INT156093

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Context Info
Confidence 0.23
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 5.17
Pain Relevance 2.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ros1) cell proliferation (Ros1) plasma membrane (Ros1)
Anatomy Link Frequency
myocardium 2
hearts 2
Ros1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 8 99.84 Very High Very High Very High
Paracetamol 4 99.12 Very High Very High Very High
Inflammation 117 96.68 Very High Very High Very High
Morphine 2 94.64 High High
ischemia 73 91.48 High High
opioid receptor 1 90.56 High High
Enkephalin 1 85.72 High High
isoflurane 2 73.60 Quite High
cytokine 94 70.00 Quite High
COX-2 inhibitor 5 67.40 Quite High
Disease Link Frequency Relevance Heat
Stress 63 99.52 Very High Very High Very High
Apoptosis 114 99.02 Very High Very High Very High
INFLAMMATION 165 96.68 Very High Very High Very High
Death 24 95.96 Very High Very High Very High
Coronary Artery Disease 34 91.48 High High
Reperfusion Injury 47 90.40 High High
Aging 19 85.72 High High
Injury 38 84.32 Quite High
Cv Unclassified Under Development 48 82.96 Quite High
Toxicity 16 82.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This anti-apoptotic effect of ALA was observed to be closely associated with the inhibition of ROS generation, the increased activity of pERK 1/2 and the decreased activity of pJNK 1/2.
Negative_regulation (inhibition) of Positive_regulation (generation) of ROS associated with apoptosis
1) Confidence 0.23 Published 2009 Journal Korean Circulation Journal Section Body Doc Link PMC2771824 Disease Relevance 1.37 Pain Relevance 0.15
The anti-apoptotic effects of ALA were closely associated with the inhibition of ROS generation, increased activity of pERK 1/2 and decreased activity of pJNK 1/2.
Negative_regulation (inhibition) of Positive_regulation (generation) of ROS associated with apoptosis
2) Confidence 0.23 Published 2009 Journal Korean Circulation Journal Section Body Doc Link PMC2771824 Disease Relevance 0.96 Pain Relevance 0.06
Intracellular levels of reactive oxygen species (ROS), which were greatly increased after H/R, were significantly inhibited by capsaicin, pyrrolidine dithiocarbamate (PDTC) (50 micromol/L), and LY294002.
Negative_regulation (inhibited) of Positive_regulation (increased) of ROS associated with qutenza
3) Confidence 0.14 Published 2008 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 19011674 Disease Relevance 0.70 Pain Relevance 0.61
Compared to 6-month control animals, indices of oxidative (superoxide anion [O2( *-)] and 4-hydroxy-2-nonenal [4-HNE]) and nitrosative (protein nitrotyrosylation) stress were markedly increased in 33-month-old rat hearts. 33-month animals that had been treated with acetaminophen (30 mg/kg/day p.o. for 6 months) exhibited diminished age-related increases in cardiac ROS levels and TUNEL positive nuclei and these changes were accompanied by improvements in the Bax/Bcl2 ratio, diminished evidence of caspase-3 activation and increased phosphorylation of protein kinase B, ERK1/2, p70S6K and GSK-3beta.
Negative_regulation (diminished) of Positive_regulation (increases) of ROS in hearts associated with stress and paracetamol
4) Confidence 0.13 Published 2010 Journal Basic Res. Cardiol. Section Abstract Doc Link 20407780 Disease Relevance 0.42 Pain Relevance 0.33
The increase in ROS due to APC is impaired in the aged myocardium, even though the baseline ROS level is high in the aged myocardium [49].
Negative_regulation (impaired) of Positive_regulation (increase) of ROS in myocardium
5) Confidence 0.03 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2872846 Disease Relevance 0.16 Pain Relevance 0.39
There was attenuation of ROS accumulation in response to the Gb extract, reduction in the transcription of stress inducible catalase genes and glutathione S-transferase 4, demonstrating its ability to combat oxidative stress [91].
Negative_regulation (attenuation) of Positive_regulation (accumulation) of ROS associated with stress
6) Confidence 0.03 Published 2008 Journal The Open Dentistry Journal Section Body Doc Link PMC2581528 Disease Relevance 0.97 Pain Relevance 0.08
peptide, using a fluorescent dye-based assay (HE fluorescence) showed an increase in ROS generation, which was blocked by AICAR pre-treatment (Fig. 6A).
Negative_regulation (blocked) of Positive_regulation (increase) of ROS
7) Confidence 0.02 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1262754 Disease Relevance 0.29 Pain Relevance 0.21
This inhibition of ROS generation by AICAR treatment possibly blocks the down-stream targets thereby inhibiting the inflammatory gene expression.
Negative_regulation (inhibition) of Positive_regulation (generation) of ROS associated with inflammation
8) Confidence 0.02 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1262754 Disease Relevance 0.29 Pain Relevance 0.20

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