INT156085

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Context Info
Confidence 0.54
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.79
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (AKR1C2) cytoplasm (AKR1C2)
AKR1C2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 6 93.68 High High
alcohol 1 83.52 Quite High
Inflammation 2 75.00 Quite High
palliative 1 51.68 Quite High
Opioid 1 48.12 Quite Low
antagonist 1 45.92 Quite Low
opioid receptor 1 45.48 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 4 88.08 High High
Reprotox - General 1 8 84.92 Quite High
Breast Cancer 2 56.84 Quite High
Constipation 2 52.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The AKR1C inhibitor phenolphthalein inhibited MNTX and naltrexone reduction up to 98%. 5beta-Cholanic acid 3alpha,7alpha-diol, the AKR1C2 inhibitor, and medroxyprogesterone acetate, an inhibitor of AKR1C1, AKR1C2, and AKR1C4, inhibited MNTX reduction up to 67%.
Negative_regulation (inhibitor) of AKR1C2
1) Confidence 0.54 Published 2010 Journal Drug Metab. Dispos. Section Abstract Doc Link 20173089 Disease Relevance 0.05 Pain Relevance 0.09
The second strategy exploits the selective inhibition of AKR1C3 by indomethacin, which did not inhibit highly related AKR1C1 or AKR1C2.
Negative_regulation (inhibit) of AKR1C2
2) Confidence 0.10 Published 2009 Journal Chem. Biol. Interact. Section Abstract Doc Link 19010312 Disease Relevance 0.43 Pain Relevance 0.27
Using known structure-activity relationships for the inhibition of PGHS-1 and PGHS-2 by indole acetic acids we obtained N-(4-chlorobenzoyl)-melatonin as a specific AKR1C3 inhibitor (K(I)=6.0muM) that does not inhibit PGHS-1, PGHS-2, AKR1C1, or AKR1C2.
Negative_regulation (inhibit) of AKR1C2
3) Confidence 0.08 Published 2009 Journal Chem. Biol. Interact. Section Abstract Doc Link 19010312 Disease Relevance 0.30 Pain Relevance 0.30

General Comments

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