INT156084

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Context Info
Confidence 0.02
First Reported 2009
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.31
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (PTGS2, AKR1C3) nucleus (PTGS2, AKR1C3) small molecule metabolic process (PTGS2)
endoplasmic reticulum (PTGS2) intracellular (AKR1C3) enzyme binding (PTGS2)
PTGS2 (Homo sapiens)
AKR1C3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 3 92.16 High High
Inflammation 1 75.00 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 2 79.88 Quite High
Reprotox - General 1 4 76.72 Quite High
Breast Cancer 1 48.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using known structure-activity relationships for the inhibition of PGHS-1 and PGHS-2 by indole acetic acids we obtained N-(4-chlorobenzoyl)-melatonin as a specific AKR1C3 inhibitor (K(I)=6.0muM) that does not inhibit PGHS-1, PGHS-2, AKR1C1, or AKR1C2.
PGHS-2 Neg (inhibit) Binding (inhibit) of AKR1C3
1) Confidence 0.02 Published 2009 Journal Chem. Biol. Interact. Section Abstract Doc Link 19010312 Disease Relevance 0.31 Pain Relevance 0.30

General Comments

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