INT156100

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Context Info
Confidence 0.65
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 9
Disease Relevance 3.64
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (AKR1B1) carbohydrate metabolic process (AKR1B1) response to stress (AKR1B1)
cytoplasm (AKR1B1) cytosol (AKR1B1) extracellular space (AKR1B1)
Anatomy Link Frequency
MCF-7 1
AKR1B1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 1 97.04 Very High Very High Very High
analgesia 1 96.68 Very High Very High Very High
antagonist 3 95.28 Very High Very High Very High
diclofenac 6 70.32 Quite High
Clonidine 2 50.00 Quite Low
Opioid 42 28.16 Quite Low
withdrawal 6 27.60 Quite Low
addiction 6 26.08 Quite Low
Analgesic 15 25.00 Low Low
headache 8 10.00 Low Low
Disease Link Frequency Relevance Heat
Breast Cancer 1 99.66 Very High Very High Very High
Adverse Drug Reaction 600 98.76 Very High Very High Very High
Renal Failure 18 83.56 Quite High
Death 30 80.08 Quite High
Meningitis 2 50.00 Quite Low
INFLAMMATION 2 50.00 Quite Low
Constipation 12 37.04 Quite Low
Hemorrhage 6 31.52 Quite Low
Vomiting 12 29.12 Quite Low
Opiate Addiction 12 28.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: Alpha(2)A-ADR, alpha(2)B-ADR, and alpha(2)C-ADR mRNA was expressed in RPE cells.
Gene_expression (expressed) of ADR
1) Confidence 0.65 Published 2009 Journal Graefes Arch. Clin. Exp. Ophthalmol. Section Body Doc Link 19011889 Disease Relevance 0 Pain Relevance 0
The observed cytostatic effect against the human breast cancer cell line MCF-7/ADR, highly expressing sigma(1) receptors, and not against MCF-7, as well as the enhancement of morphine analgesia highlighted the sigma(1) antagonist profile of this series of compounds.
Gene_expression (expressing) of ADR in MCF-7 associated with antagonist, breast cancer, analgesia and morphine
2) Confidence 0.58 Published 2010 Journal J. Med. Chem. Section Abstract Doc Link 20067271 Disease Relevance 0.10 Pain Relevance 0.31
Clinicians should be aware of this ADR and avoid prescribing NSAIDs for an extended period.


Gene_expression (aware) of ADR
3) Confidence 0.29 Published 2010 Journal Ann Pharmacother Section Body Doc Link 20197477 Disease Relevance 0 Pain Relevance 0
The median age was significantly higher in the ADR group at 72 years (Q1–Q3 56–81 years) compared with 61 years in the non-ADR group (Q1–Q3 41–77 years; U?
Gene_expression (group) of ADR
4) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2635959 Disease Relevance 0.46 Pain Relevance 0
The incidence of ADR episodes varied further according to the specialty of the wards studied as shown in Table 1.The median length of stay for patient episodes that resulted in an ADR was 20 days (Q1–Q3 12–35 days), compared to 8 days (Q1–Q3 5–13 days; U?
Gene_expression (episodes) of ADR
5) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2635959 Disease Relevance 0.53 Pain Relevance 0
Within the group of patients experiencing an ADR, the mortality was higher (n?
Gene_expression (experiencing) of ADR
6) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2635959 Disease Relevance 0.80 Pain Relevance 0.04
The incidence of ADR episodes varied further according to the specialty of the wards studied as shown in Table 1.The median length of stay for patient episodes that resulted in an ADR was 20 days (Q1–Q3 12–35 days), compared to 8 days (Q1–Q3 5–13 days; U?
Gene_expression (resulted) of ADR
7) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2635959 Disease Relevance 0.60 Pain Relevance 0.03
Similarly, of the 131 (62%) ADRs where the drug had been initiated prior to hospital admission, with the ADR occurring during admission, patients showed clinical signs in 81 (62%) cases.
Gene_expression (occurring) of ADR associated with adverse drug reaction
8) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2635959 Disease Relevance 0.82 Pain Relevance 0.03
The data were hierarchically structured, in that multiple ADR episodes can occur both within patients with multiple admissions to hospital and within a particular patient admission, hence the study collected data at the patient, admission, and ADR episode level.
Gene_expression (episodes) of ADR
9) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2635959 Disease Relevance 0.33 Pain Relevance 0

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