INT1561

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Context Info
Confidence 0.59
First Reported 1979
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 59
Total Number 59
Disease Relevance 18.12
Pain Relevance 20.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

ATPase activity (Dnahc8) cytoskeleton (Dnahc8) cilium (Dnahc8)
molecular_function (Dnahc8) biological_process (Dnahc8) cytoplasm (Dnahc8)
Anatomy Link Frequency
reticulum 6
neurons 3
vesicle 2
plasma 1
macrophages 1
Dnahc8 (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 58 100.00 Very High Very High Very High
Dopamine 40 100.00 Very High Very High Very High
Catecholamine 28 100.00 Very High Very High Very High
Morphine 105 99.98 Very High Very High Very High
halothane 4 99.98 Very High Very High Very High
narcan 28 99.76 Very High Very High Very High
sodium channel 20 99.46 Very High Very High Very High
Hyperalgesia 9 99.40 Very High Very High Very High
antagonist 25 99.36 Very High Very High Very High
tetrodotoxin 35 99.22 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 1410 99.92 Very High Very High Very High
Death 337 99.62 Very High Very High Very High
Ulcers 4 99.56 Very High Very High Very High
Hyperalgesia 9 99.40 Very High Very High Very High
Convulsion 22 98.58 Very High Very High Very High
Targeted Disruption 57 98.56 Very High Very High Very High
Neurodegenerative Disease 139 98.48 Very High Very High Very High
Necrosis 78 98.04 Very High Very High Very High
Epilepsy 29 97.90 Very High Very High Very High
Neuropathic Pain 20 97.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Halothane inhibits neural plasma membrane Ca(2+)-ATPase, a pump that ejects Ca2+ from the cell after influx through voltage- or ligand-activated channels.
Negative_regulation (inhibits) of ATPase in neural associated with halothane
1) Confidence 0.59 Published 1996 Journal Neurosci. Lett. Section Abstract Doc Link 8904791 Disease Relevance 0.13 Pain Relevance 0.40
Dehydroabietic acid-induced depolarisation and release of neurotransmitters are not influenced by tetrodotoxin and are associated with only marginal inhibition of membrane-associated ATPase activity.
Negative_regulation (inhibition) of ATPase associated with tetrodotoxin and neurotransmitter
2) Confidence 0.59 Published 1994 Journal Pharmacol. Toxicol. Section Abstract Doc Link 7870698 Disease Relevance 0 Pain Relevance 0.27
Acute morphine treatment produced the following: (1) increases in calmodulin levels in the young and old mice while having no effect on mature levels; (2) increases in activities of guanylate cyclase of mature mice while decreasing those of the old mice; (3) no effects on activity of adenylate cyclase; (4) decreased activity of cyclic AMP-phosphodiesterase in young mice only; (5) decreased activity of Ca2+, Mg2+-ATPase in the old mice only.
Neg (no) Negative_regulation (decreased) of ATPase associated with morphine
3) Confidence 0.57 Published 1985 Journal J. Neurochem. Section Abstract Doc Link 2857771 Disease Relevance 0.07 Pain Relevance 0.46
Contrary to short-term morphine treatment, long-term treatment significantly inhibited Na+,K+-ATPase activity.
Negative_regulation (inhibited) of ATPase associated with morphine
4) Confidence 0.56 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16317112 Disease Relevance 0.07 Pain Relevance 0.94
The study gives a firm support of the earlier finding that morphine inhibits ATPase.
Negative_regulation (inhibits) of ATPase associated with morphine
5) Confidence 0.52 Published 1985 Journal J Hirnforsch Section Abstract Doc Link 3005393 Disease Relevance 0 Pain Relevance 1.12
The catecholamine-sensitive ATPase activities were also inhibited by acute administration of morphine.
Negative_regulation (inhibited) of catecholamine-sensitive ATPase associated with catecholamine and morphine
6) Confidence 0.51 Published 1979 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 215749 Disease Relevance 0 Pain Relevance 1.28
Diabetic mice showed a significant increase in Na(+)-K(+)-ATPase activity at 3 weeks after streptozotocin treatment, whereas Na(+)-K(+)-ATPase activity was decreased at 12 weeks after treatment.
Negative_regulation (decreased) of ATPase associated with diabetes mellitus
7) Confidence 0.43 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18834878 Disease Relevance 1.07 Pain Relevance 0.49
It has been found that adouetine X (6) can decrease the activities of Ca(2+)-ATPase and Na(+)/K(+)-ATPase in vitro.
Negative_regulation (decrease) of ATPase
8) Confidence 0.43 Published 2009 Journal J. Nat. Prod. Section Abstract Doc Link 19231884 Disease Relevance 0.19 Pain Relevance 0.54
However, naloxone partially antagonized the morphine inhibition of depamine-sensitive ATPase activity but not norepinephrine-sensitive ATPase activity.
Negative_regulation (inhibition) of ATPase associated with narcan and morphine
9) Confidence 0.43 Published 1979 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 215749 Disease Relevance 0 Pain Relevance 1.37
However, naloxone partially antagonized the morphine inhibition of depamine-sensitive ATPase activity but not norepinephrine-sensitive ATPase activity.
Negative_regulation (inhibition) of ATPase associated with narcan and morphine
10) Confidence 0.43 Published 1979 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 215749 Disease Relevance 0 Pain Relevance 1.42
Morphine up to 10(-3) M had no effect on basal ATPase activities but at 10(-4) M significantly inhibited dopamine-sensitive ATPase activities in vitro.
Negative_regulation (inhibited) of ATPase associated with dopamine and morphine
11) Confidence 0.43 Published 1979 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 215749 Disease Relevance 0 Pain Relevance 1.17
It has been found that adouetine X (6) can decrease the activities of Ca(2+)-ATPase and Na(+)/K(+)-ATPase in vitro.
Negative_regulation (decrease) of ATPase
12) Confidence 0.43 Published 2009 Journal J. Nat. Prod. Section Abstract Doc Link 19231884 Disease Relevance 0.19 Pain Relevance 0.54
A significant decrease in the sensitivity of synaptosomal ATPase to catecholamines was observed in mice rendered tolerant by morphine pellet implantation.
Negative_regulation (decrease) of ATPase associated with catecholamine and morphine
13) Confidence 0.42 Published 1979 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 215749 Disease Relevance 0 Pain Relevance 1.41
We evaluated the modulation by Na+,K+-ATPase inhibitors of morphine-induced antinociception in the tail-flick test and [3H]naloxone binding to forebrain membranes.
Negative_regulation (inhibitors) of ATPase in forebrain associated with antinociception, narcan, tail-flick and morphine
14) Confidence 0.42 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12756273 Disease Relevance 0 Pain Relevance 0.82
However, substance P-induced tonic inward currents were blocked by thapsigargin, a Ca2+-ATPase inhibitor in the endoplasmic reticulum or by an external 1 mM Na+ solution.
Negative_regulation (inhibitor) of ATPase in reticulum associated with substance p
15) Confidence 0.41 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15219818 Disease Relevance 0 Pain Relevance 0.57
We have examined the effects of riluzole, a neuroprotective drug which stabilizes voltage-dependent sodium channels in their inactivated state and inhibits the release of glutamate in-vivo and in-vitro, on the release of newly taken up [3H]dopamine induced by ouabain, a potent and selective inhibitor of Na+/K+-ATPase in mouse striatal slices in-vitro.
Negative_regulation (inhibitor) of ATPase associated with dopamine, glutamate and sodium channel
16) Confidence 0.41 Published 1998 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 9877317 Disease Relevance 0 Pain Relevance 0.40
Moreover, an additional decrease in Na+,K+-ATPase activity was observed by naloxone precipitation.
Negative_regulation (decrease) of ATPase associated with narcan
17) Confidence 0.41 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16317112 Disease Relevance 0.06 Pain Relevance 1.00
The depolarization of neurons induced by impairment of Na+,K+-ATPase activity after long-term opiate treatment has been shown to involve the development of opioid dependence.
Negative_regulation (impairment) of ATPase in neurons associated with addiction, opiate and opioid
18) Confidence 0.41 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16317112 Disease Relevance 0.10 Pain Relevance 0.57
However, okadaic acid, a protein phosphatase inhibitor, suppressed short-term morphine stimulation but potentiated long-term morphine inhibition of Na+,K+-ATPase activity.
Negative_regulation (inhibition) of ATPase associated with morphine
19) Confidence 0.41 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16317112 Disease Relevance 0 Pain Relevance 0.95
Ouabain, an inhibitor of platelet Na(+)-K+ ATPase, blocked the stimulation by diamide in a concentration-dependent manner.
Negative_regulation (inhibitor) of ATPase in platelet
20) Confidence 0.37 Published 1992 Journal J. Biochem. Toxicol. Section Abstract Doc Link 1336056 Disease Relevance 0 Pain Relevance 0.15

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