INT156131

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Context Info
Confidence 0.25
First Reported 2006
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 10.35
Pain Relevance 3.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Hand2) nucleus (Hand2) DNA binding (Hand2)
protein complex (Hand2) transcription factor binding (Hand2)
Anatomy Link Frequency
plasma 1
liver 1
lymphocyte 1
B cell 1
Th2 cells 1
Hand2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 288 99.96 Very High Very High Very High
Paracetamol 7 99.50 Very High Very High Very High
Inflammation 307 99.16 Very High Very High Very High
Neuritis 93 97.24 Very High Very High Very High
agonist 48 89.80 High High
Multiple sclerosis 42 87.04 High High
Glutamate 1 80.16 Quite High
antagonist 40 78.00 Quite High
Inflammatory response 29 67.84 Quite High
tolerance 6 66.24 Quite High
Disease Link Frequency Relevance Heat
Adhesions 13 100.00 Very High Very High Very High
Injury 29 99.92 Very High Very High Very High
Systemic Sclerosis 30 99.80 Very High Very High Very High
Asthma 463 99.78 Very High Very High Very High
Pneumonia 18 99.56 Very High Very High Very High
Gastritis 57 99.16 Very High Very High Very High
Encephalitis 12 98.36 Very High Very High Very High
Autoimmune Disease 39 98.20 Very High Very High Very High
Targeted Disruption 65 98.06 Very High Very High Very High
Optic Neuritis 68 97.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is therefore suggested that acetaminophen-induced liver injury is associated with Th1-dominant response in Th1/Th2 cytokine balance, and TNF-alpha may play a pathological role in the toxicity.
Th2 Binding (associated) of in liver associated with toxicity, paracetamol, injury and cytokine
1) Confidence 0.25 Published 2009 Journal Chem. Biol. Interact. Section Abstract Doc Link 19014921 Disease Relevance 1.14 Pain Relevance 0.73
, IL-2) and Th2 (IL-5 and IL-6) associated cytokines.
Th2 Binding (associated) of associated with cytokine
2) Confidence 0.20 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2270279 Disease Relevance 0.24 Pain Relevance 0.30
However, in one study the TZDs increased IL4 and IL10, and stimulated GATA3 expression (a transcription factor which shifts cells towards Th2 phenotype) [50]; although in other studies PPAR?
Th2 Binding (phenotype) of
3) Confidence 0.20 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC1781426 Disease Relevance 0.42 Pain Relevance 0.35
These results were confirmed by findings of human Th1/Th2 cytokines in plasma of G93A mice treated with different cell doses.
Th2 Binding (findings) of in plasma associated with cytokine
4) Confidence 0.19 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2429976 Disease Relevance 0.07 Pain Relevance 0.42
Lung sections were also stained with antibodies to the cell-adhesion molecule ICAM-1, the goblet cell marker Muc-5A, and the Th2 marker T1/ST2 (Santa Cruz BioTech, Santa Cruz, CA).


Th2 Binding (stained) of in Lung associated with adhesions
5) Confidence 0.18 Published 2006 Journal Virol J Section Body Doc Link PMC1488829 Disease Relevance 0.35 Pain Relevance 0.13
It is known that the balance between Th1 and Th2 cells is in part controlled by Vitamin A, which inhibits IL-12 synthesis through binding to retinoid receptors, thereby favouring a Th2 response [12].
Th2 Binding (binding) of in Th2 cells
6) Confidence 0.16 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2773769 Disease Relevance 0.30 Pain Relevance 0.07
Firstly, PPARs may inhibit Th2 trafficking into the intestinal mucosa by interfering with the endothelial adhesion molecules.
Th2 Binding (trafficking) of associated with adhesions
7) Confidence 0.15 Published 2010 Journal PPAR Research Section Body Doc Link PMC2796461 Disease Relevance 1.14 Pain Relevance 0.19
Numerous studies were subsequently performed to evaluate the exact role of TH1 cells in allergic asthma and their interplay with TH2 cells.
TH2 Binding (interplay) of associated with asthma
8) Confidence 0.15 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.52 Pain Relevance 0.10
Shifting the Th1/Th2 to the Th1 direction is one mechanism underlying increased susceptibility to EAN in apoE-deficient mice.
Th2 Binding (Shifting) of associated with neuritis
9) Confidence 0.12 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2825561 Disease Relevance 1.07 Pain Relevance 0.85
Through the action of the newly discovered Th17 mechanism, but not Th1 or Th2, the T cells, IgH-producing B cells, and antigen that causes CNS lesion interact to produce the pathophysiology of mouse encephalomyelitis and optic neuritis.
Th2 Binding (interact) of in T cells associated with optic neuritis, encephalitis and neuritis
10) Confidence 0.08 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2964037 Disease Relevance 1.48 Pain Relevance 0.55
Consistent with this, in transgenic mice with high serum levels of a soluble ST2-Ig recombinant protein, which would be expected to bind to and block the putative ligand, there is minimal reduction in Th2-dependent pulmonary inflammation [301,303].
Th2 Neg (block) Binding (bind) of associated with targeted disruption, inflammation and pneumonia
11) Confidence 0.07 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 1.08 Pain Relevance 0.15
While IgG1 antibodies are present in Th1 and Th2 immunity, B cell isotype switching to IgG2a requires IFN-?
Th2 Binding (immunity) of in B cell
12) Confidence 0.06 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1459156 Disease Relevance 0 Pain Relevance 0.03
Recently, the role of naturally occurring CD4+CD25+ Treg in Th1-, Th2-, and Th17-mediated gastritis has been described [71] and TGF?
Th2 Binding (occurring) of associated with gastritis
13) Confidence 0.05 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896618 Disease Relevance 1.37 Pain Relevance 0.07
SSc has been associated with T helper lymphocyte type-2 (TH-2) activation, cytokine production (particularly Il-4, IL-13, and IL-17), and excess collagen accumulation, which could participate in the development of vasculopathy [7].
TH-2 Binding (associated) of in lymphocyte associated with systemic sclerosis and cytokine
14) Confidence 0.00 Published 2010 Journal International Journal of Rheumatology Section Body Doc Link PMC2958499 Disease Relevance 1.17 Pain Relevance 0.05

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