INT15609

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Context Info
Confidence 0.49
First Reported 1984
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 17
Total Number 19
Disease Relevance 5.15
Pain Relevance 3.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (GNRH1) extracellular space (GNRH1) extracellular region (GNRH1)
cell-cell signaling (GNRH1)
Anatomy Link Frequency
pituitary 5
MBH 4
neurons 4
FSH 3
gonadal 2
GNRH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 38 100.00 Very High Very High Very High
narcan 24 100.00 Very High Very High Very High
antagonist 19 100.00 Very High Very High Very High
opiate 8 99.36 Very High Very High Very High
Endogenous opioid 6 97.92 Very High Very High Very High
medulla 2 96.04 Very High Very High Very High
Opioid 8 89.76 High High
headache 9 89.48 High High
corticosteroid 7 79.00 Quite High
Dismenorea 2 25.40 Quite Low
Disease Link Frequency Relevance Heat
Adenoma 4 100.00 Very High Very High Very High
Stroke 1 100.00 Very High Very High Very High
Pituitary Apoplexy 2 99.98 Very High Very High Very High
Endocrine Disease 3 99.48 Very High Very High Very High
Ovarian Cancer 3 96.80 Very High Very High Very High
Polycystic Ovary Syndrome 132 96.40 Very High Very High Very High
Turner's Syndrome 1 95.24 Very High Very High Very High
Anovulation 32 93.60 High High
Prostate Cancer 1 92.64 High High
Death 2 92.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
GnRH injected alone, during the naloxone infusion and with alpha-MSH produced similar increases in LH, that were significantly higher than that observed during the other tests (AUCs: GnRH 89.4 +/- 10.6, GnRH + naloxone 100.5 +/- 9.1, GnRH + alpha-MSH 94.6 +/- 7.9 mIU/ml.min-1, p < 0.001).
Positive_regulation (increases) of Gene_expression (produced) of GnRH associated with narcan
1) Confidence 0.49 Published 1997 Journal J. Endocrinol. Invest. Section Abstract Doc Link 9211127 Disease Relevance 0 Pain Relevance 0.82
Hypothalamic GnRH mRNA expression increased at 3.5 months of age and declined by 6 months of age.
Positive_regulation (increased) of Gene_expression (expression) of GnRH
2) Confidence 0.49 Published 2006 Journal Soc Reprod Fertil Suppl Section Abstract Doc Link 16866307 Disease Relevance 0.07 Pain Relevance 0.05
In males, the increased frequency and amplitude of GnRH secretion favor LH synthesis and release, which in turn stimulates testosterone secretion (Fig. 14).
Positive_regulation (increased) of Gene_expression (synthesis) of GnRH
3) Confidence 0.46 Published 1991 Journal Recent Prog. Horm. Res. Section Abstract Doc Link 1745819 Disease Relevance 0 Pain Relevance 0.19
Functional hypothalamic disorders are defined as the inability to liberate GnRH in a physiological way.
Positive_regulation (liberate) of Gene_expression (liberate) of GnRH
4) Confidence 0.37 Published 1988 Journal Hum. Reprod. Section Abstract Doc Link 3292572 Disease Relevance 0.66 Pain Relevance 0.10
They performed a subgroup analysis to compare HP HMG with rFSH and showed a similar outcomes in the HP-HMG group in terms of live birth rate (OR 1.21, 95% CI 1.02 to 1.44) and clinical pregnancy rate (OR 1.26, 95% CI 1.04 to 1.53).77 Two recent RCTs, one using a long downregulation protocol along with a GnRH agonist and the other a GnRH antagonist, failed to demonstrate any significant difference in pregnancy rates between HPFSH and rFSH.98,99
Positive_regulation (between) of Gene_expression (agonist) of GnRH associated with antagonist and agonist
5) Confidence 0.36 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2819896 Disease Relevance 0.06 Pain Relevance 0.10
They performed a subgroup analysis to compare HP HMG with rFSH and showed a similar outcomes in the HP-HMG group in terms of live birth rate (OR 1.21, 95% CI 1.02 to 1.44) and clinical pregnancy rate (OR 1.26, 95% CI 1.04 to 1.53).77 Two recent RCTs, one using a long downregulation protocol along with a GnRH agonist and the other a GnRH antagonist, failed to demonstrate any significant difference in pregnancy rates between HPFSH and rFSH.98,99
Positive_regulation (between) of Gene_expression (antagonist) of GnRH associated with antagonist and agonist
6) Confidence 0.36 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2819896 Disease Relevance 0.06 Pain Relevance 0.10
Meta-analyses of RCTs where GnRH antagonists (rather than GnRH agonist) were used for pituitary suppression also failed to find any significant differences in terms of clinical pregnancy rates, as none of the studies included reported live birth.79
Positive_regulation (rather) of Gene_expression (agonist) of GnRH in pituitary associated with antagonist and agonist
7) Confidence 0.36 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2819896 Disease Relevance 0.14 Pain Relevance 0.20
[Two cases of non-functional gonadotroph adenoma pituitary apoplexy following GnRH-agonist treatment revealing gonadotroph adenoma and pseudopituitary apoplexy after GnRH administration].
Positive_regulation (following) of in pituitary Gene_expression (administration) of GnRH in gonadotroph associated with adenoma, stroke, agonist and pituitary apoplexy
8) Confidence 0.36 Published 2003 Journal Ann. Endocrinol. (Paris) Section Title Doc Link 12910066 Disease Relevance 1.27 Pain Relevance 0.28
At a preprogrammed time in a child's life there is an increase in the amplitude of GnRH pulses which triggers a cascade of events including increases in the amplitude of FSH and LH pulses, followed by marked increases in gonadal sex steroidal output, which in turn increases growth hormone (GH) and insulin-like growth factor-1 (IGF-1) production.
Spec (like) Positive_regulation (increase) of Gene_expression (pulses) of GnRH in gonadal
9) Confidence 0.36 Published 1996 Journal Horm. Res. Section Abstract Doc Link 8742123 Disease Relevance 0 Pain Relevance 0.07
Such a GnRH stimulus would favour LH and androgen production and the failure of ovarian follicular maturation in PCO may reflect inappropriate sequential FSH secretion.
Positive_regulation (favour) of Gene_expression (stimulus) of GnRH in FSH associated with ovarian cancer
10) Confidence 0.30 Published 1993 Journal Hum. Reprod. Section Abstract Doc Link 8276970 Disease Relevance 0.55 Pain Relevance 0.18
In PCOS patients the increased LH/FSH ratio relates to a high GnRH excretion, but it is still uncertain if an intrinsic malfunction of the GnRH pulse generator or relatively low levels of progesterone, as a result of anovulatory menstrual cycles, are the underlying cause [Figure 2].[5] High GnRH expression could also be caused by low pituitary progesterone sensitivity, due to low circulating androgens.
Positive_regulation (caused) of Gene_expression (expression) of GnRH in pituitary associated with polycystic ovary syndrome
11) Confidence 0.29 Published 2010 Journal International Journal of Trichology Section Body Doc Link PMC3002408 Disease Relevance 0.62 Pain Relevance 0.04
High GnRH expression increases LH and low GnRH increases FSH synthesis.
Positive_regulation (increases) of Gene_expression (expression) of GnRH
12) Confidence 0.29 Published 2010 Journal International Journal of Trichology Section Body Doc Link PMC3002408 Disease Relevance 0.86 Pain Relevance 0.03
Again, this increase in Fos/FRA expression in GnRH neurons was limited to the MBH.
Positive_regulation (increase) of Gene_expression (expression) of GnRH in neurons
13) Confidence 0.28 Published 1999 Journal Endocrinology Section Abstract Doc Link 10579360 Disease Relevance 0.09 Pain Relevance 0.21
This treatment increased Fos/FRA expression in MBH GnRH neurons approximately 10-fold compared with control rams.
Positive_regulation (increased) of Gene_expression (expression) of GnRH in MBH
14) Confidence 0.28 Published 1999 Journal Endocrinology Section Abstract Doc Link 10579360 Disease Relevance 0.09 Pain Relevance 0.21
This indicates that the action of CC at least during the early follicular phase is exerted primarily at the levels of the hypothalamic GnRH pulse generator and does not depend on the activity of opiate neurons.
Positive_regulation (exerted) of Gene_expression (levels) of GnRH in neurons associated with opiate
15) Confidence 0.25 Published 1987 Journal Fertil. Steril. Section Abstract Doc Link 3106096 Disease Relevance 0 Pain Relevance 0.32
Exogenous GnRH administration can increase gonadotropin production and, potentially, spermatogenesis.
Positive_regulation (increase) of Gene_expression (production) of GnRH
16) Confidence 0.25 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721319 Disease Relevance 0.31 Pain Relevance 0
Opiates do not appear to be mediators of the suckling-induced suppression of GnRH or the release of prolactin in women.
Positive_regulation (suckling-induced) of Gene_expression (suppression) of GnRH associated with opiate
17) Confidence 0.23 Published 1993 Journal Endocrinol. Metab. Clin. North Am. Section Abstract Doc Link 8449188 Disease Relevance 0.29 Pain Relevance 0.10
These splicing variants may not be translated, a mechanism previously reported that restricts GnRH expression to the hypothalamus [59].
Positive_regulation (restricts) of Gene_expression (expression) of GnRH in hypothalamus
18) Confidence 0.17 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC293424 Disease Relevance 0.07 Pain Relevance 0.05
To investigate a proposed role for endogenous opioids in the inhibition of LH:RH-gonadotrophin release in the postpartum hypogonadotrophic state, LH and FSH responses to naloxone infusion (1.6 mg/h for 2 h) and to a pulse of LHRH (10 micrograms) were measured in five non breast-feeding women.
Positive_regulation (responses) of Gene_expression (pulse) of LHRH associated with narcan and endogenous opioid
19) Confidence 0.09 Published 1984 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 6430601 Disease Relevance 0 Pain Relevance 0.30

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