing hormone
6) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2791420 Disease Relevance 0 Pain Relevance 0.05
There are three classes of anovulation, ie, WHO I, WHO II and WHO III.15–17 Women with WHO class I anovulation, which accounts for 10% of anovulatory women, have low or low–normal serum FSH concentrations and low serum estradiol concentrations due to decreased hypothalamic secretion of gonadotropin-releasing hormone (GnRH) or pituitary unresponsiveness to GnRH.
Localization (secretion) of gonadotropin-releasing hormone in pituitary associated with anovulation
7) Confidence 0.31 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971716 Disease Relevance 0.87 Pain Relevance 0
Its LD50i is >5000 mg/kg.14 When circulating, 47.5% is bound to sex hormone binding globulin (SHBG), 50% to albumin, while 2.5% is unbound.15 When bound to progesterone receptor in the hypothalamus, levonorgestrel is capable of slowing gonadotropin releasing hormone (GnRH) pulse release, quenching the pre-ovulatory luteinizing hormone (LH) surge.
Localization (release) of gonadotropin releasing hormone in hypothalamus
8) Confidence 0.26 Published 2009 Journal Patient Prefer Adherence Section Body Doc Link PMC2778424 Disease Relevance 0 Pain Relevance 0.04
The hypothalamus increases its secretion of gonadotropin releasing hormone (GnRH) which in turn stimulates the release of luteinizing hormone (LH) and follicle stimulating hormone (FSH).
Localization (secretion) of gonadotropin releasing hormone in follicle
9) Confidence 0.23 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2686330 Disease Relevance 0.58 Pain Relevance 0
Some of these pure somatotrope adenomas also express free alpha-subunit, which is common to the glycoprotein hormones follicle-stimulating hormone (FSH), luteinizing hormone (LH), thyroid-stimulating hormone (TSH) and chorionic gonadotropin hormone (CG, co-localized in the same cells or even in the same granules as GH) [36].
Localization (localized) of gonadotropin hormone in follicle associated with adenoma
10) Confidence 0.22 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2459162 Disease Relevance 1.79 Pain Relevance 0
The hypothalamus secretes gonadotropin-releasing hormone (GnRH) that acts on the anterior pituitary to produce follicle-stimulating hormone (FSH) and luteinizing hormone (LH).
Localization (secretes) of gonadotropin-releasing hormone in follicle
11) Confidence 0.21 Published 2010 Journal International Journal of Clinical Practice Section Body Doc Link PMC2948422 Disease Relevance 0.53 Pain Relevance 0
Stress has been shown to inhibit gonadotropin-releasing hormone and the pulsatile secretion of luteinizing hormone.
Localization (secretion) of gonadotropin-releasing hormone associated with stress
12) Confidence 0.19 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC416440 Disease Relevance 1.60 Pain Relevance 0.35
Gonadotropin-releasing hormone pulses: regulators of gonadotropin synthesis and ovulatory cycles.
Localization (releasing) of Gonadotropin-releasing hormone
13) Confidence 0.19 Published 1991 Journal Recent Prog. Horm. Res. Section Title Doc Link 1745819 Disease Relevance 0 Pain Relevance 0
In this syndrome, the defect is at the level of the hypothalamic secretion of gonadotropin-releasing hormone (GnRH) and may be associated with other congenital anomalies such as anosmia, deafness, cleft palate and renal anomalies.
Localization (secretion) of gonadotropin-releasing hormone in palate associated with deafness, cleft palate, congenital anomalies, syndrome and loss of sense of smell
14) Confidence 0.16 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721319 Disease Relevance 2.19 Pain Relevance 0

General Comments

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